Details for: AIF1

Gene ID: 199

Symbol: AIF1

Ensembl ID: ENSG00000204472

Description: allograft inflammatory factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 7.31
    Marker Score: 5518
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.71
    Marker Score: 4030
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.68
    Marker Score: 4551
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 5.07
    Marker Score: 3074
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.61
    Marker Score: 2379
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.43
    Marker Score: 247635
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.93
    Marker Score: 4498
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.89
    Marker Score: 16176
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.88
    Marker Score: 7562
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.26
    Marker Score: 3256
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.24
    Marker Score: 7820
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 3.04
    Marker Score: 1240
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.01
    Marker Score: 7492
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.89
    Marker Score: 11848
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.88
    Marker Score: 1246
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.88
    Marker Score: 33461
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.83
    Marker Score: 7324.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.77
    Marker Score: 70900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.75
    Marker Score: 690
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.7
    Marker Score: 1957
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.58
    Marker Score: 15665
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.55
    Marker Score: 1243
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.52
    Marker Score: 1049
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.39
    Marker Score: 1315
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.38
    Marker Score: 3376
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2.35
    Marker Score: 1153
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.31
    Marker Score: 2422
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.19
    Marker Score: 2585
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 2.14
    Marker Score: 1059
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 2.05
    Marker Score: 719
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.96
    Marker Score: 1949
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.94
    Marker Score: 1336
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.89
    Marker Score: 1288
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.82
    Marker Score: 2197
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.8
    Marker Score: 577
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.71
    Marker Score: 591
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.57
    Marker Score: 15947
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1135
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.5
    Marker Score: 1503
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.43
    Marker Score: 2553
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.41
    Marker Score: 360
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.41
    Marker Score: 937
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.39
    Marker Score: 731
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.36
    Marker Score: 817
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.35
    Marker Score: 1506
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.28
    Marker Score: 1307
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.24
    Marker Score: 786
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 1.17
    Marker Score: 351.5
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.15
    Marker Score: 322
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.14
    Marker Score: 11283
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4750
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.12
    Marker Score: 681
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.06
    Marker Score: 365
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.03
    Marker Score: 2804
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.03
    Marker Score: 2836
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.93
    Marker Score: 288
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.92
    Marker Score: 460
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5193
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 359
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.89
    Marker Score: 1153
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5258
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.84
    Marker Score: 417
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.84
    Marker Score: 1339
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.83
    Marker Score: 43627
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.82
    Marker Score: 5425
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.8
    Marker Score: 221
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.8
    Marker Score: 581
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.8
    Marker Score: 10503
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.79
    Marker Score: 852
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.79
    Marker Score: 1551
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.77
    Marker Score: 233
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.75
    Marker Score: 673
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.74
    Marker Score: 774
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.73
    Marker Score: 410
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.73
    Marker Score: 243
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.73
    Marker Score: 500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.7
    Marker Score: 672
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.69
    Marker Score: 152
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.69
    Marker Score: 285
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.68
    Marker Score: 455
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.68
    Marker Score: 340
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.67
    Marker Score: 380
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.66
    Marker Score: 174
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.65
    Marker Score: 241.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.65
    Marker Score: 462
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.65
    Marker Score: 705
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.64
    Marker Score: 225
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.64
    Marker Score: 922
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.64
    Marker Score: 1089.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.63
    Marker Score: 282

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Other Information

**Key characteristics:** - AIF1 is a secreted protein that is produced by a variety of cell types. - It is a member of the actin filament family of proteins. - AIF1 is a key regulator of actin filament polymerization and disassembly. - It is also involved in the regulation of cell migration, proliferation, and survival. **Pathways and functions:** - AIF1 is involved in the regulation of cell migration by promoting the disassembly of actin filaments and the formation of new ones. - It is also involved in the regulation of cell proliferation by promoting the activation of the MAPK signaling pathway. - AIF1 is also involved in the regulation of inflammation by promoting the activation of the inflammatory response. - It is involved in the regulation of cell survival by promoting the activation of the PI3K/AKT pathway. **Clinical significance:** - Mutations in AIF1 have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and atherosclerosis. - AIF1 is a potential therapeutic target for these diseases. - AIF1 inhibitors are being investigated as a treatment for cancer and other diseases. **Conclusion:** AIF1 is a key regulator of cell migration, proliferation, and survival. It is involved in a variety of cellular processes, including inflammation, cell migration, and cell survival. Mutations in AIF1 have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and atherosclerosis. AIF1 is a potential therapeutic target for these diseases.

Genular Protein ID: 1084875433

Symbol: AIF1_HUMAN

Name: Allograft inflammatory factor 1

UniProtKB Accession Codes:

P55008 A8K406 O43904 Q9UIV4 Q9UKS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 EPD 1 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8081366

Title: Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins.

PubMed ID: 8081366

DOI: 10.1093/hmg/3.5.793

PubMed ID: 7590964

Title: Cloning and genomic characterization of LST1: a new gene in the human TNF region.

PubMed ID: 7590964

DOI: 10.1007/bf00179392

PubMed ID: 8912632

Title: cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries.

PubMed ID: 8912632

DOI: 10.1006/bbrc.1996.1612

PubMed ID: 8629302

Title: Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts.

PubMed ID: 8629302

DOI: 10.1097/00007890-199605150-00018

PubMed ID: 9367684

Title: Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.

PubMed ID: 9367684

DOI: 10.1006/geno.1997.4963

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15117732

Title: AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF.

PubMed ID: 15117732

DOI: 10.1161/01.atv.0000130024.50058.de

PubMed ID: 16049345

Title: Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies.

PubMed ID: 16049345

DOI: 10.1016/s0002-9440(10)63003-9

PubMed ID: 18699778

Title: Structural and functional characterization of human Iba proteins.

PubMed ID: 18699778

DOI: 10.1111/j.1742-4658.2008.06605.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17011575

Title: X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding.

PubMed ID: 17011575

DOI: 10.1016/j.jmb.2006.09.027

Sequence Information:

  • Length: 147
  • Mass: 16703
  • Checksum: 0104CCF092074E8F
  • Sequence:
    • MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN 
GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM 
ILMYEEKARE KEKPTGPPAK KAISELP

Genular Protein ID: 2565303291

Symbol: I3WTX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3WTX1

Database IDs:

ARBA 8 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 22116621

Title: NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.

PubMed ID: 22116621

DOI: 10.1093/cvr/cvr309

Sequence Information:

  • Length: 93
  • Mass: 10455
  • Checksum: 4365FCB38F2B7329
  • Sequence:
    • MEFDLNGNGD IDIMSLKRML EKLGVPKTHL ELKKLIGEVS SGSGETFSYP DFLRMMLGKR 
SAILKMILMY EEKAREKEKP TGPPAKKAIS ELP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.