Details for: AIF1

Gene ID: 199

Symbol: AIF1

Ensembl ID: ENSG00000204472

Description: allograft inflammatory factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.5847
    Cell Significance Index: -22.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.0561
    Cell Significance Index: -28.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.6805
    Cell Significance Index: -29.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.6231
    Cell Significance Index: -27.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 18.7192
    Cell Significance Index: 345.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.2164
    Cell Significance Index: -22.4600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 11.5787
    Cell Significance Index: 48.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.8199
    Cell Significance Index: -28.9900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 7.3202
    Cell Significance Index: 46.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4241
    Cell Significance Index: -25.3500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 6.3188
    Cell Significance Index: 41.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.7751
    Cell Significance Index: 89.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6377
    Cell Significance Index: -10.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7952
    Cell Significance Index: 115.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6510
    Cell Significance Index: 64.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5490
    Cell Significance Index: 495.7200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.5453
    Cell Significance Index: 3.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5070
    Cell Significance Index: 82.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3697
    Cell Significance Index: 9.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2472
    Cell Significance Index: 29.1500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.2464
    Cell Significance Index: 0.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2198
    Cell Significance Index: 1.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1962
    Cell Significance Index: 21.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1076
    Cell Significance Index: 10.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0875
    Cell Significance Index: 16.6500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0074
    Cell Significance Index: -0.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0122
    Cell Significance Index: -22.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0163
    Cell Significance Index: -12.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0177
    Cell Significance Index: -0.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0339
    Cell Significance Index: -25.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0387
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0404
    Cell Significance Index: -29.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0419
    Cell Significance Index: -8.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0425
    Cell Significance Index: -23.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0434
    Cell Significance Index: -0.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0457
    Cell Significance Index: -29.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0543
    Cell Significance Index: -23.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0645
    Cell Significance Index: -29.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0671
    Cell Significance Index: -3.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0738
    Cell Significance Index: -26.4800
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0830
    Cell Significance Index: -0.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0832
    Cell Significance Index: -23.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0834
    Cell Significance Index: -10.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0967
    Cell Significance Index: -2.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0972
    Cell Significance Index: -4.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1076
    Cell Significance Index: -19.4000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1156
    Cell Significance Index: -1.6900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1192
    Cell Significance Index: -1.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1195
    Cell Significance Index: -16.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1278
    Cell Significance Index: -25.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1360
    Cell Significance Index: -28.6400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1410
    Cell Significance Index: -1.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1482
    Cell Significance Index: -3.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1725
    Cell Significance Index: -20.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1754
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1771
    Cell Significance Index: -30.2400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1814
    Cell Significance Index: -2.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1865
    Cell Significance Index: -22.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1948
    Cell Significance Index: -28.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2101
    Cell Significance Index: -8.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2150
    Cell Significance Index: -5.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2153
    Cell Significance Index: -27.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2226
    Cell Significance Index: -7.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2268
    Cell Significance Index: -23.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2271
    Cell Significance Index: -26.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2435
    Cell Significance Index: -11.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2437
    Cell Significance Index: -14.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2448
    Cell Significance Index: -5.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3084
    Cell Significance Index: -23.6700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3366
    Cell Significance Index: -2.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3516
    Cell Significance Index: -22.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3733
    Cell Significance Index: -27.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3785
    Cell Significance Index: -29.9800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3901
    Cell Significance Index: -3.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3983
    Cell Significance Index: -20.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.4122
    Cell Significance Index: -7.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4276
    Cell Significance Index: -11.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4837
    Cell Significance Index: -27.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4984
    Cell Significance Index: -21.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5049
    Cell Significance Index: -26.5100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5107
    Cell Significance Index: -4.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5169
    Cell Significance Index: -15.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5218
    Cell Significance Index: -24.3300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5464
    Cell Significance Index: -5.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5478
    Cell Significance Index: -8.3200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5678
    Cell Significance Index: -4.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5697
    Cell Significance Index: -9.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5766
    Cell Significance Index: -12.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6163
    Cell Significance Index: -27.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6680
    Cell Significance Index: -24.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7019
    Cell Significance Index: -10.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7212
    Cell Significance Index: -27.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7299
    Cell Significance Index: -25.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7308
    Cell Significance Index: -25.6000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.7605
    Cell Significance Index: -6.9600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.7634
    Cell Significance Index: -13.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7769
    Cell Significance Index: -8.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** AIF1 is a cytoplasmic protein that belongs to the AIF (Apoptosis-Inducing Factor) family, which is characterized by its ability to regulate actin filament dynamics and interact with various signaling molecules. The protein exhibits a unique structure, consisting of three domains: an N-terminal domain, a central domain, and a C-terminal domain. The central domain is responsible for the protein's actin-binding activity, while the N-terminal and C-terminal domains mediate protein-protein interactions. AIF1 is highly expressed in cells of the immune system, including monocytes, macrophages, and dendritic cells, and is involved in the regulation of various cellular processes, including cell migration, proliferation, and differentiation. **Pathways and Functions** AIF1 is involved in multiple signaling pathways, including: 1. **Actin filament dynamics**: AIF1 regulates the assembly and disassembly of actin filaments, which is essential for cell migration, shape changes, and intracellular transport. 2. **Immune response**: AIF1 modulates the activity of immune cells, including monocytes, macrophages, and dendritic cells, through the regulation of cytokine production, chemotaxis, and phagocytosis. 3. **Cell migration**: AIF1 is involved in the regulation of cell migration, including the formation of lamellipodia and the extension of filopodia, which are essential for cell movement and tissue homeostasis. 4. **Signaling pathways**: AIF1 interacts with various signaling molecules, including Rac, which is involved in the regulation of cell migration, proliferation, and differentiation. **Clinical Significance** AIF1 has been implicated in various diseases, including: 1. **Inflammatory disorders**: AIF1 is involved in the regulation of immune responses, and its dysregulation has been linked to inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 2. **Cancer**: AIF1 has been shown to promote cancer cell migration and invasion, suggesting its potential as a therapeutic target. 3. **Neurological disorders**: AIF1 has been implicated in the regulation of neuronal function and has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, AIF1 is a multifunctional protein that plays a critical role in regulating actin filament dynamics, immune responses, and cell migration. Its dysregulation has been linked to various diseases, and further research is needed to fully elucidate its role in human health and disease.

Genular Protein ID: 1084875433

Symbol: AIF1_HUMAN

Name: Allograft inflammatory factor 1

UniProtKB Accession Codes:

P55008 A8K406 O43904 Q9UIV4 Q9UKS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8081366

Title: Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins.

PubMed ID: 8081366

DOI: 10.1093/hmg/3.5.793

PubMed ID: 7590964

Title: Cloning and genomic characterization of LST1: a new gene in the human TNF region.

PubMed ID: 7590964

DOI: 10.1007/bf00179392

PubMed ID: 8912632

Title: cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.

PubMed ID: 8912632

DOI: 10.1006/bbrc.1996.1612

PubMed ID: 8629302

Title: Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts.

PubMed ID: 8629302

DOI: 10.1097/00007890-199605150-00018

PubMed ID: 9367684

Title: Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.

PubMed ID: 9367684

DOI: 10.1006/geno.1997.4963

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15117732

Title: AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF.

PubMed ID: 15117732

DOI: 10.1161/01.atv.0000130024.50058.de

PubMed ID: 16049345

Title: Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies.

PubMed ID: 16049345

DOI: 10.1016/s0002-9440(10)63003-9

PubMed ID: 18699778

Title: Structural and functional characterization of human Iba proteins.

PubMed ID: 18699778

DOI: 10.1111/j.1742-4658.2008.06605.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17011575

Title: X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding.

PubMed ID: 17011575

DOI: 10.1016/j.jmb.2006.09.027

Sequence Information:

  • Length: 147
  • Mass: 16703
  • Checksum: 0104CCF092074E8F
  • Sequence:
    • MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN 
GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM 
ILMYEEKARE KEKPTGPPAK KAISELP

Genular Protein ID: 2565303291

Symbol: I3WTX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3WTX1

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 22116621

Title: NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.

PubMed ID: 22116621

DOI: 10.1093/cvr/cvr309

Sequence Information:

  • Length: 93
  • Mass: 10455
  • Checksum: 4365FCB38F2B7329
  • Sequence:
    • MEFDLNGNGD IDIMSLKRML EKLGVPKTHL ELKKLIGEVS SGSGETFSYP DFLRMMLGKR 
SAILKMILMY EEKAREKEKP TGPPAKKAIS ELP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.