Details for: A2M

Gene ID: 2

Symbol: A2M

Ensembl ID: ENSG00000175899

Description: alpha-2-macroglobulin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 345.0283
    Cell Significance Index: -53.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 122.4428
    Cell Significance Index: -50.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.6672
    Cell Significance Index: -50.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.6147
    Cell Significance Index: -53.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.9919
    Cell Significance Index: -52.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6225
    Cell Significance Index: -53.7600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 9.3830
    Cell Significance Index: 58.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.8620
    Cell Significance Index: 149.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.7084
    Cell Significance Index: 76.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.6028
    Cell Significance Index: 116.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.4869
    Cell Significance Index: 78.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 5.4455
    Cell Significance Index: 91.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1753
    Cell Significance Index: 630.1500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.8492
    Cell Significance Index: 17.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.3455
    Cell Significance Index: 610.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1049
    Cell Significance Index: 29.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0842
    Cell Significance Index: 83.2000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.9539
    Cell Significance Index: 3.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5263
    Cell Significance Index: 3.1800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4776
    Cell Significance Index: 7.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2771
    Cell Significance Index: 38.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1321
    Cell Significance Index: 1.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0679
    Cell Significance Index: 1.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0501
    Cell Significance Index: 5.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0389
    Cell Significance Index: 11.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0298
    Cell Significance Index: 54.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0295
    Cell Significance Index: 5.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0174
    Cell Significance Index: 26.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0134
    Cell Significance Index: -8.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0254
    Cell Significance Index: -16.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0303
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0312
    Cell Significance Index: -23.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0521
    Cell Significance Index: -39.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0548
    Cell Significance Index: -7.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0585
    Cell Significance Index: -20.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0615
    Cell Significance Index: -11.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0630
    Cell Significance Index: -46.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0634
    Cell Significance Index: -35.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0874
    Cell Significance Index: -8.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0911
    Cell Significance Index: -49.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1101
    Cell Significance Index: -48.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1831
    Cell Significance Index: -38.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1876
    Cell Significance Index: -32.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2060
    Cell Significance Index: -25.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2319
    Cell Significance Index: -24.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2384
    Cell Significance Index: -34.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2683
    Cell Significance Index: -7.1900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2896
    Cell Significance Index: -2.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3018
    Cell Significance Index: -38.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3495
    Cell Significance Index: -40.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4466
    Cell Significance Index: -50.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4960
    Cell Significance Index: -23.3100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.5296
    Cell Significance Index: -3.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5371
    Cell Significance Index: -4.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5392
    Cell Significance Index: -40.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5665
    Cell Significance Index: -16.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5894
    Cell Significance Index: -46.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6052
    Cell Significance Index: -33.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6316
    Cell Significance Index: -42.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6888
    Cell Significance Index: -34.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7298
    Cell Significance Index: -10.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7556
    Cell Significance Index: -48.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8035
    Cell Significance Index: -50.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8041
    Cell Significance Index: -49.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8287
    Cell Significance Index: -26.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8426
    Cell Significance Index: -21.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9546
    Cell Significance Index: -50.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9591
    Cell Significance Index: -49.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9915
    Cell Significance Index: -43.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9971
    Cell Significance Index: -46.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0150
    Cell Significance Index: -19.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1024
    Cell Significance Index: -49.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.1144
    Cell Significance Index: -18.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1535
    Cell Significance Index: -13.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.1725
    Cell Significance Index: -44.4000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.1784
    Cell Significance Index: -15.1100
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -1.2035
    Cell Significance Index: -16.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3029
    Cell Significance Index: -47.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3406
    Cell Significance Index: -46.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.3681
    Cell Significance Index: -32.8100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -1.3863
    Cell Significance Index: -17.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4144
    Cell Significance Index: -49.5500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -1.4209
    Cell Significance Index: -19.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.4303
    Cell Significance Index: -58.6100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.4471
    Cell Significance Index: -21.0100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.4530
    Cell Significance Index: -20.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5003
    Cell Significance Index: -49.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5439
    Cell Significance Index: -49.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.5523
    Cell Significance Index: -37.6000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5621
    Cell Significance Index: -46.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.6122
    Cell Significance Index: -56.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.6438
    Cell Significance Index: -46.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.6821
    Cell Significance Index: -49.4000
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -1.7332
    Cell Significance Index: -12.9800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -1.7642
    Cell Significance Index: -6.1400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -1.8404
    Cell Significance Index: -22.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.8404
    Cell Significance Index: -49.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.8535
    Cell Significance Index: -46.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** A2M is characterized by its ability to bind to and inhibit a diverse array of proteases, including: 1. Serine proteases: A2M binds to and inhibits serine proteases, such as trypsin, chymotrypsin, and elastase, which are involved in inflammation and tissue remodeling. 2. Cysteine proteases: A2M also binds to and inhibits cysteine proteases, such as cathepsin B and cathepsin L, which are involved in protein degradation and immune response. 3. Aspartic proteases: A2M binds to and inhibits aspartic proteases, such as papain and pepsin, which are involved in protein degradation and immune response. A2M is also characterized by its ability to regulate various inflammatory responses, including: 1. Acute-phase response: A2M is induced during acute-phase responses, such as inflammation and infection, and plays a crucial role in regulating the immune response. 2. Acute inflammatory response to antigenic stimulus: A2M binds to and inhibits inflammatory mediators, such as cytokines and chemokines, which are involved in the acute inflammatory response. 3. Negative regulation of complement activation: A2M binds to and inhibits complement components, such as C3b and C4b, which are involved in the complement cascade. **Pathways and Functions** A2M is involved in various biological pathways, including: 1. Acute-phase response: A2M regulates the acute-phase response by binding to and inhibiting inflammatory mediators. 2. Acute inflammatory response to antigenic stimulus: A2M regulates the acute inflammatory response by binding to and inhibiting inflammatory mediators. 3. Endopeptidase inhibitor activity: A2M inhibits endopeptidases, which are involved in protein degradation and immune response. 4. Enzyme binding: A2M binds to and inhibits enzymes, such as proteases and lipases, which are involved in inflammation and tissue remodeling. 5. Growth factor binding: A2M binds to and regulates growth factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), which are involved in cell growth and differentiation. **Clinical Significance** A2M has significant clinical implications in various diseases, including: 1. Inflammatory disorders: A2M regulates the acute inflammatory response and is involved in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis and asthma. 2. Cancer: A2M regulates protease activity and is involved in the pathogenesis of cancer. 3. Neurodegenerative disorders: A2M regulates protease activity and is involved in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. Cardiovascular disease: A2M regulates protease activity and is involved in the pathogenesis of cardiovascular disease. In conclusion, alpha-2-macroglobulin is a multifaceted protease inhibitor that plays a crucial role in various biological processes, including inflammation, immune response, and tissue remodeling. Its clinical significance is evident in various diseases, including inflammatory disorders, cancer, neurodegenerative disorders, and cardiovascular disease. Further research on A2M is necessary to fully understand its role in human health and disease.

Genular Protein ID: 2501749604

Symbol: A2MG_HUMAN

Name: Alpha-2-macroglobulin

UniProtKB Accession Codes:

P01023 Q13677 Q59F47 Q5QTS0 Q68DN2 Q6PIY3 Q6PN97

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 12 EMBL 12 EMDB 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 13 PDBsum 13 PIR 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2581245

Title: Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.

PubMed ID: 2581245

DOI: 10.1073/pnas.82.8.2282

PubMed ID: 15611997

Title: Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma.

PubMed ID: 15611997

DOI: 10.1002/pros.20183

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1374237

Title: Structure of the human alpha-2 macroglobulin gene and its promotor.

PubMed ID: 1374237

DOI: 10.1016/0006-291x(92)90631-t

PubMed ID: 6203908

Title: Primary structure of human alpha 2-macroglobulin. V. The complete structure.

PubMed ID: 6203908

DOI: 10.1016/s0021-9258(17)39730-2

PubMed ID: 2430963

Title: Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.

PubMed ID: 2430963

DOI: 10.1016/s0021-9258(18)66643-8

PubMed ID: 1692292

Title: A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.

PubMed ID: 1692292

DOI: 10.1016/0014-5793(90)80226-9

PubMed ID: 1370808

Title: Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.

PubMed ID: 1370808

DOI: 10.1007/bf00197266

PubMed ID: 2408344

Title: Human alpha 2-macroglobulin gene is located on chromosome 12.

PubMed ID: 2408344

DOI: 10.1007/bf01534685

PubMed ID: 6167263

Title: Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.

PubMed ID: 6167263

DOI: 10.1016/s0006-291x(81)80055-1

PubMed ID: 6165619

Title: Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.

PubMed ID: 6165619

DOI: 10.1016/0014-5793(81)80197-4

PubMed ID: 6172288

Title: Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.

PubMed ID: 6172288

DOI: 10.1016/0014-5793(81)80804-6

PubMed ID: 6195065

Title: Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.

PubMed ID: 6195065

DOI: 10.1515/bchm2.1983.364.2.1297

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9865955

Title: Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin.

PubMed ID: 9865955

DOI: 10.1002/pro.5560071214

PubMed ID: 17608619

Title: Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.

PubMed ID: 17608619

DOI: 10.1042/bj20070764

PubMed ID: 1707161

Title: Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene.

PubMed ID: 1707161

DOI: 10.1093/nar/19.1.198-a

Sequence Information:

  • Length: 1474
  • Mass: 163291
  • Checksum: 0A46DF09EFD3CF40
  • Sequence:
    • MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL LSYLNETVTV 
SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV MFLTVQVKGP TQEFKKRTTV 
MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS MDENFHPLNE LIPLVYIQDP KGNRIAQWQS 
FQLEGGLKQF SFPLSSEPFQ GSYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT 
ILEEEMNVSV CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEKF SGQLNSHGCF 
YQQVKTKVFQ LKRKEYEMKL HTEAQIQEEG TVVELTGRQS SEITRTITKL SFVKVDSHFR 
QGIPFFGQVR LVDGKGVPIP NKVIFIRGNE ANYYSNATTD EHGLVQFSIN TTNVMGTSLT 
VRVNYKDRSP CYGYQWVSEE HEEAHHTAYL VFSPSKSFVH LEPMSHELPC GHTQTVQAHY 
ILNGGTLLGL KKLSFYYLIM AKGGIVRTGT HGLLVKQEDM KGHFSISIPV KSDIAPVARL 
LIYAVLPTGD VIGDSAKYDV ENCLANKVDL SFSPSQSLPA SHAHLRVTAA PQSVCALRAV 
DQSVLLMKPD AELSASSVYN LLPEKDLTGF PGPLNDQDNE DCINRHNVYI NGITYTPVSS 
TNEKDMYSFL EDMGLKAFTN SKIRKPKMCP QLQQYEMHGP EGLRVGFYES DVMGRGHARL 
VHVEEPHTET VRKYFPETWI WDLVVVNSAG VAEVGVTVPD TITEWKAGAF CLSEDAGLGI 
SSTASLRAFQ PFFVELTMPY SVIRGEAFTL KATVLNYLPK CIRVSVQLEA SPAFLAVPVE 
KEQAPHCICA NGRQTVSWAV TPKSLGNVNF TVSAEALESQ ELCGTEVPSV PEHGRKDTVI 
KPLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV LGDILGSAMQ 
NTQNLLQMPY GCGEQNMVLF APNIYVLDYL NETQQLTPEI KSKAIGYLNT GYQRQLNYKH 
YDGSYSTFGE RYGRNQGNTW LTAFVLKTFA QARAYIFIDE AHITQALIWL SQRQKDNGCF 
RSSGSLLNNA IKGGVEDEVT LSAYITIALL EIPLTVTHPV VRNALFCLES AWKTAQEGDH 
GSHVYTKALL AYAFALAGNQ DKRKEVLKSL NEEAVKKDNS VHWERPQKPK APVGHFYEPQ 
APSAEVEMTS YVLLAYLTAQ PAPTSEDLTS ATNIVKWITK QQNAQGGFSS TQDTVVALHA 
LSKYGAATFT RTGKAAQVTI QSSGTFSSKF QVDNNNRLLL QQVSLPELPG EYSMKVTGEG 
CVYLQTSLKY NILPEKEEFP FALGVQTLPQ TCDEPKAHTS FQISLSVSYT GSRSASNMAI 
VDVKMVSGFI PLKPTVKMLE RSNHVSRTEV SSNHVLIYLD KVSNQTLSLF FTVLQDVPVR 
DLKPAIVKVY DYYETDEFAI AEYNAPCSKD LGNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.