Details for: Rest

Gene ID: 19712

Symbol: Rest

Ensembl ID: ENSMUSG00000029249

Description: RE1-silencing transcription factor

Associated with

  • Chromatin modifying enzymes
    (R-MMU-3247509)
  • Chromatin organization
    (R-MMU-4839726)
  • Hdacs deacetylate histones
    (R-MMU-3214815)
  • Auditory receptor cell stereocilium organization
    (GO:0060088)
  • Cardiac muscle cell myoblast differentiation
    (GO:0060379)
  • Cellular response to electrical stimulus
    (GO:0071257)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Cellular response to stress
    (GO:0033554)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin remodeling
    (GO:0006338)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Detection of mechanical stimulus involved in sensory perception of sound
    (GO:0050910)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Hematopoietic progenitor cell differentiation
    (GO:0002244)
  • Identical protein binding
    (GO:0042802)
  • Metal ion binding
    (GO:0046872)
  • Modification of synaptic structure
    (GO:0099563)
  • Negative regulation by host of viral transcription
    (GO:0043922)
  • Negative regulation of aldosterone biosynthetic process
    (GO:0032348)
  • Negative regulation of amniotic stem cell differentiation
    (GO:2000798)
  • Negative regulation of calcium ion-dependent exocytosis
    (GO:0045955)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cortisol biosynthetic process
    (GO:2000065)
  • Negative regulation of dense core granule biogenesis
    (GO:2000706)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of mesenchymal stem cell differentiation
    (GO:2000740)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of neurogenesis
    (GO:0050768)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription regulatory region dna binding
    (GO:2000678)
  • Nervous system process
    (GO:0050877)
  • Neuromuscular process controlling balance
    (GO:0050885)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of programmed cell death
    (GO:0043068)
  • Positive regulation of stem cell population maintenance
    (GO:1902459)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex
    (GO:0032991)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Regulation of alternative mrna splicing, via spliceosome
    (GO:0000381)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of osteoblast differentiation
    (GO:0045667)
  • Response to hypoxia
    (GO:0001666)
  • Response to ischemia
    (GO:0002931)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii core promoter sequence-specific dna binding
    (GO:0000979)
  • Sequence-specific dna binding
    (GO:0043565)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription repressor complex
    (GO:0017053)

Other Information

Genular Protein ID: 3163416140

Symbol: REST_MOUSE

Name: RE1-silencing transcription factor

UniProtKB Accession Codes:

Q8VIG1 A0JNY8 Q155C6 Q3U0W0 Q4VAD6 Q9CW43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 2 GO 62 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 7697725

Title: REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.

PubMed ID: 7697725

DOI: 10.1016/0092-8674(95)90298-8

PubMed ID: 7871435

Title: The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.

PubMed ID: 7871435

DOI: 10.1126/science.7871435

PubMed ID: 9771705

Title: NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis.

PubMed ID: 9771705

DOI: 10.1038/2431

PubMed ID: 10521596

Title: Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat.

PubMed ID: 10521596

DOI: 10.1016/s0169-328x(99)00196-5

PubMed ID: 10490617

Title: Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST.

PubMed ID: 10490617

DOI: 10.1128/mcb.19.10.6788

PubMed ID: 11039732

Title: Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element.

PubMed ID: 11039732

DOI: 10.1016/s0169-328x(00)00129-7

PubMed ID: 15907476

Title: REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

PubMed ID: 15907476

DOI: 10.1016/j.cell.2005.03.013

PubMed ID: 21284946

Title: Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes.

PubMed ID: 21284946

DOI: 10.1016/j.yjmcc.2011.01.017

PubMed ID: 21884984

Title: Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis.

PubMed ID: 21884984

DOI: 10.1016/j.molcel.2011.08.014

PubMed ID: 24670762

Title: REST and stress resistance in ageing and Alzheimer's disease.

PubMed ID: 24670762

DOI: 10.1038/nature13163

PubMed ID: 25727884

Title: RE1-silencing transcription factor (Rest) is a novel regulator of osteoblast differentiation.

PubMed ID: 25727884

DOI: 10.1002/jcb.25148

PubMed ID: 27819263

Title: REST regulation of gene networks in adult neural stem cells.

PubMed ID: 27819263

DOI: 10.1038/ncomms13360

PubMed ID: 29961578

Title: Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness.

PubMed ID: 29961578

DOI: 10.1016/j.cell.2018.06.004

Sequence Information:

  • Length: 1082
  • Mass: 117784
  • Checksum: 0D3616BC0820BC2F
  • Sequence:
    • MATQVMGQSS GGGSLFNNSA NMGMALTNDM YDLHELSKAE LAAPQLIMLA NVALTGEASG 
SCCDYLVGEE RQMAELMPVG DNHFSESEGE GLEESADLKG LENMELGSLE LSAVEPQPVF 
EASAAPEIYS ANKDPAPETP VAEDKCRSSK AKPFRCKPCQ YEAESEEQFV HHIRIHSAKK 
FFVEESAEKQ AKAWESGSSP AEEGEFSKGP IRCDRCGYNT NRYDHYMAHL KHHLRAGENE 
RIYKCIICTY TTVSEYHWRK HLRNHFPRKV YTCSKCNYFS DRKNNYVQHV RTHTGERPYK 
CELCPYSSSQ KTHLTRHMRT HSGEKPFKCD QCNYVASNQH EVTRHARQVH NGPKPLNCPH 
CDYKTADRSN FKKHVELHVN PRQFNCPVCD YAASKKCNLQ YHFKSKHPTC PSKTMDVSKV 
KLKKTKKREA DLLNNAVSNE KMENEQTKTK GDVSGKKNEK PVKAVGKDAS KEKKPGSSVS 
VVQVTTRTRK SAVAAETKAA EVKHTDGQTG NNPEKPCKAK KNKRKKDAEA HPSEEPVNEG 
PVTKKKKKSE CKSKIGTNVP KGGGRAEERP GVKKQSASLK KGTKKTPPKT KTSKKGGKLA 
PKGMGQTEPS SGALAQVGVS PDPALIQAEV TGSGSSQTEL PSPMDIAKSE PAQMEVSLTG 
PPPVEPAQME PSPAKPPQVE APTYPQPPQR GPAPPTGPAP PTGPAPPTEP APPTGLAEME 
PSPTEPSQKE PPPSMEPPCP EELPQAEPPP MEDCQKELPS PVEPAQIEVA QTAPTQVQEE 
PPPVSEPPRV KPTKRSSLRK DRAEKELSLL SEMARQEQVL MGVGLVPVRD SKLLKGNKSA 
QDPPAPPSPS PKGNSREETP KDQEMVSDGE GTIVFPLKKG GPEEAGESPA ELAALKESAR 
VSSSEQNSAM PEGGASHSKC QTGSSGLCDV DTEQKTDTVP MKDSAAEPVS PPTPTVDRDA 
GSPAVVASPP ITLAENESQE IDEDEGIHSH DGSDLSDNMS EGSDDSGLHG ARPTPPEATS 
KNGKAGLAGK VTEGEFVCIF CDRSFRKEKD YSKHLNRHLV NVYFLEEAAE EQEEQEEREE 
QE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.