Details for: Rfx3

Gene ID: 19726

Symbol: Rfx3

Ensembl ID: ENSMUSG00000040929

Description: regulatory factor X, 3 (influences HLA class II expression)

Associated with

  • Cell differentiation
    (GO:0030154)
  • Cell maturation
    (GO:0048469)
  • Chromatin
    (GO:0000785)
  • Cilium-dependent cell motility
    (GO:0060285)
  • Cilium assembly
    (GO:0060271)
  • Determination of left/right symmetry
    (GO:0007368)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Endocrine pancreas development
    (GO:0031018)
  • Epithelial cilium movement involved in determination of left/right asymmetry
    (GO:0060287)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type b pancreatic cell development
    (GO:2000078)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of insulin secretion
    (GO:0050796)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription regulator complex
    (GO:0005667)
  • Type b pancreatic cell maturation
    (GO:0072560)

Other Information

Genular Protein ID: 3127711976

Symbol: RFX3_MOUSE

Name: Transcription factor RFX3

UniProtKB Accession Codes:

P48381 Q8BLW2 Q8C0R3 Q8VBY6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneTree 1 Genevisible 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8289803

Title: RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.

PubMed ID: 8289803

DOI: 10.1128/mcb.14.2.1230-1244.1994

PubMed ID: 15229132

Title: RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis.

PubMed ID: 15229132

DOI: 10.1095/biolreprod.104.032268

PubMed ID: 15121860

Title: The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification.

PubMed ID: 15121860

DOI: 10.1128/mcb.24.10.4417-4427.2004

PubMed ID: 16930429

Title: A deficiency in RFX3 causes hydrocephalus associated with abnormal differentiation of ependymal cells.

PubMed ID: 16930429

DOI: 10.1111/j.1460-9568.2006.05002.x

PubMed ID: 17229940

Title: Novel function of the ciliogenic transcription factor RFX3 in development of the endocrine pancreas.

PubMed ID: 17229940

DOI: 10.2337/db06-1187

PubMed ID: 19671664

Title: RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies.

PubMed ID: 19671664

DOI: 10.1242/jcs.048348

Sequence Information:

  • Length: 749
  • Mass: 83512
  • Checksum: 5527A5F3826D32AA
  • Sequence:
    • MQTSETGSDT GSTVTLQTSV ASQAAVPTQV VQQVPVQQQV QQVQTVQQVQ HVYPAQVQYV 
EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGSS AQVTTVVSSH SMVGTGGIQM 
GVTGGQLISS SGGTYLIGNS MENSGHSVTH TTRASPATIE MAIETLQKSD GLSTHRSSLL 
NSHLQWLLDN YETAEGVSLP RSTLYNHYLR HCQEHKLDPV NAASFGKLIR SIFMGLRTRR 
LGTRGNSKYH YYGIRVKPDS PLNRLQEDMQ YMAMRQQPMQ QKQRYKPMQK VDGVADGFTG 
SGQQTGTSVE QTVIAQSQHH QQFLDASRAL PEFGEVEISS LPDGTTFEDI KSLQSLYREH 
CEAILDVVVN LQFSLIEKLW QTFWRYSPST PADGTTITES SNLSEIESRL PKAKLITLCK 
HESILKWMCN CDHGMYQALV EILIPDVLRP IPSALTQAIR NFAKSLEGWL SNAMNNIPQR 
MIQTKVAAVS AFAQTLRRYT SLNHLAQAAR AVLQNTSQIN QMLSDLNRVD FANVQEQASW 
VCQCDDNMVQ RLETDFKMTL QQQSTLEQWA AWLDNVMMQA LKPYEGRPSF PKAARQFLLK 
WSFYSSMVIR DLTLRSAASF GSFHLIRLLY DEYMFYLVEH RVAQVTGETP IAVMGEFGDL 
NAVSPGNLDK DEGSEVESET DEDLDDSSEP RAKREKTELS QAFPVGCMQP VLESAVQPSL 
LNPLHSEHIV TSTQTIRQCS ATGNTYTAV

Genular Protein ID: 2197306273

Symbol: G5E890_MOUSE

Name: N/A

UniProtKB Accession Codes:

G5E890

Database IDs:

AGR 1 ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 5 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 SwissPalm 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 724
  • Mass: 80762
  • Checksum: 01ED4F1ABD730583
  • Sequence:
    • MQTSETGSDT GSTVTLQTSV ASQAAVPTQV VQQVPVQQQV QQVQTVQQVQ HVYPAQVQYV 
EGSDTVYTNG AIRTTTYPYT ETQMYSQNTG GNYFDTQGSS AQVTTVVSSH SMVGTGGIQM 
GVTGGQLISS SGGTYLIGNS MENSGHSVTH TTRASPATLQ WLLDNYETAE GVSLPRSTLY 
NHYLRHCQEH KLDPVNAASF GKLIRSIFMG LRTRRLGTRG NSKYHYYGIR VKPDSPLNRL 
QEDMQYMAMR QQPMQQKQRY KPMQKVDGVA DGFTGSGQQT GTSVEQTVIA QSQHHQQFLD 
ASRALPEFGE VEISSLPDGT TFEDIKSLQS LYREHCEAIL DVVVNLQFSL IEKLWQTFWR 
YSPSTPADGT TITESSNLSE IESRLPKAKL ITLCKHESIL KWMCNCDHGM YQALVEILIP 
DVLRPIPSAL TQAIRNFAKS LEGWLSNAMN NIPQRMIQTK VAAVSAFAQT LRRYTSLNHL 
AQAARAVLQN TSQINQMLSD LNRVDFANVQ EQASWVCQCD DNMVQRLETD FKMTLQQQST 
LEQWAAWLDN VMMQALKPYE GRPSFPKAAR QFLLKWSFYS SMVIRDLTLR SAASFGSFHL 
IRLLYDEYMF YLVEHRVAQV TGETPIAVMG EFGDLNAVSP GNLDKDEGSE VESETDEDLD 
DSSEPRAKRE KTELSQAFPV GCMQPVLESA VQPSLLNPLH SEHIVTSTQT IRQCSATGNT 
YTAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.