Genular: Defining Cellular Identity and Function

Details for: Rock1

Gene ID: 19877

Symbol: Rock1

Ensembl ID: ENSMUSG00000024290

Description: Rho-associated coiled-coil containing protein kinase 1

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Eph-ephrin signaling
(R-MMU-2682334)
Ephb-mediated forward signaling
(R-MMU-3928662)
G alpha (12/13) signalling events
(R-MMU-416482)
Gpcr downstream signalling
(R-MMU-388396)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Programmed cell death
(R-MMU-5357801)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rhobtb1 gtpase cycle
(R-MMU-9013422)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rhoc gtpase cycle
(R-MMU-9013106)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate rocks
(R-MMU-5627117)
Rhoh gtpase cycle
(R-MMU-9013407)
Rnd3 gtpase cycle
(R-MMU-9696264)
Sema4d induced cell migration and growth-cone collapse
(R-MMU-416572)
Sema4d in semaphorin signaling
(R-MMU-400685)
Semaphorin interactions
(R-MMU-373755)
Signaling by gpcr
(R-MMU-372790)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Actin cytoskeleton organization
(GO:0030036)
Actomyosin structure organization
(GO:0031032)
Apical constriction
(GO:0003383)
Apoptotic process
(GO:0006915)
Aspartic-type endopeptidase inhibitor activity
(GO:0019828)
Atp binding
(GO:0005524)
Bleb assembly
(GO:0032060)
Blood vessel diameter maintenance
(GO:0097746)
Canonical nf-kappab signal transduction
(GO:0007249)
Cortical actin cytoskeleton organization
(GO:0030866)
Cytoskeleton organization
(GO:0007010)
Embryonic morphogenesis
(GO:0048598)
Epithelial to mesenchymal transition
(GO:0001837)
Kinase activity
(GO:0016301)
Leukocyte cell-cell adhesion
(GO:0007159)
Leukocyte migration
(GO:0050900)
Leukocyte tethering or rolling
(GO:0050901)
Membrane to membrane docking
(GO:0022614)
Metal ion binding
(GO:0046872)
Mitotic cytokinesis
(GO:0000281)
Motor neuron apoptotic process
(GO:0097049)
Mrna destabilization
(GO:0061157)
Myoblast migration
(GO:0051451)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of myosin-light-chain-phosphatase activity
(GO:0035509)
Negative regulation of phosphorylation
(GO:0042326)
Negative regulation of protein binding
(GO:0032091)
Neuron projection arborization
(GO:0140058)
Neuron projection development
(GO:0031175)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Podocyte cell migration
(GO:0090521)
Positive regulation of amyloid-beta clearance
(GO:1900223)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of dephosphorylation
(GO:0035306)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of phosphatase activity
(GO:0010922)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to plasma membrane
(GO:0072659)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of actin filament-based process
(GO:0032970)
Regulation of angiotensin-activated signaling pathway
(GO:0110061)
Regulation of cell migration
(GO:0030334)
Regulation of keratinocyte differentiation
(GO:0045616)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of neuron differentiation
(GO:0045664)
Regulation of synapse maturation
(GO:0090128)
Regulation of synaptic vesicle endocytosis
(GO:1900242)
Response to transforming growth factor beta
(GO:0071559)
Rho-dependent protein serine/threonine kinase activity
(GO:0072518)
Rho protein signal transduction
(GO:0007266)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Transferase activity
(GO:0016740)

Other Information

Proteins

Rho-associated protein kinase 1
Q3UE22_MOUSE

Genular Protein ID: 929813496

Symbol: ROCK1_MOUSE

Name: Rho-associated protein kinase 1

UniProtKB Accession Codes:

P70335 Q8C3G4 Q8C7H0

Database IDs:

Citations:

PubMed ID: 8772201

Title: ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.

PubMed ID: 8772201

DOI: 10.1016/0014-5793(96)00811-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15753128

Title: ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles.

PubMed ID: 15753128

DOI: 10.1083/jcb.200411179

PubMed ID: 16741948

Title: Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane.

PubMed ID: 16741948

DOI: 10.1002/jcp.20699

PubMed ID: 17654484

Title: Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions.

PubMed ID: 17654484

DOI: 10.1002/jcp.21215

PubMed ID: 19036714

Title: Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.

PubMed ID: 19036714

DOI: 10.1126/scisignal.1161938

PubMed ID: 19181962

Title: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.

PubMed ID: 19181962

DOI: 10.1152/ajpheart.01038.2008

PubMed ID: 20008297

Title: ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.

PubMed ID: 20008297

DOI: 10.1182/blood-2009-08-237222

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21768292

Title: Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.

PubMed ID: 21768292

DOI: 10.1083/jcb.201007108

PubMed ID: 22493320

Title: Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.

PubMed ID: 22493320

DOI: 10.1091/mbc.e11-11-0937

PubMed ID: 30115939

Title: Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1).

PubMed ID: 30115939

DOI: 10.1038/s41598-018-30115-3

Sequence Information:

Length: 1354
Mass: 158171
Checksum: A1CBD543B831CF96
Sequence:

MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK 
DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 
FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 
EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 
ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 
DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 
SDIDTSNFDD LEEDKGDEET FPIPKAFVGN QLPFVGFTYY SNRRYLPSAN ASENRSSSNV 
DKSLQESLQK TIYKLEEQLH NEMQLKDEME QKCRTSNLKL DKIMKELDEE GNQRRNLESA 
VSQIEKEKML LQHRINEYQR KVEQENEKRR NIENEVSTLK DQLEDLRKAS QTSQLANEKL 
TQLQKQLEEA NDLLRTESDT AVRLRKSHTE MSKSISQLES LNRELQERNR ILENSKSQAD 
KDYYQLQAVL EAERRDRGHD SEMIGDLQAR ITSLQEEVKH LKHNLERVEG ERKEAQDMLN 
HSEKEKNNLE IDLNYKLKSI QQRLEQEVNE HKVTKARLTD KHQSIEEAKS VAMCEMEKKL 
KEEREAREKA ENRVVETEKQ CSMLDVDLKQ SQQKLEHLTE NKERMEDEVK NLALQLEQES 
NKRLLLQNEL KTQAFEADNL KGLEKQMKQE INTLLEAKRL LEFELAQLTK QYRGNEGQMR 
ELQDQLEAEQ YFSTLYKTQV KELKEEIEEK NRENLRKIQE LQSEKETLST QLDLAETKAE 
SEQLARGILE EQYFELTQES KKAASRNRQE ITDKDHTVSR LEETNSVLTK DIEMLRKENE 
ELNERMRTAE EEYKLKKEEE INNLKAAFEK NISTERTLKT QAVNKLAEIM NRKDFKIDRK 
KANTQDLRKK EKENRKLQLE LNQEREKFNQ MVVKHQKELN DMQAQLVEEC THRNELQMQL 
ASKESDIEQL RAKLLDLSDS TSVASFPSAD ETDGNLPESR IEGWLSVPNR GNIKRYGWKK 
QYVVVSSKKI LFYNDEQDKE QSSPSMVLDI DKLFHVRPVT QGDVYRAETE EIPKIFQILY 
ANEGECRKDI EVEPVQQGEK TNFQNHKGHE FIPTLYHFPA NCEACAKPLW HVFKPPPALE 
CRRCHVKCHR DHLDKKEDLI SPCKVSYDVT SARDMLLLAC SQDEQKKWVT HLVKKIPKNP 
PSGFVRASPR TLSTRSTANQ SFRKVVKNTS GKTS

Genular Protein ID: 1526176369

Symbol: Q3UE22_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UE22

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 259
Mass: 29769
Checksum: 326ABF3F1CCAF9A0
Sequence:

MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF FWEERDIMAF 
ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA EVVLALDAIH 
SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY ISPEVLKFQG 
GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP DDNDISKEAK 
NLICAFLTDR EVRLGRNGV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rock1

Associated with

Other Information

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. PubMed ID: 8772201

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. PubMed ID: 15753128

Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. PubMed ID: 16741948

Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions. PubMed ID: 17654484

Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. PubMed ID: 19036714

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. PubMed ID: 19181962

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. PubMed ID: 20008297

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. PubMed ID: 21768292

Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction. PubMed ID: 22493320

Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). PubMed ID: 30115939

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073