Details for: Rorc

Gene ID: 19885

Symbol: Rorc

Ensembl ID: ENSMUSG00000028150

Description: RAR-related orphan receptor gamma

Associated with

Other Information

Genular Protein ID: 2891181504

Symbol: RORG_MOUSE

Name: Nuclear receptor ROR-gamma

UniProtKB Accession Codes:

P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DrugCentral 1 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneTree 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 2 STRING 1 SUPFAM 2 TreeFam 1 UCSC 3 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8973331

Title: Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element.

PubMed ID: 8973331

DOI: 10.1016/s0378-1119(96)00504-5

PubMed ID: 9403063

Title: Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene.

PubMed ID: 9403063

DOI: 10.1006/geno.1997.4980

PubMed ID: 8614404

Title: TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals.

PubMed ID: 8614404

DOI: 10.1210/mend.9.12.8614404

PubMed ID: 9881970

Title: RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.

PubMed ID: 9881970

DOI: 10.1016/s1074-7613(00)80645-7

PubMed ID: 10602018

Title: RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter.

PubMed ID: 10602018

DOI: 10.1002/(sici)1521-4141(199912)29:12<4072::aid-immu4072>3.0.co;2-e

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14691482

Title: An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.

PubMed ID: 14691482

DOI: 10.1038/ni1022

PubMed ID: 16148126

Title: RORgammat recruits steroid receptor coactivators to ensure thymocyte survival.

PubMed ID: 16148126

DOI: 10.4049/jimmunol.175.6.3800

PubMed ID: 16990136

Title: The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

PubMed ID: 16990136

DOI: 10.1016/j.cell.2006.07.035

PubMed ID: 17476214

Title: Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism.

PubMed ID: 17476214

DOI: 10.1038/nature05767

PubMed ID: 17666523

Title: Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism.

PubMed ID: 17666523

DOI: 10.1152/physiolgenomics.00098.2007

PubMed ID: 18164222

Title: T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.

PubMed ID: 18164222

DOI: 10.1016/j.immuni.2007.11.016

PubMed ID: 18368049

Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

PubMed ID: 18368049

DOI: 10.1038/nature06878

PubMed ID: 19381306

Title: Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.

PubMed ID: 19381306

DOI: 10.1621/nrs.07003

PubMed ID: 19965867

Title: Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.

PubMed ID: 19965867

DOI: 10.1074/jbc.m109.080614

PubMed ID: 21853531

Title: Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma.

PubMed ID: 21853531

DOI: 10.1002/emmm.201100172

PubMed ID: 21499262

Title: Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.

PubMed ID: 21499262

DOI: 10.1038/nature10075

PubMed ID: 22170608

Title: Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

PubMed ID: 22170608

DOI: 10.1038/nature10700

PubMed ID: 22753030

Title: RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo.

PubMed ID: 22753030

DOI: 10.1093/nar/gks630

PubMed ID: 22789990

Title: Action of RORs and their ligands in (patho)physiology.

PubMed ID: 22789990

DOI: 10.1016/j.tem.2012.05.012

PubMed ID: 23562159

Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.

PubMed ID: 23562159

DOI: 10.1016/j.immuni.2013.01.010

PubMed ID: 23723244

Title: Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation.

PubMed ID: 23723244

DOI: 10.1093/nar/gkt447

PubMed ID: 26607793

Title: CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity.

PubMed ID: 26607793

DOI: 10.1016/j.cell.2015.10.068

PubMed ID: 25212631

Title: Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism.

PubMed ID: 25212631

DOI: 10.1002/hep.27437

Sequence Information:

  • Length: 516
  • Mass: 58117
  • Checksum: 218068AF4598A93B
  • Sequence:
    • MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ 
CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK 
QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG LSDGQLPLGA SPDLPEASAC PPGLLRASGS 
GPPYSNTLAK TEVQGASCHL EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG 
EPEQGPDSHC IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR 
EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL LTAGAMEVVL 
VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD FSHFLSALCF SEDEIALYTA 
LVLINANRPG LQEKRRVEHL QYNLELAFHH HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK 
LQIFQHLHPI VVQAAFPPLY KELFSTDVES PEGLSK

Genular Protein ID: 2569447600

Symbol: A0A0R4J096_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J096

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneTree 1 InterPro 7 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 516
  • Mass: 58144
  • Checksum: 03137187ED9B2380
  • Sequence:
    • MDRAPQRHHR TSRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ 
CNVAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLHAEVQK 
QLQQQQQQEQ VAKTPPAGSR GADTLTYTLG LSDGQLPLGA SPDLPEASAC PPGLLRASGS 
GPPYSNTLAK TEVQGASCHL EYSPERGKAE GRDSIYSTDG QLTLGRCGLR FEETRHPELG 
EPEQGPDSHC IPSFCSAPEV PYASLTDIEY LVQNVCKSFR ETCQLRLEDL LRQRTNLFSR 
EEVTSYQRKS MWEMWERCAH HLTEAIQYVV EFAKRLSGFM ELCQNDQIIL LKAGAMEVVL 
VRMCRAYNAN NHTVFFEGKY GGVELFRALG CSELISSIFD FSHFLSALCF SEDEIALYTA 
LVLINANRPG LQEKRRVEHL QYNLELAFHH HLCKTHRQGL LAKLPPKGKL RSLCSQHVEK 
LQIFQHLHPI VVQAAFPPLY KELFSTDVES PEGLSK

Genular Protein ID: 1465488211

Symbol: A0A0G2JGZ6_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0G2JGZ6

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 InterPro 7 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 495
  • Mass: 55723
  • Checksum: 8A32D8882122450D
  • Sequence:
    • MRTQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQC NVAYSCTRQQ NCPIDRTSRN 
RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLHAEVQKQ LQQQQQQEQV AKTPPAGSRG 
ADTLTYTLGL SDGQLPLGAS PDLPEASACP PGLLRASGSG PPYSNTLAKT EVQGASCHLE 
YSPERGKAEG RDSIYSTDGQ LTLGRCGLRF EETRHPELGE PEQGPDSHCI PSFCSAPEVP 
YASLTDIEYL VQNVCKSFRE TCQLRLEDLL RQRTNLFSRE EVTSYQRKSM WEMWERCAHH 
LTEAIQYVVE FAKRLSGFME LCQNDQIILL KAGAMEVVLV RMCRAYNANN HTVFFEGKYG 
GVELFRALGC SELISSIFDF SHFLSALCFS EDEIALYTAL VLINANRPGL QEKRRVEHLQ 
YNLELAFHHH LCKTHRQGLL AKLPPKGKLR SLCSQHVEKL QIFQHLHPIV VQAAFPPLYK 
ELFSTDVESP EGLSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.