Details for: A2M
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: fibroblast of lung (CL0002553)
CSI Score: 19.3 - Cell Name: blood vessel endothelial cell (CL0000071)
CSI Score: 13.9 - Cell Name: endothelial cell (CL0000115)
CSI Score: 13.8 - Cell Name: myoepithelial cell (CL0000185)
CSI Score: 13.2 - Cell Name: endothelial cell of artery (CL1000413)
CSI Score: 11.5 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
CSI Score: 11.4 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
CSI Score: 9.5 - Cell Name: gut endothelial cell (CL0000131)
CSI Score: 9.1 - Cell Name: alveolar type 1 fibroblast cell (CL4028004)
CSI Score: 8.9 - Cell Name: mononuclear phagocyte (CL0000113)
CSI Score: 8.7 - Cell Name: retina horizontal cell (CL0000745)
CSI Score: 8.4 - Cell Name: hepatocyte (CL0000182)
CSI Score: 8.2 - Cell Name: macrophage (CL0000235)
CSI Score: 8.1 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
CSI Score: 7.8 - Cell Name: endothelial cell of vascular tree (CL0002139)
CSI Score: 7.5 - Cell Name: smooth muscle cell (CL0000192)
CSI Score: 7.3 - Cell Name: myofibroblast cell (CL0000186)
CSI Score: 7.2 - Cell Name: microglial cell (CL0000129)
CSI Score: 6.6 - Cell Name: renal interstitial pericyte (CL1001318)
CSI Score: 6.2 - Cell Name: Kupffer cell (CL0000091)
CSI Score: 6.1 - Cell Name: muscle cell (CL0000187)
CSI Score: 6.1 - Cell Name: lung pericyte (CL0009089)
CSI Score: 5.9 - Cell Name: central nervous system macrophage (CL0000878)
CSI Score: 5.8 - Cell Name: capillary endothelial cell (CL0002144)
CSI Score: 5.7 - Cell Name: myeloid cell (CL0000763)
CSI Score: 5.4 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
CSI Score: 5.2 - Cell Name: exhausted T cell (CL0011025)
CSI Score: 4.9 - Cell Name: contractile cell (CL0000183)
CSI Score: 4.9 - Cell Name: regular atrial cardiac myocyte (CL0002129)
CSI Score: 4.9 - Cell Name: hematopoietic cell (CL0000988)
CSI Score: 4.9 - Cell Name: myeloid leukocyte (CL0000766)
CSI Score: 4.8 - Cell Name: epithelial cell (CL0000066)
CSI Score: 4.6 - Cell Name: mural cell (CL0008034)
CSI Score: 4.3 - Cell Name: pericyte (CL0000669)
CSI Score: 4.3 - Cell Name: obsolete animal cell (CL0000548)
CSI Score: 4.2 - Cell Name: retinal ganglion cell (CL0000740)
CSI Score: 4.1 - Cell Name: chondrocyte (CL0000138)
CSI Score: 3.9 - Cell Name: vein endothelial cell (CL0002543)
CSI Score: 3.9 - Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
CSI Score: 3.8 - Cell Name: alveolar macrophage (CL0000583)
CSI Score: 3.7 - Cell Name: hepatic stellate cell (CL0000632)
CSI Score: 3.7 - Cell Name: cardiac endothelial cell (CL0010008)
CSI Score: 3.7 - Cell Name: melanocyte of skin (CL1000458)
CSI Score: 3.5 - Cell Name: mesenchymal stem cell (CL0000134)
CSI Score: 3.4 - Cell Name: fibroblast (CL0000057)
CSI Score: 3.4 - Cell Name: lymphocyte (CL0000542)
CSI Score: 3.4 - Cell Name: malignant cell (CL0001064)
CSI Score: 3.4 - Cell Name: retinal rod cell (CL0000604)
CSI Score: 3.2 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
CSI Score: 3.0 - Cell Name: pulmonary artery endothelial cell (CL1001568)
CSI Score: 3.0 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
CSI Score: 2.9 - Cell Name: cardiac muscle cell (CL0000746)
CSI Score: 2.9 - Cell Name: enteric smooth muscle cell (CL0002504)
CSI Score: 2.9 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
CSI Score: 2.8 - Cell Name: alveolar adventitial fibroblast (CL4028006)
CSI Score: 2.8 - Cell Name: fibroblast of cardiac tissue (CL0002548)
CSI Score: 2.8 - Cell Name: mature T cell (CL0002419)
CSI Score: 2.8 - Cell Name: stromal cell (CL0000499)
CSI Score: 2.6 - Cell Name: glutamatergic neuron (CL0000679)
CSI Score: 2.6 - Cell Name: elicited macrophage (CL0000861)
CSI Score: 2.4 - Cell Name: cardiac neuron (CL0010022)
CSI Score: 2.4 - Cell Name: mesenchymal cell (CL0008019)
CSI Score: 2.4 - Cell Name: neuron (CL0000540)
CSI Score: 2.4 - Cell Name: kidney interstitial fibroblast (CL1000692)
CSI Score: 2.4 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
CSI Score: 2.3 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
CSI Score: 2.3 - Cell Name: glial cell (CL0000125)
CSI Score: 2.2 - Cell Name: bronchus fibroblast of lung (CL2000093)
CSI Score: 2.2 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
CSI Score: 2.1 - Cell Name: cerebral cortex endothelial cell (CL1001602)
CSI Score: 2.0 - Cell Name: T cell (CL0000084)
CSI Score: 2.0 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
CSI Score: 1.9 - Cell Name: mesodermal cell (CL0000222)
CSI Score: 1.9 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
CSI Score: 1.9 - Cell Name: glioblast (CL0000030)
CSI Score: 1.7 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
CSI Score: 1.6 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
CSI Score: 1.6 - Cell Name: melanocyte (CL0000148)
CSI Score: 1.6 - Cell Name: epithelial cell of proximal tubule (CL0002306)
CSI Score: 1.6 - Cell Name: neural progenitor cell (CL0011020)
CSI Score: 1.5 - Cell Name: stratified epithelial cell (CL0000079)
CSI Score: 1.5 - Cell Name: goblet cell (CL0000160)
CSI Score: 1.4 - Cell Name: Mueller cell (CL0000636)
CSI Score: 1.4 - Cell Name: oligodendrocyte (CL0000128)
CSI Score: 1.4 - Cell Name: tendon cell (CL0000388)
CSI Score: 1.4 - Cell Name: conjunctival epithelial cell (CL1000432)
CSI Score: 1.3 - Cell Name: ciliated cell (CL0000064)
CSI Score: 1.3 - Cell Name: blood vessel smooth muscle cell (CL0019018)
CSI Score: 1.3 - Cell Name: basal cell (CL0000646)
CSI Score: 1.3 - Cell Name: Schwann cell (CL0002573)
CSI Score: 1.2 - Cell Name: monocyte (CL0000576)
CSI Score: 1.2 - Cell Name: lung macrophage (CL1001603)
CSI Score: 1.2 - Cell Name: intestinal epithelial cell (CL0002563)
CSI Score: 1.1 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
CSI Score: 1.1 - Cell Name: mature alpha-beta T cell (CL0000791)
CSI Score: 1.1 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
CSI Score: 1.1 - Cell Name: retinal bipolar neuron (CL0000748)
CSI Score: 1.1 - Cell Name: ciliated epithelial cell (CL0000067)
CSI Score: 1.1 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
CSI Score: 0.9 - Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
CSI Score: 0.9
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2501749604
Symbol: A2MG_HUMAN
Name: Alpha-2-macroglobulin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2581245
Title: Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.
PubMed ID: 2581245
PubMed ID: 15611997
Title: Alpha(2) macroglobulin, a PSA-binding protein, is expressed in human prostate stroma.
PubMed ID: 15611997
DOI: 10.1002/pros.20183
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1374237
Title: Structure of the human alpha-2 macroglobulin gene and its promotor.
PubMed ID: 1374237
PubMed ID: 6203908
Title: Primary structure of human alpha 2-macroglobulin. V. The complete structure.
PubMed ID: 6203908
PubMed ID: 2430963
Title: Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.
PubMed ID: 2430963
PubMed ID: 1692292
Title: A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.
PubMed ID: 1692292
PubMed ID: 1370808
Title: Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.
PubMed ID: 1370808
DOI: 10.1007/bf00197266
PubMed ID: 2408344
Title: Human alpha 2-macroglobulin gene is located on chromosome 12.
PubMed ID: 2408344
DOI: 10.1007/bf01534685
PubMed ID: 6167263
Title: Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.
PubMed ID: 6167263
PubMed ID: 6165619
Title: Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.
PubMed ID: 6165619
PubMed ID: 6172288
Title: Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.
PubMed ID: 6172288
PubMed ID: 6195065
Title: Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.
PubMed ID: 6195065
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 9865955
Title: Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin.
PubMed ID: 9865955
PubMed ID: 17608619
Title: Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
PubMed ID: 17608619
DOI: 10.1042/bj20070764
PubMed ID: 1707161
Title: Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene.
PubMed ID: 1707161
Sequence Information:
- Length: 1474
- Mass: 163291
- Checksum: 0A46DF09EFD3CF40
- Sequence:
MGKNKLLHPS LVLLLLVLLP TDASVSGKPQ YMVLVPSLLH TETTEKGCVL LSYLNETVTV SASLESVRGN RSLFTDLEAE NDVLHCVAFA VPKSSSNEEV MFLTVQVKGP TQEFKKRTTV MVKNEDSLVF VQTDKSIYKP GQTVKFRVVS MDENFHPLNE LIPLVYIQDP KGNRIAQWQS FQLEGGLKQF SFPLSSEPFQ GSYKVVVQKK SGGRTEHPFT VEEFVLPKFE VQVTVPKIIT ILEEEMNVSV CGLYTYGKPV PGHVTVSICR KYSDASDCHG EDSQAFCEKF SGQLNSHGCF YQQVKTKVFQ LKRKEYEMKL HTEAQIQEEG TVVELTGRQS SEITRTITKL SFVKVDSHFR QGIPFFGQVR LVDGKGVPIP NKVIFIRGNE ANYYSNATTD EHGLVQFSIN TTNVMGTSLT VRVNYKDRSP CYGYQWVSEE HEEAHHTAYL VFSPSKSFVH LEPMSHELPC GHTQTVQAHY ILNGGTLLGL KKLSFYYLIM AKGGIVRTGT HGLLVKQEDM KGHFSISIPV KSDIAPVARL LIYAVLPTGD VIGDSAKYDV ENCLANKVDL SFSPSQSLPA SHAHLRVTAA PQSVCALRAV DQSVLLMKPD AELSASSVYN LLPEKDLTGF PGPLNDQDNE DCINRHNVYI NGITYTPVSS TNEKDMYSFL EDMGLKAFTN SKIRKPKMCP QLQQYEMHGP EGLRVGFYES DVMGRGHARL VHVEEPHTET VRKYFPETWI WDLVVVNSAG VAEVGVTVPD TITEWKAGAF CLSEDAGLGI SSTASLRAFQ PFFVELTMPY SVIRGEAFTL KATVLNYLPK CIRVSVQLEA SPAFLAVPVE KEQAPHCICA NGRQTVSWAV TPKSLGNVNF TVSAEALESQ ELCGTEVPSV PEHGRKDTVI KPLLVEPEGL EKETTFNSLL CPSGGEVSEE LSLKLPPNVV EESARASVSV LGDILGSAMQ NTQNLLQMPY GCGEQNMVLF APNIYVLDYL NETQQLTPEI KSKAIGYLNT GYQRQLNYKH YDGSYSTFGE RYGRNQGNTW LTAFVLKTFA QARAYIFIDE AHITQALIWL SQRQKDNGCF RSSGSLLNNA IKGGVEDEVT LSAYITIALL EIPLTVTHPV VRNALFCLES AWKTAQEGDH GSHVYTKALL AYAFALAGNQ DKRKEVLKSL NEEAVKKDNS VHWERPQKPK APVGHFYEPQ APSAEVEMTS YVLLAYLTAQ PAPTSEDLTS ATNIVKWITK QQNAQGGFSS TQDTVVALHA LSKYGAATFT RTGKAAQVTI QSSGTFSSKF QVDNNNRLLL QQVSLPELPG EYSMKVTGEG CVYLQTSLKY NILPEKEEFP FALGVQTLPQ TCDEPKAHTS FQISLSVSYT GSRSASNMAI VDVKMVSGFI PLKPTVKMLE RSNHVSRTEV SSNHVLIYLD KVSNQTLSLF FTVLQDVPVR DLKPAIVKVY DYYETDEFAI AEYNAPCSKD LGNA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.