Genular: Defining Cellular Identity and Function

Details for: Polr2a

Gene ID: 20020

Symbol: Polr2a

Ensembl ID: ENSMUSG00000005198

Description: polymerase (RNA) II (DNA directed) polypeptide A

Associated with

Dna repair
(R-MMU-73894)
Dual incision in tc-ner
(R-MMU-6782135)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Fgfr2 alternative splicing
(R-MMU-6803529)
Formation of rna pol ii elongation complex
(R-MMU-112382)
Formation of tc-ner pre-incision complex
(R-MMU-6781823)
Formation of the early elongation complex
(R-MMU-113418)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-MMU-6782210)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of rna
(R-MMU-8953854)
Mrna capping
(R-MMU-72086)
Mrna splicing
(R-MMU-72172)
Mrna splicing - major pathway
(R-MMU-72163)
Mrna splicing - minor pathway
(R-MMU-72165)
Nucleotide excision repair
(R-MMU-5696398)
Processing of capped intron-containing pre-mrna
(R-MMU-72203)
Rna pol ii ctd phosphorylation and interaction with ce
(R-MMU-77075)
Rna polymerase ii pre-transcription events
(R-MMU-674695)
Rna polymerase ii promoter escape
(R-MMU-73776)
Rna polymerase ii transcribes snrna genes
(R-MMU-6807505)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase ii transcription elongation
(R-MMU-75955)
Rna polymerase ii transcription initiation
(R-MMU-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-MMU-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-MMU-73779)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Tp53 regulates transcription of dna repair genes
(R-MMU-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
Transcriptional regulation by tp53
(R-MMU-3700989)
Chromosome
(GO:0005694)
Core promoter sequence-specific dna binding
(GO:0001046)
Cytoplasm
(GO:0005737)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Dna-directed rna polymerase complex
(GO:0000428)
Dna-templated transcription
(GO:0006351)
Dna-templated transcription termination
(GO:0006353)
Dna binding
(GO:0003677)
Euchromatin
(GO:0000791)
Kinase binding
(GO:0019900)
Metal ion binding
(GO:0046872)
Microfibril binding
(GO:0050436)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotidyltransferase activity
(GO:0016779)
Nucleus
(GO:0005634)
Positive regulation of rna splicing
(GO:0033120)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Prp19 complex
(GO:0000974)
Rna polymerase ii, core complex
(GO:0005665)
Rna polymerase ii activity
(GO:0001055)
Transcription by rna polymerase ii
(GO:0006366)
Transferase activity
(GO:0016740)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

DNA-directed RNA polymerase II subunit RPB1

Genular Protein ID: 435533166

Symbol: RPB1_MOUSE

Name: DNA-directed RNA polymerase II subunit RPB1

UniProtKB Accession Codes:

P08775 Q5F298

Database IDs:

Citations:

PubMed ID: 3038894

Title: Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II.

PubMed ID: 3038894

DOI: 10.1016/s0021-9258(18)61020-8

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 2999785

Title: A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.

PubMed ID: 2999785

DOI: 10.1073/pnas.82.23.7934

PubMed ID: 1542581

Title: Complete sequence of the human RNA polymerase II largest subunit.

PubMed ID: 1542581

DOI: 10.1093/nar/20.4.910

PubMed ID: 8692929

Title: The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins.

PubMed ID: 8692929

DOI: 10.1073/pnas.93.14.6975

PubMed ID: 11030652

Title: A myosin I isoform in the nucleus.

PubMed ID: 11030652

DOI: 10.1126/science.290.5490.337

PubMed ID: 17526739

Title: Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells.

PubMed ID: 17526739

DOI: 10.1128/mcb.01667-06

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19141475

Title: The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

PubMed ID: 19141475

DOI: 10.1101/gad.1720008

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22767893

Title: Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.

PubMed ID: 22767893

DOI: 10.1126/science.1221592

PubMed ID: 24207025

Title: Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.

PubMed ID: 24207025

DOI: 10.1016/j.molcel.2013.10.009

PubMed ID: 26687004

Title: Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells.

PubMed ID: 26687004

DOI: 10.7554/elife.11215

PubMed ID: 32142649

Title: Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.

PubMed ID: 32142649

DOI: 10.1016/j.cell.2020.02.010

Sequence Information:

Length: 1970
Mass: 217176
Checksum: 7D76F38FD92A657E
Sequence:

MHGGGPPSGD SACPLRTIKR VQFGVLSPDE LKRMSVTEGG IKYPETTEGG RPKLGGLMDP 
RQGVIERTGR CQTCAGNMTE CPGHFGHIEL AKPVFHVGFL VKTMKVLRCV CFFCSKLLVD 
SNNPKIKDIL AKSKGQPKKR LTHVYDLCKG KNICEGGEEM DNKFGVEQPE GDEDLTKEKG 
HGGCGRYQPR IRRSGLELYA EWKHVNEDSQ EKKILLSPER VHEIFKRISD EECFVLGMEP 
RYARPEWMIV TVLPVPPLSV RPAVVMQGSA RNQDDLTHKL ADIVKINNQL RRNEQNGAAA 
HVIAEDVKLL QFHVATMVDN ELPGLPRAMQ KSGRPLKSLK QRLKGKEGRV RGNLMGKRVD 
FSARTVITPD PNLSIDQVGV PRSIAANMTF AEIVTPFNID RLQELVRRGN SQYPGAKYII 
RDNGDRIDLR FHPKPSDLHL QTGYKVERHM CDGDIVIFNR QPTLHKMSMM GHRVRILPWS 
TFRLNLSVTT PYNADFDGDE MNLHLPQSLE TRAEIQELAM VPRMIVTPQS NRPVMGIVQD 
TLTAVRKFTK RDVFLERGEV MNLLMFLSTW DGKVPQPAIL KPRPLWTGKQ IFSLIIPGHI 
NCIRTHSTHP DDEDSGPYKH ISPGDTKVVV ENGELIMGIL CKKSLGTSAG SLVHISYLEM 
GHDITRLFYS NIQTVINNWL LIEGHTIGIG DSIADSKTYQ DIQNTIKKAK QDVIEVIEKA 
HNNELEPTPG NTLRQTFENQ VNRILNDARD KTGSSAQKSL SEYNNFKSMV VSGAKGSKIN 
ISQVIAVVGQ QNVEGKRIPF GFKHRTLPHF IKDDYGPESR GFVENSYLAG LTPTEFFFHA 
MGGREGLIDT AVKTAETGYI QRRLIKSMES VMVKYDATVR NSINQVVQLR YGEDGLAGES 
VEFQNLATLK PSNKAFEKKF RFDYTNERAL RRTLQEDLVK DVLSNAHIQN ELEREFERMR 
EDREVLRVIF PTGDSKVVLP CNLLRMIWNA QKIFHINPRL PSDLHPIKVV EGVKELSKKL 
VIVNGDDPLS RQAQENATLL FNIHLRSTLC SRRMAEEFRL SGEAFDWLLG EIESKFNQAI 
AHPGEMVGAL AAQSLGEPAT QMTLNTFHYA GVSAKNVTLG VPRLKELINI SKKPKTPSLT 
VFLLGQSARD AERAKDILCR LEHTTLRKVT ANTAIYYDPN PQSTVVAEDQ EWVNVYYEMP 
DFDVARISPW LLRVELDRKH MTDRKLTMEQ IAEKINAGFG DDLNCIFNDD NAEKLVLRIR 
IMNSDENKMQ EEEEVVDKMD DDVFLRCIES NMLTDMTLQG IEQISKVYMH LPQTDNKKKI 
IITEDGEFKA LQEWILETDG VSLMRVLSEK DVDPVRTTSN DIVEIFTVLG IEAVRKALER 
ELYHVISFDG SYVNYRHLAL LCDTMTCRGH LMAITRHGVN RQDTGPLMKC SFEETVDVLM 
EAAAHGESDP MKGVSENIML GQLAPAGTGC FDLLLDAEKC KYGMEIPTNI PGLGAAGPTG 
MFFGSAPSPM GGISPAMTPW NQGATPAYGA WSPSVGSGMT PGAAGFSPSA ASDASGFSPG 
YSPAWSPTPG SPGSPGPSSP YIPSPGGAMS PSYSPTSPAY EPRSPGGYTP QSPSYSPTSP 
SYSPTSPSYS PTSPNYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP 
TSPSYSPTSP SYSPTSPSYS PTSPSYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS 
YSPTSPNYSP TSPNYTPTSP SYSPTSPSYS PTSPNYTPTS PNYSPTSPSY SPTSPSYSPT 
SPSYSPSSPR YTPQSPTYTP SSPSYSPSSP SYSPTSPKYT PTSPSYSPSS PEYTPASPKY 
SPTSPKYSPT SPKYSPTSPT YSPTTPKYSP TSPTYSPTSP VYTPTSPKYS PTSPTYSPTS 
PKYSPTSPTY SPTSPKGSTY SPTSPGYSPT SPTYSLTSPA ISPDDSDEEN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Polr2a

Associated with

Other Information

Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II. PubMed ID: 3038894

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II. PubMed ID: 2999785

Complete sequence of the human RNA polymerase II largest subunit. PubMed ID: 1542581

The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. PubMed ID: 8692929

A myosin I isoform in the nucleus. PubMed ID: 11030652

Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. PubMed ID: 17526739

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. PubMed ID: 19141475

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. PubMed ID: 22767893

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. PubMed ID: 24207025

Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells. PubMed ID: 26687004

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair. PubMed ID: 32142649