Genular: Defining Cellular Identity and Function

Details for: Rock2

Gene ID: 19878

Symbol: Rock2

Ensembl ID: ENSMUSG00000020580

Description: Rho-associated coiled-coil containing protein kinase 2

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Eph-ephrin signaling
(R-MMU-2682334)
Ephb-mediated forward signaling
(R-MMU-3928662)
G alpha (12/13) signalling events
(R-MMU-416482)
Gpcr downstream signalling
(R-MMU-388396)
Nervous system development
(R-MMU-9675108)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rhobtb1 gtpase cycle
(R-MMU-9013422)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rhoc gtpase cycle
(R-MMU-9013106)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate rocks
(R-MMU-5627117)
Rhoh gtpase cycle
(R-MMU-9013407)
Sema4d induced cell migration and growth-cone collapse
(R-MMU-416572)
Sema4d in semaphorin signaling
(R-MMU-400685)
Semaphorin interactions
(R-MMU-373755)
Signaling by gpcr
(R-MMU-372790)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Actin cytoskeleton organization
(GO:0030036)
Actomyosin structure organization
(GO:0031032)
Atp binding
(GO:0005524)
Blood vessel diameter maintenance
(GO:0097746)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to testosterone stimulus
(GO:0071394)
Centrosome duplication
(GO:0051298)
Cortical actin cytoskeleton organization
(GO:0030866)
Dendrite morphogenesis
(GO:0048813)
Embryonic morphogenesis
(GO:0048598)
Epithelial to mesenchymal transition
(GO:0001837)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Mitotic cytokinesis
(GO:0000281)
Modulation by host of viral process
(GO:0044788)
Mrna destabilization
(GO:0061157)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of myosin-light-chain-phosphatase activity
(GO:0035509)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of protein localization to lysosome
(GO:0150033)
Neural tube closure
(GO:0001843)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of centrosome duplication
(GO:0010825)
Positive regulation of connective tissue growth factor production
(GO:0032723)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of fibroblast growth factor production
(GO:0090271)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of stress fiber assembly
(GO:0051496)
Postsynaptic actin cytoskeleton organization
(GO:0098974)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to plasma membrane
(GO:0072659)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of angiotensin-activated signaling pathway
(GO:0110061)
Regulation of cell junction assembly
(GO:1901888)
Regulation of cellular response to hypoxia
(GO:1900037)
Regulation of circadian rhythm
(GO:0042752)
Regulation of keratinocyte differentiation
(GO:0045616)
Regulation of nervous system process
(GO:0031644)
Regulation of protein metabolic process
(GO:0051246)
Regulation of synapse maturation
(GO:0090128)
Response to ischemia
(GO:0002931)
Response to transforming growth factor beta
(GO:0071559)
Rho-dependent protein serine/threonine kinase activity
(GO:0072518)
Rho protein signal transduction
(GO:0007266)
Rhythmic process
(GO:0048511)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Smooth muscle contraction
(GO:0006939)
Transferase activity
(GO:0016740)

Other Information

Proteins

Genular Protein ID: 55597779

Symbol: ROCK2_MOUSE

Name: Rho-associated protein kinase 2

UniProtKB Accession Codes:

P70336 A5XDA7 Q8BR64 Q8CBR0

Database IDs:

Citations:

PubMed ID: 8772201

Title: ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.

PubMed ID: 8772201

DOI: 10.1016/0014-5793(96)00811-3

PubMed ID: 17606625

Title: ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program.

PubMed ID: 17606625

DOI: 10.1128/mcb.01735-06

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12832488

Title: Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.

PubMed ID: 12832488

DOI: 10.1128/mcb.23.14.5043-5055.2003

PubMed ID: 15753128

Title: ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles.

PubMed ID: 15753128

DOI: 10.1083/jcb.200411179

PubMed ID: 15699075

Title: Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

PubMed ID: 15699075

DOI: 10.1084/jem.20031877

PubMed ID: 19181962

Title: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.

PubMed ID: 19181962

DOI: 10.1152/ajpheart.01038.2008

PubMed ID: 18718479

Title: A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function.

PubMed ID: 18718479

DOI: 10.1016/j.neuropharm.2008.07.031

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20697158

Title: Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

PubMed ID: 20697158

DOI: 10.1172/jci42856

PubMed ID: 23172836

Title: Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.

PubMed ID: 23172836

DOI: 10.1161/circulationaha.112.135608

PubMed ID: 28089576

Title: Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice.

PubMed ID: 28089576

DOI: 10.1016/j.neuroscience.2016.12.055

Sequence Information:

Length: 1388
Mass: 160586
Checksum: 7A4F331165038161
Sequence:

MSRPPPTGKM PGAPEAAPGD GAGAGRQRKL EALIRDPRSP INVESLLDGL NSLVLDLDFP 
ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR GAFGEVQLVR HKASQKVYAM 
KLLSKFEMIK RSDSAFFWEE RDIMAFANSP WVVQLFCAFQ DDRYLYMVME YMPGGDLVNL 
MSNYDVPEKW AKFYTAEVVL ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD 
ETGMVHCDTA VGTPDYISPE VLKSQGGDGY YGRECDWWSV GVFLFEMLVG DTPFYADSLV 
GTYSKIMDHK NSLCFPEDTE ISKHAKNLIC AFLTDREVRL GRNGVEEIKQ HPFFKNDQWN 
WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP KAFVGNQLPF IGFTYFRENL 
LLSDSPPCRE NDAIQTRKSE ESQEIQKKLY ALEEHLSSEV QAKEELEQKC KSINTRLEKT 
AKELEEEITL RKSVESTLRQ LEREKALLQH KNAEYQRKAD HEADKKRNLE NDVNSLKDQL 
EDLKKRNQSS QISTEKVNQL QKQLDEANAL LRTESDTAAR LRKTQAESSK QIQQLESNNR 
DLQDKNCLLE TAKLKLEKEF INLQSALESE RRDRTHGSEI INDLQGRISG LEEDLKTGKA 
LLAKVELEKR QLQEKLTDLE KEKSNMEIDM TYQLKVIQQS LEQEEAEHKT TKARLADKNK 
IYESIEEAKS EAMKEMEKKL LEERSLKQKV ENLLLEAEKR CSILDCDLKQ SQQKLNELLK 
QKDVLNEDVR NLTLKIEQET QKRCLMQNDL KMQTQQVNTL KMSEKQIKQE NNHLMEMKMN 
LEKQNTELRK ERQDADGQMK ELQDQLEAEQ YFSTLYKTQV RELKEENEEK TKLCKELQQK 
KQDLQDERDS LAAQLEITLT KADSEQLARS IAEEQYSDLE KEKIMKELEI KEMMARHKQE 
LTEKDTTIAS LEETNRTLTS DVANLANEKE ELNNKLKDSQ EQLSKLKDEE MSAAAIKAQF 
EKQLLNERTL KTQAVNKLAE IMNRKEPVKR GSDTDVRRKE KENRKLHMEL KSEREKLTQQ 
MIKYQKELNE MQAQIAEESQ IRIELQMTLD SKDSDIEQLR SQLQALHIGM DSSSIGSGPG 
DAEPDDGFPE SRLEGWLSLP VRNNTKKFGW VKKYVIVSSK KILFYDSEQD KEQSNPYMVL 
DIDKLFHVRP VTQTDVYRAD AKEIPRIFQI LYANEGESKK EPEFPVEPVG EKSNYICHKG 
HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC HKDHMDKKEE IIAPCKVYYD 
ISSAKNLLLL ANSTEEQQKW VSRLVKKIPK KPPAPDPFAR SSPRTSMKIQ QNQSIRRPSR 
QLAPNKPS

Genular Protein ID: 2617577905

Symbol: F8VPK5_MOUSE

Name: N/A

UniProtKB Accession Codes:

F8VPK5

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1388
Mass: 160616
Checksum: 3192FEEA8D903717
Sequence:

MSRPPPTGKM PGAPETAPGD GAGAGRQRKL EALIRDPRSP INVESLLDGL NSLVLDLDFP 
ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR GAFGEVQLVR HKASQKVYAM 
KLLSKFEMIK RSDSAFFWEE RDIMAFANSP WVVQLFCAFQ DDRYLYMVME YMPGGDLVNL 
MSNYDVPEKW AKFYTAEVVL ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD 
ETGMVHCDTA VGTPDYISPE VLKSQGGDGY YGRECDWWSV GVFLFEMLVG DTPFYADSLV 
GTYSKIMDHK NSLCFPEDTE ISKHAKNLIC AFLTDREVRL GRNGVEEIKQ HPFFKNDQWN 
WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP KAFVGNQLPF IGFTYFRENL 
LLSDSPPCRE NDAIQTRKSE ESQEIQKKLY ALEEHLSSEV QAKEELEQKC KSINTRLEKT 
AKELEEEITL RKSVESTLRQ LEREKALLQH KNAEYQRKAD HEADKKRNLE NDVNSLKDQL 
EDLKKRNQSS QISTEKVNQL QKQLDEANAL LRTESDTAAR LRKTQAESSK QIQQLESNNR 
DLQDKNCLLE TAKLKLEKEF INLQSALESE RRDRTHGSEI INDLQGRISG LEEDLKTGKA 
LLAKVELEKR QLQEKLTDLE KEKSNMEIDM TYQLKVIQQS LEQEEAEHKT TKARLADKNK 
IYESIEEAKS EAMKEMEKKL LEERSLKQKV ENLLLEAEKR CSILDCDLKQ SQQKLNELLK 
QKDVLNEDVR NLTLKIEQET QKRCLMQNDL KMQTQQVNTL KMSEKQIKQE NNHLMEMKMN 
LEKQNTELRK ERQDADGQMK ELQDQLEAEQ YFSTLYKTQV RELKEENEEK TKLCKELQQK 
KQDLQDERDS LAAQLEITLT KADSEQLARS IAEEQYSDLE KEKIMKELEI KEMMARHKQE 
LTEKDTTIAS LEETNRTLTS DVANLANEKE ELNNKLKDSQ EQLSKLKDEE MSAAAIKAQF 
EKQLLNERTL KTQAVNKLAE IMNRKEPVKR GSDTDVRRKE KENRKLHMEL KSEREKLTQQ 
MIKYQKELNE MQAQIAEESQ IRIELQMTLD SKDSDIEQLR SQLQALHIGM DSSSIGSGPG 
DAEPDDGFPE SRLEGWLSLP VRNNTKKFGW VKKYVIVSSK KILFYDSEQD KEQSNPYMVL 
DIDKLFHVRP VTQTDVYRAD AKEIPRIFQI LYANEGESKK EPEFPVEPVG EKSNYICHKG 
HEFIPTLYHF PTNCEACMKP LWHMFKPPPA LECRRCHIKC HKDHMDKKEE IIAPCKVYYD 
ISSAKNLLLL ANSTEEQQKW VSRLVKKIPK KPPAPDPFAR SSPRTSMKIQ QNQSIRRPSR 
QLAPNKPS

Genular Protein ID: 914223733

Symbol: Q3TR46_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TR46

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 436
Mass: 49418
Checksum: D6AA01528EE18D20
Sequence:

MSRPPPTGKM PGAPETAPGD GAGAGRQRKL EALIRDPRSP INVESLLDGL NSLVLDLDFP 
ALRKNKNIDN FLNRYEKIVK KIRGLQMKAE DYDVVKVIGR GAFGEVQLVR HKASQKVYAM 
KLLSKFEMIK RSDSAFFWEE RDIMAFANSP WVVQLFCAFQ DDRYLYMVME YMPGGDLVNL 
MSNYDVPEKW AKFYTAEVVL ALDAIHSMGL IHRDVKPDNM LLDKHGHLKL ADFGTCMKMD 
ETGMVHCDTA VGTPDYISPE VLKSQGGDGY YGRECDWWSV GVFLFEMLVG DTPFYADSLV 
GTYSKIMDHK NSLCFPEDTE ISKHAKNLIC AFLTDREVRL GRNGVEEIKQ HPFFKNDQWN 
WDNIRETAAP VVPELSSDID SSNFDDIEDD KGDVETFPIP KAFVGNQLPF IGFTYFRENL 
LLSDSPPCRE NDAIQT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rock2

Associated with

Other Information

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. PubMed ID: 8772201

ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program. PubMed ID: 17606625

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. PubMed ID: 12832488

ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. PubMed ID: 15753128

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. PubMed ID: 15699075

Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. PubMed ID: 19181962

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function. PubMed ID: 18718479

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. PubMed ID: 20697158

Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. PubMed ID: 23172836

Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice. PubMed ID: 28089576

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Database document:

PubMed ID: 8772201

PubMed ID: 17606625

PubMed ID: 16141072

PubMed ID: 12832488

PubMed ID: 15753128

PubMed ID: 15699075

PubMed ID: 19181962

PubMed ID: 18718479

PubMed ID: 21183079

PubMed ID: 20697158

PubMed ID: 23172836

PubMed ID: 28089576

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073