Details for: Rfx2

Gene ID: 19725

Symbol: Rfx2

Ensembl ID: ENSMUSG00000024206

Description: regulatory factor X, 2 (influences HLA class II expression)

Associated with

  • Acrosome assembly
    (GO:0001675)
  • Cell differentiation
    (GO:0030154)
  • Cell projection organization
    (GO:0030030)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Cilium assembly
    (GO:0060271)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spermatid development
    (GO:0007286)
  • Spermatogenesis
    (GO:0007283)

Other Information

Genular Protein ID: 1386892711

Symbol: RFX2_MOUSE

Name: DNA-binding protein RFX2

UniProtKB Accession Codes:

P48379 Q8BXR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8289803

Title: RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

PubMed ID: 8289803

DOI: 10.1128/mcb.14.2.1230-1244.1994

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15229132

Title: RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis.

PubMed ID: 15229132

DOI: 10.1095/biolreprod.104.032268

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22233545

Title: RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.

PubMed ID: 22233545

DOI: 10.1016/j.ydbio.2011.12.030

PubMed ID: 26248850

Title: Rfx2 is required for spermatogenesis in the mouse.

PubMed ID: 26248850

DOI: 10.1002/dvg.22880

PubMed ID: 26162102

Title: RFX2 is a major transcriptional regulator of spermiogenesis.

PubMed ID: 26162102

DOI: 10.1371/journal.pgen.1005368

PubMed ID: 26853561

Title: Transcription factor RFX2 is a key regulator of mouse spermiogenesis.

PubMed ID: 26853561

DOI: 10.1038/srep20435

Sequence Information:

  • Length: 717
  • Mass: 79190
  • Checksum: 3A0EBF008ECD8B61
  • Sequence:
    • MQNSEGGADS PASVALRPAA QPMPASPQRV LVQAAGSTPK GTPMQTLTLP RVQPVPPQVQ 
HVYPAQVQYV EGGDAVYANG AIRAAYAYNP DPQLYAPSSA ASYFETPGGT QVTVAASSPP 
AVPSHGMVGI TMDVSGTPIV SGAGAYLIHG GMDGTRHSLA HTARSSPATL EMAIETLQKS 
EGLAPHKGGL LNSHLQWLLD NYETAEGVSL PRSSLYNHYL RHCQEHKLEP VNAASFGKLI 
RSVFMGLRTR RLGTRGNSKY HYYGIRLKPD SPLNRLQEDT QYMAMRQQPT HQKPRYRPAQ 
KSDSLGDGSA HSNMHGMPDQ AMATQGQHHQ QYIDVSHVFP EFPAPDLGST LLQESVTLHD 
VKALQLVYRR HCEATLDVVM NLQFQYIEKL WLSFWNCKAT SSDSCASLPA SDEDPEVTLL 
PKEKLISLCK CEPILQWMRS CDHILYQTLV ETLIPDVLRP VPSSLTQAIR NFAKSLEGWL 
INAMSGFPQQ VIQTKVGVVS AFAQTLRRYT SLNHLAQAAR AVLQNTSQIN QMLSDLNRVD 
FANVQEQASW VCQCEESLVQ RLEHDFKVTL QQQSSLDQWA SWLDNVVTQV LKQHSGSPSF 
PKAARQFLLK WSFYSSMVIR DLTLRSAASF GSFHLIRLLY DEYMFYLVEH RVAQATGETP 
IAVMGEFNDL ASLSLTLLDK EDIGDGHSSE ADVDGRSLGE PLVKRERSDP SHPLQGI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.