Genular: Defining Cellular Identity and Function

Details for: Rps6

Gene ID: 20104

Symbol: Rps6

Ensembl ID: ENSMUSG00000028495

Description: ribosomal protein S6

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-MMU-72662)
Cap-dependent translation initiation
(R-MMU-72737)
Eukaryotic translation initiation
(R-MMU-72613)
Formation of a pool of free 40s subunits
(R-MMU-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-MMU-72695)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-MMU-163841)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-MMU-72706)
L13a-mediated translational silencing of ceruloplasmin expression
(R-MMU-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-MMU-6791226)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Mtorc1-mediated signalling
(R-MMU-166208)
Mtor signalling
(R-MMU-165159)
Nonsense-mediated decay (nmd)
(R-MMU-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-MMU-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-MMU-975956)
Post-translational protein modification
(R-MMU-597592)
Protein hydroxylation
(R-MMU-9629569)
Ribosomal scanning and start codon recognition
(R-MMU-72702)
Rrna processing in the nucleus and cytosol
(R-MMU-8868773)
Signal transduction
(R-MMU-162582)
Srp-dependent cotranslational protein targeting to membrane
(R-MMU-1799339)
Translation initiation complex formation
(R-MMU-72649)
Activation-induced cell death of t cells
(GO:0006924)
Cell body
(GO:0044297)
Cellular response to ethanol
(GO:0071361)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Erythrocyte development
(GO:0048821)
G1/s transition of mitotic cell cycle
(GO:0000082)
Gaba-ergic synapse
(GO:0098982)
Gastrulation
(GO:0007369)
Glucose homeostasis
(GO:0042593)
Mammalian oogenesis stage
(GO:0022605)
Mitotic cell cycle
(GO:0000278)
Mitotic cell cycle checkpoint signaling
(GO:0007093)
Mrna binding
(GO:0003729)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bicellular tight junction assembly
(GO:1903347)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Placenta development
(GO:0001890)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Response to insulin
(GO:0032868)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rrna processing
(GO:0006364)
Small-subunit processome
(GO:0032040)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
T cell differentiation in thymus
(GO:0033077)
T cell proliferation involved in immune response
(GO:0002309)
Tor signaling
(GO:0031929)
Translation
(GO:0006412)

Other Information

Proteins

40S ribosomal protein S6

Genular Protein ID: 3470720377

Symbol: RS6_MOUSE

Name: 40S ribosomal protein S6

UniProtKB Accession Codes:

P62754 P08227 P10660

Database IDs:

Citations:

PubMed ID: 3601662

Title: Complete sequence of mouse S6 ribosomal protein.

PubMed ID: 3601662

DOI: 10.1093/nar/15.12.4990

PubMed ID: 8917105

Title: Structural characterization of the mouse ribosomal protein S6-encoding gene.

PubMed ID: 8917105

DOI: 10.1016/0378-1119(96)00157-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1939282

Title: Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites.

PubMed ID: 1939282

DOI: 10.1016/s0021-9258(18)54634-2

PubMed ID: 8440735

Title: Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.

PubMed ID: 8440735

DOI: 10.1016/s0021-9258(18)53642-5

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 36517592

Title: A male germ-cell-specific ribosome controls male fertility.

PubMed ID: 36517592

DOI: 10.1038/s41586-022-05508-0

Sequence Information:

Length: 249
Mass: 28681
Checksum: A61E435884E636AE
Sequence:

MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG 
FPMKQGVLTH GRVRLLLSKG HSCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD 
IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK PLNKEGKKPR TKAPKIQRLV 
TPRVLQHKRR RIALKKQRTK KNKEEAAEYA KLLAKRMKEA KEKRQEQIAK RRRLSSLRAS 
TSKSESSQK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rps6

Associated with

Other Information

Complete sequence of mouse S6 ribosomal protein. PubMed ID: 3601662

Structural characterization of the mouse ribosomal protein S6-encoding gene. PubMed ID: 8917105

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. PubMed ID: 1939282

Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum. PubMed ID: 8440735

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

A male germ-cell-specific ribosome controls male fertility. PubMed ID: 36517592