A2M | ENSG00000175899 | NCBI 2

Details for: A2M

Gene ID: 2

Symbol: A2M

Ensembl ID: ENSG00000175899

Description: alpha-2-macroglobulin

Associated with

Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Formation of fibrin clot (clotting cascade)
(R-HSA-140877)
Hdl assembly
(R-HSA-8963896)
Hemostasis
(R-HSA-109582)
Intrinsic pathway of fibrin clot formation
(R-HSA-140837)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Transport of small molecules
(R-HSA-382551)
Acute-phase response
(GO:0006953)
Acute inflammatory response to antigenic stimulus
(GO:0002438)
Blood microparticle
(GO:0072562)
Brain-derived neurotrophic factor binding
(GO:0048403)
Calcium-dependent protein binding
(GO:0048306)
Collagen-containing extracellular matrix
(GO:0062023)
Embryonic liver development
(GO:1990402)
Endopeptidase inhibitor activity
(GO:0004866)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor binding
(GO:0019838)
Identical protein binding
(GO:0042802)
Interleukin-1 binding
(GO:0019966)
Interleukin-8 binding
(GO:0019959)
Luteinization
(GO:0001553)
Negative regulation of complement activation, lectin pathway
(GO:0001869)
Nerve growth factor binding
(GO:0048406)
Platelet alpha granule lumen
(GO:0031093)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Response to carbon dioxide
(GO:0010037)
Response to glucocorticoid
(GO:0051384)
Response to nutrient
(GO:0007584)
Response to prostaglandin e
(GO:0034695)
Serine-type endopeptidase inhibitor activity
(GO:0004867)
Signaling receptor binding
(GO:0005102)
Stem cell differentiation
(GO:0048863)
Tumor necrosis factor binding
(GO:0043120)

Other Information

Proteins

Alpha-2-macroglobulin

Genular Protein ID: 2501749604

Symbol: A2MG_HUMAN

Name: Alpha-2-macroglobulin

UniProtKB Accession Codes:

P01023 Q13677 Q59F47 Q5QTS0 Q68DN2 Q6PIY3 Q6PN97

Database IDs:

Citations:

PubMed ID: 2581245

Title: Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.

PubMed ID: 2581245

DOI: 10.1073/pnas.82.8.2282

PubMed ID: 15611997

Title: Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma.

PubMed ID: 15611997

DOI: 10.1002/pros.20183

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1374237

Title: Structure of the human alpha-2 macroglobulin gene and its promotor.

PubMed ID: 1374237

DOI: 10.1016/0006-291x(92)90631-t

PubMed ID: 6203908

Title: Primary structure of human alpha 2-macroglobulin. V. The complete structure.

PubMed ID: 6203908

DOI: 10.1016/s0021-9258(17)39730-2

PubMed ID: 2430963

Title: Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.

PubMed ID: 2430963

DOI: 10.1016/s0021-9258(18)66643-8

PubMed ID: 1692292

Title: A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.

PubMed ID: 1692292

DOI: 10.1016/0014-5793(90)80226-9

PubMed ID: 1370808

Title: Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.

PubMed ID: 1370808

DOI: 10.1007/bf00197266

PubMed ID: 2408344

Title: Human alpha 2-macroglobulin gene is located on chromosome 12.

PubMed ID: 2408344

DOI: 10.1007/bf01534685

PubMed ID: 6167263

Title: Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.

PubMed ID: 6167263

DOI: 10.1016/s0006-291x(81)80055-1

PubMed ID: 6165619

Title: Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.

PubMed ID: 6165619

DOI: 10.1016/0014-5793(81)80197-4

PubMed ID: 6172288

Title: Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.

PubMed ID: 6172288

DOI: 10.1016/0014-5793(81)80804-6

PubMed ID: 6195065

Title: Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.

PubMed ID: 6195065

DOI: 10.1515/bchm2.1983.364.2.1297

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9865955

Title: Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin.

PubMed ID: 9865955

DOI: 10.1002/pro.5560071214

PubMed ID: 17608619

Title: Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.

PubMed ID: 17608619

DOI: 10.1042/bj20070764

PubMed ID: 1707161

Title: Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene.

PubMed ID: 1707161

DOI: 10.1093/nar/19.1.198-a

Sequence Information:

Length: 1474
Mass: 163291
Checksum: 0A46DF09EFD3CF40
Sequence:

MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL LSYLNETVTV 
SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV MFLTVQVKGP TQEFKKRTTV 
MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS MDENFHPLNE LIPLVYIQDP KGNRIAQWQS 
FQLEGGLKQF SFPLSSEPFQ GSYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT 
ILEEEMNVSV CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEKF SGQLNSHGCF 
YQQVKTKVFQ LKRKEYEMKL HTEAQIQEEG TVVELTGRQS SEITRTITKL SFVKVDSHFR 
QGIPFFGQVR LVDGKGVPIP NKVIFIRGNE ANYYSNATTD EHGLVQFSIN TTNVMGTSLT 
VRVNYKDRSP CYGYQWVSEE HEEAHHTAYL VFSPSKSFVH LEPMSHELPC GHTQTVQAHY 
ILNGGTLLGL KKLSFYYLIM AKGGIVRTGT HGLLVKQEDM KGHFSISIPV KSDIAPVARL 
LIYAVLPTGD VIGDSAKYDV ENCLANKVDL SFSPSQSLPA SHAHLRVTAA PQSVCALRAV 
DQSVLLMKPD AELSASSVYN LLPEKDLTGF PGPLNDQDNE DCINRHNVYI NGITYTPVSS 
TNEKDMYSFL EDMGLKAFTN SKIRKPKMCP QLQQYEMHGP EGLRVGFYES DVMGRGHARL 
VHVEEPHTET VRKYFPETWI WDLVVVNSAG VAEVGVTVPD TITEWKAGAF CLSEDAGLGI 
SSTASLRAFQ PFFVELTMPY SVIRGEAFTL KATVLNYLPK CIRVSVQLEA SPAFLAVPVE 
KEQAPHCICA NGRQTVSWAV TPKSLGNVNF TVSAEALESQ ELCGTEVPSV PEHGRKDTVI 
KPLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV LGDILGSAMQ 
NTQNLLQMPY GCGEQNMVLF APNIYVLDYL NETQQLTPEI KSKAIGYLNT GYQRQLNYKH 
YDGSYSTFGE RYGRNQGNTW LTAFVLKTFA QARAYIFIDE AHITQALIWL SQRQKDNGCF 
RSSGSLLNNA IKGGVEDEVT LSAYITIALL EIPLTVTHPV VRNALFCLES AWKTAQEGDH 
GSHVYTKALL AYAFALAGNQ DKRKEVLKSL NEEAVKKDNS VHWERPQKPK APVGHFYEPQ 
APSAEVEMTS YVLLAYLTAQ PAPTSEDLTS ATNIVKWITK QQNAQGGFSS TQDTVVALHA 
LSKYGAATFT RTGKAAQVTI QSSGTFSSKF QVDNNNRLLL QQVSLPELPG EYSMKVTGEG 
CVYLQTSLKY NILPEKEEFP FALGVQTLPQ TCDEPKAHTS FQISLSVSYT GSRSASNMAI 
VDVKMVSGFI PLKPTVKMLE RSNHVSRTEV SSNHVLIYLD KVSNQTLSLF FTVLQDVPVR 
DLKPAIVKVY DYYETDEFAI AEYNAPCSKD LGNA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: A2M

Associated with

Other Information

Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus. PubMed ID: 2581245

Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma. PubMed ID: 15611997

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of the human alpha-2 macroglobulin gene and its promotor. PubMed ID: 1374237

Primary structure of human alpha 2-macroglobulin. V. The complete structure. PubMed ID: 6203908

Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit. PubMed ID: 2430963

A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin. PubMed ID: 1692292

Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site. PubMed ID: 1370808

Human alpha 2-macroglobulin gene is located on chromosome 12. PubMed ID: 2408344

Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase. PubMed ID: 6167263

Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex. PubMed ID: 6165619

Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin. PubMed ID: 6172288

Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region. PubMed ID: 6195065

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin. PubMed ID: 9865955

Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3. PubMed ID: 17608619

Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene. PubMed ID: 1707161