A2M - ENSG00000175899

Details for: A2M

Gene ID: 2

Symbol: A2M

Ensembl ID: ENSG00000175899

Description: alpha-2-macroglobulin

Associated with

Degradation of the extracellular matrix (R-HSA-1474228)
Extracellular matrix organization (R-HSA-1474244)
Formation of fibrin clot (clotting cascade) (R-HSA-140877)
Hdl assembly (R-HSA-8963896)
Hemostasis (R-HSA-109582)
Intrinsic pathway of fibrin clot formation (R-HSA-140837)
Plasma lipoprotein assembly (R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance (R-HSA-174824)
Platelet activation, signaling and aggregation (R-HSA-76002)
Platelet degranulation (R-HSA-114608)
Response to elevated platelet cytosolic ca2+ (R-HSA-76005)
Transport of small molecules (R-HSA-382551)
Acute-phase response (GO:0006953)
Acute inflammatory response to antigenic stimulus (GO:0002438)
Blood microparticle (GO:0072562)
Brain-derived neurotrophic factor binding (GO:0048403)
Calcium-dependent protein binding (GO:0048306)
Collagen-containing extracellular matrix (GO:0062023)
Embryonic liver development (GO:1990402)
Endopeptidase inhibitor activity (GO:0004866)
Enzyme binding (GO:0019899)
Extracellular exosome (GO:0070062)
Extracellular region (GO:0005576)
Extracellular space (GO:0005615)
Growth factor binding (GO:0019838)
Identical protein binding (GO:0042802)
Interleukin-1 binding (GO:0019966)
Interleukin-8 binding (GO:0019959)
Luteinization (GO:0001553)
Negative regulation of complement activation, lectin pathway (GO:0001869)
Nerve growth factor binding (GO:0048406)
Platelet alpha granule lumen (GO:0031093)
Protease binding (GO:0002020)
Protein binding (GO:0005515)
Response to carbon dioxide (GO:0010037)
Response to glucocorticoid (GO:0051384)
Response to nutrient (GO:0007584)
Response to prostaglandin e (GO:0034695)
Serine-type endopeptidase inhibitor activity (GO:0004867)
Signaling receptor binding (GO:0005102)
Stem cell differentiation (GO:0048863)
Tumor necrosis factor binding (GO:0043120)

Cells (max top 100)

Cell Name: hepatoblast (CL0005026)
Fold Change: 6.68
Marker Score: 21868
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 5.58
Marker Score: 3101
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.97
Marker Score: 10081
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.74
Marker Score: 3565
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.51
Marker Score: 3023
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.5
Marker Score: 7680.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.46
Marker Score: 2462
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.27
Marker Score: 1624
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.23
Marker Score: 4693
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.21
Marker Score: 6404
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.06
Marker Score: 8024
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 3
Marker Score: 698
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.89
Marker Score: 1046
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.86
Marker Score: 4134
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.77
Marker Score: 1656
Cell Name: contractile cell (CL0000183)
Fold Change: 2.77
Marker Score: 1499
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.74
Marker Score: 1141
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.6
Marker Score: 3568
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.56
Marker Score: 2411
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.52
Marker Score: 4846
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.48
Marker Score: 2118
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.42
Marker Score: 987
Cell Name: muscle cell (CL0000187)
Fold Change: 2.33
Marker Score: 659
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.3
Marker Score: 2061
Cell Name: supporting cell (CL0000630)
Fold Change: 2.28
Marker Score: 4283
Cell Name: microglial cell (CL0000129)
Fold Change: 2.27
Marker Score: 4138
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.23
Marker Score: 579
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.17
Marker Score: 3681
Cell Name: pericyte (CL0000669)
Fold Change: 2.15
Marker Score: 1253
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.1
Marker Score: 1156
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.1
Marker Score: 594
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 2
Marker Score: 425
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.99
Marker Score: 10680.5
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.93
Marker Score: 799
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.9
Marker Score: 740
Cell Name: osteoblast (CL0000062)
Fold Change: 1.89
Marker Score: 1012
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.84
Marker Score: 1212
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.84
Marker Score: 1837
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.81
Marker Score: 1825
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.81
Marker Score: 1945
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.75
Marker Score: 1584
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.75
Marker Score: 39023
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.74
Marker Score: 785
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.73
Marker Score: 1089
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.72
Marker Score: 505
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.71
Marker Score: 7399
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.71
Marker Score: 644
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.69
Marker Score: 422
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.69
Marker Score: 1808
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.68
Marker Score: 422
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.68
Marker Score: 2093
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.65
Marker Score: 2039
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.63
Marker Score: 392.5
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.63
Marker Score: 356
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.59
Marker Score: 385
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.54
Marker Score: 1771
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.54
Marker Score: 391
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.52
Marker Score: 419.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167522
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.46
Marker Score: 460
Cell Name: fibroblast (CL0000057)
Fold Change: 1.45
Marker Score: 1396
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.41
Marker Score: 9064
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.4
Marker Score: 356
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.39
Marker Score: 3611
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.38
Marker Score: 321
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.38
Marker Score: 4892
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.34
Marker Score: 2541
Cell Name: decidual cell (CL2000002)
Fold Change: 1.32
Marker Score: 5692
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.21
Marker Score: 804
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.19
Marker Score: 314
Cell Name: macrophage (CL0000235)
Fold Change: 1.18
Marker Score: 1309
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.16
Marker Score: 308
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.15
Marker Score: 1316
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.15
Marker Score: 579
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.14
Marker Score: 777
Cell Name: lactocyte (CL0002325)
Fold Change: 1.12
Marker Score: 18048
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.1
Marker Score: 5410.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.05
Marker Score: 1372
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71745
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47970
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30399
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.98
Marker Score: 17340
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.97
Marker Score: 1982
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.97
Marker Score: 218
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.96
Marker Score: 601
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.95
Marker Score: 2983
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.93
Marker Score: 263
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.93
Marker Score: 425
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2732
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4961
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.86
Marker Score: 655
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.85
Marker Score: 323
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.83
Marker Score: 1004
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.81
Marker Score: 12659.5
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.8
Marker Score: 970
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.79
Marker Score: 322
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1250
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.77
Marker Score: 437

# Summary The A2M gene encodes a protein called alpha-2-macroglobulin (A2M). A2M is a secreted protein that plays a critical role in the regulation of blood clot formation and inflammation. It is expressed in a variety of cell types, including hepatoblasts, endothelial cells, pericytes, and macrophages. # Key characteristics * A2M is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a member of the immunoglobulin superfamily. * A2M is produced by a variety of cell types in response to injury or inflammation. * It is a key regulator of the coagulation cascade, which is responsible for the formation of blood clots. * A2M also plays a role in the regulation of inflammation and cell migration. # Pathways and functions * A2M is produced in response to injury or inflammation. * It binds to collagen and elastin fibers in the extracellular matrix, which is a protein that provides structural support for blood vessels. * This binding prevents the formation of new blood clots and helps to stabilize existing clots. * A2M also binds to platelets, which are small blood cells that play a key role in blood clotting. * This binding activates platelets and promotes the formation of blood clots. * A2M is also involved in the regulation of inflammation. * It can inhibit the activity of serine-type endopeptidases, which are enzymes that break down proteins. * This inhibition helps to prevent the degradation of A2M and other proteins that are involved in blood clot formation. # Clinical significance A2M is a clinically significant protein in patients with cardiovascular disease. In people with cardiovascular disease, high levels of A2M have been linked to increased risk of thrombosis. This is because A2M can promote the formation of blood clots, which can lead to heart attack and stroke. A2M can be measured in the blood to assess the risk of cardiovascular disease. High levels of A2M have been shown to be associated with an increased risk of cardiovascular events. A2M can be a target for therapy in patients with cardiovascular disease. There are a number of drugs that can block the activity of A2M, which can help to prevent the formation of blood clots and reduce the risk of cardiovascular events.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.