Genular: Defining Cellular Identity and Function

Details for: Rheb

Gene ID: 19744

Symbol: Rheb

Ensembl ID: ENSMUSG00000028945

Description: Ras homolog enriched in brain

Associated with

Amino acids regulate mtorc1
(R-MMU-9639288)
Autophagy
(R-MMU-9612973)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to starvation
(R-MMU-9711097)
Energy dependent regulation of mtor by lkb1-ampk
(R-MMU-380972)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intracellular signaling by second messengers
(R-MMU-9006925)
Macroautophagy
(R-MMU-1632852)
Mtorc1-mediated signalling
(R-MMU-166208)
Mtor signalling
(R-MMU-165159)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten gene transcription
(R-MMU-8943724)
Rna polymerase ii transcription
(R-MMU-73857)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Cellular response to nutrient levels
(GO:0031669)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endomembrane system
(GO:0012505)
Endoplasmic reticulum
(GO:0005783)
Gdp binding
(GO:0019003)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Neuronal cell body
(GO:0043025)
Nucleotide binding
(GO:0000166)
Oligodendrocyte differentiation
(GO:0048709)
Plasma membrane
(GO:0005886)
Positive regulation of oligodendrocyte differentiation
(GO:0048714)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of tor signaling
(GO:0032008)
Postsynaptic density
(GO:0014069)
Protein kinase activator activity
(GO:0030295)
Protein kinase binding
(GO:0019901)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of postsynapse organization
(GO:0099175)
Regulation of tor signaling
(GO:0032006)
Regulation of type b pancreatic cell development
(GO:2000074)
Signal transduction
(GO:0007165)
Small gtpase-mediated signal transduction
(GO:0007264)
Spliceosomal complex
(GO:0005681)
Synapse
(GO:0045202)

Other Information

Proteins

GTP-binding protein Rheb

Genular Protein ID: 3479023666

Symbol: RHEB_MOUSE

Name: GTP-binding protein Rheb

UniProtKB Accession Codes:

Q921J2

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12820960

Title: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

PubMed ID: 12820960

DOI: 10.1016/s1097-2765(03)00220-x

PubMed ID: 16631613

Title: Localization of Rheb to the endomembrane is critical for its signaling function.

PubMed ID: 16631613

DOI: 10.1016/j.bbrc.2006.03.220

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21321084

Title: Rheb is essential for murine development.

PubMed ID: 21321084

DOI: 10.1128/mcb.00985-10

PubMed ID: 21336308

Title: Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.

PubMed ID: 21336308

DOI: 10.1038/ncb2168

PubMed ID: 24648513

Title: Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).

PubMed ID: 24648513

DOI: 10.1074/jbc.c113.543736

Sequence Information:

Length: 184
Mass: 20451
Checksum: 7EC58080BDF92DFB
Sequence:

MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD 
TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK 
KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF KRIILEAEKI DGAASQGKSS 
CSVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rheb

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. PubMed ID: 12820960

Localization of Rheb to the endomembrane is critical for its signaling function. PubMed ID: 16631613

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Rheb is essential for murine development. PubMed ID: 21321084

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. PubMed ID: 21336308

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). PubMed ID: 24648513