Details for: Rgn

Gene ID: 19733

Symbol: Rgn

Ensembl ID: ENSMUSG00000023070

Description: regucalcin

Associated with

  • Calcium ion binding
    (GO:0005509)
  • Cytoplasm
    (GO:0005737)
  • Enzyme regulator activity
    (GO:0030234)
  • Gluconolactonase activity
    (GO:0004341)
  • Hydrolase activity
    (GO:0016787)
  • Intracellular calcium ion homeostasis
    (GO:0006874)
  • L-ascorbic acid biosynthetic process
    (GO:0019853)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bone development
    (GO:1903011)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of dna catabolic process
    (GO:1903625)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of flagellated sperm motility
    (GO:1901318)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of rna biosynthetic process
    (GO:1902679)
  • Nucleus
    (GO:0005634)
  • Positive regulation of fatty acid biosynthetic process
    (GO:0045723)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of proteolysis involved in protein catabolic process
    (GO:1903052)
  • Positive regulation of triglyceride biosynthetic process
    (GO:0010867)
  • Regulation of calcium-mediated signaling
    (GO:0050848)
  • Spermatogenesis
    (GO:0007283)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 468396150

Symbol: RGN_MOUSE

Name: Regucalcin

UniProtKB Accession Codes:

Q64374 A2AFC8 Q3UJG3 Q60944

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CPTAC 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 2 EMBL 6 EPD 1 Ensembl 1 GO 26 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8765750

Title: Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30).

PubMed ID: 8765750

DOI: 10.1016/0167-4781(96)00064-4

PubMed ID: 9278263

Title: Molecular cloning of the cDNA coding for regucalcin and its mRNA expression in mouse liver: the expression is stimulated by calcium administration.

PubMed ID: 9278263

DOI: 10.1023/a:1006887929369

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14975739

Title: SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.

PubMed ID: 14975739

DOI: 10.1016/j.bbrc.2004.01.091

PubMed ID: 16585534

Title: Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy.

PubMed ID: 16585534

DOI: 10.1073/pnas.0511225103

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23349732

Title: Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase.

PubMed ID: 23349732

DOI: 10.1371/journal.pone.0053706

Sequence Information:

  • Length: 299
  • Mass: 33407
  • Checksum: DAD55EF618311977
  • Sequence:
    • MSSIKVECVL RENYRCGESP VWEEASQSLL FVDIPSKIIC RWDTVSNQVQ RVAVDAPVSS 
VALRQLGGYV ATIGTKFCAL NWENQSVFVL AMVDEDKKNN RFNDGKVDPA GRYFAGTMAE 
ETAPAVLERH QGSLYSLFPD HSVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYTVDAFDY 
DLQTGQISNR RIVYKMEKDE QIPDGMCIDA EGKLWVACYN GGRVIRLDPE TGKRLQTVKL 
PVDKTTSCCF GGKDYSEMYV TCARDGLNAE GLLRQPDAGN IFKITGLGVK GIAPYSYAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.