Details for: A2M

Gene ID: 2

Symbol: A2M

Ensembl ID: ENSG00000175899

Description: alpha-2-macroglobulin

Associated with

Cells (max top 100)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.68
    Marker Score: 21868
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 5.58
    Marker Score: 3101
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.97
    Marker Score: 10081
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.74
    Marker Score: 3565
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.51
    Marker Score: 3023
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.5
    Marker Score: 7680.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.46
    Marker Score: 2462
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.27
    Marker Score: 1624
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.23
    Marker Score: 4693
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.21
    Marker Score: 6404
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.06
    Marker Score: 8024
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3
    Marker Score: 698
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.89
    Marker Score: 1046
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.86
    Marker Score: 4134
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.77
    Marker Score: 1656
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.77
    Marker Score: 1499
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.74
    Marker Score: 1141
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.6
    Marker Score: 3568
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.56
    Marker Score: 2411
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.52
    Marker Score: 4846
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.48
    Marker Score: 2118
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.42
    Marker Score: 987
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.33
    Marker Score: 659
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.3
    Marker Score: 2061
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.28
    Marker Score: 4283
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.27
    Marker Score: 4138
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.23
    Marker Score: 579
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.17
    Marker Score: 3681
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.15
    Marker Score: 1253
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.1
    Marker Score: 1156
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.1
    Marker Score: 594
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2
    Marker Score: 425
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.99
    Marker Score: 10680.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.93
    Marker Score: 799
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.9
    Marker Score: 740
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.89
    Marker Score: 1012
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.84
    Marker Score: 1212
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.84
    Marker Score: 1837
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.81
    Marker Score: 1825
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.81
    Marker Score: 1945
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.75
    Marker Score: 1584
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.75
    Marker Score: 39023
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.74
    Marker Score: 785
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.73
    Marker Score: 1089
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.72
    Marker Score: 505
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.71
    Marker Score: 7399
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.71
    Marker Score: 644
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.69
    Marker Score: 422
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.69
    Marker Score: 1808
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.68
    Marker Score: 422
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.68
    Marker Score: 2093
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.65
    Marker Score: 2039
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.63
    Marker Score: 392.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.63
    Marker Score: 356
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.59
    Marker Score: 385
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.54
    Marker Score: 1771
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.54
    Marker Score: 391
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.52
    Marker Score: 419.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167522
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.46
    Marker Score: 460
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.45
    Marker Score: 1396
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.41
    Marker Score: 9064
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.4
    Marker Score: 356
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.39
    Marker Score: 3611
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.38
    Marker Score: 321
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.38
    Marker Score: 4892
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2541
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.32
    Marker Score: 5692
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.21
    Marker Score: 804
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.19
    Marker Score: 314
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.18
    Marker Score: 1309
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.16
    Marker Score: 308
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.15
    Marker Score: 1316
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.15
    Marker Score: 579
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.14
    Marker Score: 777
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.12
    Marker Score: 18048
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.1
    Marker Score: 5410.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.05
    Marker Score: 1372
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71745
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47970
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30399
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.98
    Marker Score: 17340
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1982
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.97
    Marker Score: 218
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.96
    Marker Score: 601
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.95
    Marker Score: 2983
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.93
    Marker Score: 263
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.93
    Marker Score: 425
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4961
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 655
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.85
    Marker Score: 323
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 1004
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12659.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.8
    Marker Score: 970
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.79
    Marker Score: 322
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1250
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.77
    Marker Score: 437
# Summary The A2M gene encodes a protein called alpha-2-macroglobulin (A2M). A2M is a secreted protein that plays a critical role in the regulation of blood clot formation and inflammation. It is expressed in a variety of cell types, including hepatoblasts, endothelial cells, pericytes, and macrophages. # Key characteristics * A2M is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a member of the immunoglobulin superfamily. * A2M is produced by a variety of cell types in response to injury or inflammation. * It is a key regulator of the coagulation cascade, which is responsible for the formation of blood clots. * A2M also plays a role in the regulation of inflammation and cell migration. # Pathways and functions * A2M is produced in response to injury or inflammation. * It binds to collagen and elastin fibers in the extracellular matrix, which is a protein that provides structural support for blood vessels. * This binding prevents the formation of new blood clots and helps to stabilize existing clots. * A2M also binds to platelets, which are small blood cells that play a key role in blood clotting. * This binding activates platelets and promotes the formation of blood clots. * A2M is also involved in the regulation of inflammation. * It can inhibit the activity of serine-type endopeptidases, which are enzymes that break down proteins. * This inhibition helps to prevent the degradation of A2M and other proteins that are involved in blood clot formation. # Clinical significance A2M is a clinically significant protein in patients with cardiovascular disease. In people with cardiovascular disease, high levels of A2M have been linked to increased risk of thrombosis. This is because A2M can promote the formation of blood clots, which can lead to heart attack and stroke. A2M can be measured in the blood to assess the risk of cardiovascular disease. High levels of A2M have been shown to be associated with an increased risk of cardiovascular events. A2M can be a target for therapy in patients with cardiovascular disease. There are a number of drugs that can block the activity of A2M, which can help to prevent the formation of blood clots and reduce the risk of cardiovascular events.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.