Genular: Defining Cellular Identity and Function

Details for: Polr1b

Gene ID: 20017

Symbol: Polr1b

Ensembl ID: ENSMUSG00000027395

Description: polymerase (RNA) I polypeptide B

Associated with

B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Epigenetic regulation of gene expression
(R-MMU-212165)
Gene expression (transcription)
(R-MMU-74160)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i promoter escape
(R-MMU-73772)
Rna polymerase i transcription
(R-MMU-73864)
Rna polymerase i transcription initiation
(R-MMU-73762)
Rna polymerase i transcription termination
(R-MMU-73863)
Chromosome
(GO:0005694)
Cytosol
(GO:0005829)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna-directed rna polymerase complex
(GO:0000428)
Dna-templated transcription
(GO:0006351)
Dna/rna hybrid binding
(GO:0071667)
Dna binding
(GO:0003677)
Embryo development
(GO:0009790)
Embryo implantation
(GO:0007566)
Fibrillar center
(GO:0001650)
Metal ion binding
(GO:0046872)
Nucleologenesis
(GO:0017126)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotidyltransferase activity
(GO:0016779)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Ribonucleoside binding
(GO:0032549)
Rna polymerase i activity
(GO:0001054)
Rna polymerase i complex
(GO:0005736)
Rrna transcription
(GO:0009303)
Transferase activity
(GO:0016740)

Other Information

Proteins

DNA-directed RNA polymerase I subunit RPA2

Genular Protein ID: 1631178212

Symbol: RPA2_MOUSE

Name: DNA-directed RNA polymerase I subunit RPA2

UniProtKB Accession Codes:

P70700 Q3UMX7

Database IDs:

Citations:

PubMed ID: 8921381

Title: Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I.

PubMed ID: 8921381

DOI: 10.1006/geno.1996.0531

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30272023

Title: Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis.

PubMed ID: 30272023

DOI: 10.1038/s42003-018-0154-z

PubMed ID: 30949703

Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.

PubMed ID: 30949703

DOI: 10.1093/nar/gkz226

PubMed ID: 30746471

Title: SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I.

PubMed ID: 30746471

DOI: 10.1126/sciadv.aau9780

Sequence Information:

Length: 1135
Mass: 128213
Checksum: AF0E1BE0A98116E6
Sequence:

MDVDGRWRNL PSGPSLKHLT DPSYGIPPEQ QKAALQDLTR AHVDSFNYAA LEGLSHAVQA 
IPPFEFAFKD ERISLTIVDA VISPPSVPKG TICKDLNVYP AECRGRKSTY RGRLTADISW 
AVNGVPKGII KQFLGYVPIM VKSKLCNLYN LPPRVLIEHH EEAEEMGGYF IINGIEKVIR 
MLIVPRRNFP IAMVRPKWKS RGLGYTQFGV SMRCVREEHS AVNMNLHYVE NGTVMLNFIY 
RKELFFLPLG FALKALVSFS DYQIFQELIK GKEEDSFFRN SVSQMLRIVI EEGCHSQKQV 
LNYLGECFRV KLSLPDWYPN VEAAEFLLNQ CICIHLQSNT DKFYLLCLMT RKLFALARGE 
CMDDNPDSLV NQEVLSPGQL FLMFLKEKME NWLVSIKIVL DKRAQKANVS INNENLMKIF 
SMGTELTRPF EYLLATGNLR SKTGLGFLQD SGLCVVADKL NFLRYLSHFR CVHRGAAFAK 
MRTTTVRRLL PESWGFLCPV HTPDGAPCGL LNHLTAVCEV VTKFVYTASI PALLCGLGVT 
PVDTAPCRPY SDCYPVLLDG VMVGWVDKDL APEVADTLRR FKVLREKRIP PWMEVALIPM 
TGKPSLYPGL FLFTTPCRLV RPVQNLELGR EELIGTMEQL FMNVAIFEDE VFGGISTHQE 
LFPHSLLSVI ANFIPFSDHN QSPRNMYQCQ MGKQTMGFPL LTYQNRSDNK LYRLQTPQSP 
LVRPCMYDFY DMDNYPIGTN AIVAVISYTG YDMEDAMIVN KASWERGFAH GSVYKSEFID 
LSEKFKQGED NLVFGVKPGD PRVMQKLDDD GLPFIGAKLE YGDPYYSYLN LNTGEGFVVY 
YKSKENCVVD NIKVCSNDMG SGKFKCICIT VRIPRNPTIG DKFASRHGQK GILSRLWPAE 
DMPFTESGMM PDILFNPHGF PSRMTIGMLI ESMAGKSAAL HGLCHDATPF IFSEENSALE 
YFGEMLKAAG YNFYGTERLY SGISGMELEA DIFIGVVYYQ RLRHMVSDKF QVRTTGARDK 
VTNQPLGGRN VQGGIRFGEM ERDALLAHGT SFLLHDRLFN CSDRSVAHMC VECGSLLSPL 
LEKPPPSWSA MRNRKYNCTV CGRSDTIDTV SVPYVFRYFV AELAAMNIKV KLDVI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Polr1b

Associated with

Other Information

Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I. PubMed ID: 8921381

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. PubMed ID: 30272023

SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. PubMed ID: 30949703

SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. PubMed ID: 30746471