Details for: A2M
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 6.68
Marker Score: 21,868 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 5.58
Marker Score: 3,101 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.97
Marker Score: 10,081 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.74
Marker Score: 3,565 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.51
Marker Score: 3,023 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.5
Marker Score: 7,681 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.46
Marker Score: 2,462 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.27
Marker Score: 1,624 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.23
Marker Score: 4,693 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.21
Marker Score: 6,404 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.06
Marker Score: 8,024 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 3
Marker Score: 698 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.89
Marker Score: 1,046 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.86
Marker Score: 4,134 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.77
Marker Score: 1,656 - Cell Name: contractile cell (CL0000183)
Fold Change: 2.77
Marker Score: 1,499 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.74
Marker Score: 1,141 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.6
Marker Score: 3,568 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.56
Marker Score: 2,411 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.52
Marker Score: 4,846 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.48
Marker Score: 2,118 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.42
Marker Score: 987 - Cell Name: muscle cell (CL0000187)
Fold Change: 2.33
Marker Score: 659 - Cell Name: endothelial cell (CL0000115)
Fold Change: 2.3
Marker Score: 2,061 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.28
Marker Score: 4,283 - Cell Name: microglial cell (CL0000129)
Fold Change: 2.27
Marker Score: 4,138 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.23
Marker Score: 579 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.17
Marker Score: 3,681 - Cell Name: pericyte (CL0000669)
Fold Change: 2.15
Marker Score: 1,253 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.1
Marker Score: 1,156 - Cell Name: preosteoblast (CL0007010)
Fold Change: 2.1
Marker Score: 594 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 2
Marker Score: 425 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.99
Marker Score: 10,681 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.93
Marker Score: 799 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.9
Marker Score: 740 - Cell Name: osteoblast (CL0000062)
Fold Change: 1.89
Marker Score: 1,012 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.84
Marker Score: 1,212 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.84
Marker Score: 1,837 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.81
Marker Score: 1,825 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.81
Marker Score: 1,945 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.75
Marker Score: 1,584 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.75
Marker Score: 39,023 - Cell Name: chondrocyte (CL0000138)
Fold Change: 1.74
Marker Score: 785 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.73
Marker Score: 1,089 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.72
Marker Score: 505 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.71
Marker Score: 7,399 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.71
Marker Score: 644 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.69
Marker Score: 422 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.69
Marker Score: 1,808 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.68
Marker Score: 422 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.68
Marker Score: 2,093 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.65
Marker Score: 2,039 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.63
Marker Score: 393 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.63
Marker Score: 356 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.59
Marker Score: 385 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.54
Marker Score: 1,771 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.54
Marker Score: 391 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.52
Marker Score: 420 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,522 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.46
Marker Score: 460 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.45
Marker Score: 1,396 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.41
Marker Score: 9,064 - Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.4
Marker Score: 356 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.39
Marker Score: 3,611 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.38
Marker Score: 321 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.38
Marker Score: 4,892 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.34
Marker Score: 2,541 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.32
Marker Score: 5,692 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.21
Marker Score: 804 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.19
Marker Score: 314 - Cell Name: macrophage (CL0000235)
Fold Change: 1.18
Marker Score: 1,309 - Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.16
Marker Score: 308 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.15
Marker Score: 1,316 - Cell Name: lymphocyte (CL0000542)
Fold Change: 1.15
Marker Score: 579 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.14
Marker Score: 777 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.12
Marker Score: 18,048 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.1
Marker Score: 5,411 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.05
Marker Score: 1,372 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,745 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,970 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,399 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.98
Marker Score: 17,340 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.97
Marker Score: 1,982 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.97
Marker Score: 218 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.96
Marker Score: 601 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.95
Marker Score: 2,983 - Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.93
Marker Score: 263 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.93
Marker Score: 425 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,732 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,961 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.86
Marker Score: 655 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.85
Marker Score: 323 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.83
Marker Score: 1,004 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.81
Marker Score: 12,660 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.8
Marker Score: 970 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.79
Marker Score: 322 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1,250 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.77
Marker Score: 437
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2501749604
Symbol: A2MG_HUMAN
Name: Alpha-2-macroglobulin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2581245
Title: Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.
PubMed ID: 2581245
PubMed ID: 15611997
Title: Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma.
PubMed ID: 15611997
DOI: 10.1002/pros.20183
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1374237
Title: Structure of the human alpha-2 macroglobulin gene and its promotor.
PubMed ID: 1374237
PubMed ID: 6203908
Title: Primary structure of human alpha 2-macroglobulin. V. The complete structure.
PubMed ID: 6203908
PubMed ID: 2430963
Title: Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.
PubMed ID: 2430963
PubMed ID: 1692292
Title: A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.
PubMed ID: 1692292
PubMed ID: 1370808
Title: Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.
PubMed ID: 1370808
DOI: 10.1007/bf00197266
PubMed ID: 2408344
Title: Human alpha 2-macroglobulin gene is located on chromosome 12.
PubMed ID: 2408344
DOI: 10.1007/bf01534685
PubMed ID: 6167263
Title: Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.
PubMed ID: 6167263
PubMed ID: 6165619
Title: Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.
PubMed ID: 6165619
PubMed ID: 6172288
Title: Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.
PubMed ID: 6172288
PubMed ID: 6195065
Title: Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.
PubMed ID: 6195065
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 9865955
Title: Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin.
PubMed ID: 9865955
PubMed ID: 17608619
Title: Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
PubMed ID: 17608619
DOI: 10.1042/bj20070764
PubMed ID: 1707161
Title: Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene.
PubMed ID: 1707161
Sequence Information:
- Length: 1474
- Mass: 163291
- Checksum: 0A46DF09EFD3CF40
- Sequence:
MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL LSYLNETVTV SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV MFLTVQVKGP TQEFKKRTTV MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS MDENFHPLNE LIPLVYIQDP KGNRIAQWQS FQLEGGLKQF SFPLSSEPFQ GSYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT ILEEEMNVSV CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEKF SGQLNSHGCF YQQVKTKVFQ LKRKEYEMKL HTEAQIQEEG TVVELTGRQS SEITRTITKL SFVKVDSHFR QGIPFFGQVR LVDGKGVPIP NKVIFIRGNE ANYYSNATTD EHGLVQFSIN TTNVMGTSLT VRVNYKDRSP CYGYQWVSEE HEEAHHTAYL VFSPSKSFVH LEPMSHELPC GHTQTVQAHY ILNGGTLLGL KKLSFYYLIM AKGGIVRTGT HGLLVKQEDM KGHFSISIPV KSDIAPVARL LIYAVLPTGD VIGDSAKYDV ENCLANKVDL SFSPSQSLPA SHAHLRVTAA PQSVCALRAV DQSVLLMKPD AELSASSVYN LLPEKDLTGF PGPLNDQDNE DCINRHNVYI NGITYTPVSS TNEKDMYSFL EDMGLKAFTN SKIRKPKMCP QLQQYEMHGP EGLRVGFYES DVMGRGHARL VHVEEPHTET VRKYFPETWI WDLVVVNSAG VAEVGVTVPD TITEWKAGAF CLSEDAGLGI SSTASLRAFQ PFFVELTMPY SVIRGEAFTL KATVLNYLPK CIRVSVQLEA SPAFLAVPVE KEQAPHCICA NGRQTVSWAV TPKSLGNVNF TVSAEALESQ ELCGTEVPSV PEHGRKDTVI KPLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV LGDILGSAMQ NTQNLLQMPY GCGEQNMVLF APNIYVLDYL NETQQLTPEI KSKAIGYLNT GYQRQLNYKH YDGSYSTFGE RYGRNQGNTW LTAFVLKTFA QARAYIFIDE AHITQALIWL SQRQKDNGCF RSSGSLLNNA IKGGVEDEVT LSAYITIALL EIPLTVTHPV VRNALFCLES AWKTAQEGDH GSHVYTKALL AYAFALAGNQ DKRKEVLKSL NEEAVKKDNS VHWERPQKPK APVGHFYEPQ APSAEVEMTS YVLLAYLTAQ PAPTSEDLTS ATNIVKWITK QQNAQGGFSS TQDTVVALHA LSKYGAATFT RTGKAAQVTI QSSGTFSSKF QVDNNNRLLL QQVSLPELPG EYSMKVTGEG CVYLQTSLKY NILPEKEEFP FALGVQTLPQ TCDEPKAHTS FQISLSVSYT GSRSASNMAI VDVKMVSGFI PLKPTVKMLE RSNHVSRTEV SSNHVLIYLD KVSNQTLSLF FTVLQDVPVR DLKPAIVKVY DYYETDEFAI AEYNAPCSKD LGNA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.