Genular: Defining Cellular Identity and Function

Details for: Rrm2

Gene ID: 20135

Symbol: Rrm2

Ensembl ID: ENSMUSG00000020649

Description: ribonucleotide reductase M2

Associated with

Interconversion of nucleotide di- and triphosphates
(R-MMU-499943)
Metabolism
(R-MMU-1430728)
Metabolism of nucleotides
(R-MMU-15869)
2'-deoxyribonucleotide biosynthetic process
(GO:0009265)
Blastocyst development
(GO:0001824)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Deoxyribonucleotide biosynthetic process
(GO:0009263)
Deoxyribonucleotide metabolic process
(GO:0009262)
Ferric iron binding
(GO:0008199)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Nuclear envelope
(GO:0005635)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Protein binding
(GO:0005515)
Protein heterotetramerization
(GO:0051290)
Protein homodimerization activity
(GO:0042803)
Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
(GO:0004748)
Ribonucleoside-diphosphate reductase complex
(GO:0005971)
Ribonucleoside diphosphate metabolic process
(GO:0009185)

Other Information

Proteins

Ribonucleoside-diphosphate reductase subunit M2

Genular Protein ID: 1080473133

Symbol: RIR2_MOUSE

Name: Ribonucleoside-diphosphate reductase subunit M2

UniProtKB Accession Codes:

P11157 Q3UI23 Q542E2

Database IDs:

Citations:

PubMed ID: 3025593

Title: Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase.

PubMed ID: 3025593

DOI: 10.1128/mcb.6.10.3433-3442.1986

PubMed ID: 2684652

Title: Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new dominant marker gene.

PubMed ID: 2684652

DOI: 10.1002/j.1460-2075.1989.tb08383.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 8876648

Title: The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.

PubMed ID: 8876648

DOI: 10.1006/jmbi.1996.0546

PubMed ID: 12087093

Title: Cobalt substitution of mouse R2 ribonucleotide reductase as a model for the reactive diferrous state. Spectroscopic and structural evidence for a ferromagnetically coupled dinuclear cobalt cluster.

PubMed ID: 12087093

DOI: 10.1074/jbc.m203358200

PubMed ID: 7583667

Title: NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.

PubMed ID: 7583667

DOI: 10.1038/nsb1195-951

Sequence Information:

Length: 390
Mass: 45096
Checksum: AC7ACC4FAF8A4A2F
Sequence:

MLSVRTPLAT IADQQQLQLS PLKRLTLADK ENTPPTLSST RVLASKAARR IFQDSAELES 
KAPTNPSVED EPLLRENPRR FVVFPIEYHD IWQMYKKAEA SFWTAEEVDL SKDIQHWEAL 
KPDERHFISH VLAFFAASDG IVNENLVERF SQEVQVTEAR CFYGFQIAME NIHSEMYSLL 
IDTYIKDPKE REYLFNAIET MPCVKKKADW ALRWIGDKEA TYGERVVAFA AVEGIFFSGS 
FASIFWLKKR GLMPGLTFSN ELISRDEGLH CDFACLMFKH LVHKPAEQRV REIITNAVRI 
EQEFLTEALP VKLIGMNCTL MKQYIEFVAD RLMLELGFNK IFRVENPFDF MENISLEGKT 
NFFEKRVGEY QRMGVMSNST ENSFTLDADF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rrm2

Associated with

Other Information

Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase. PubMed ID: 3025593

Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new dominant marker gene. PubMed ID: 2684652

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2. PubMed ID: 8876648

Cobalt substitution of mouse R2 ribonucleotide reductase as a model for the reactive diferrous state. Spectroscopic and structural evidence for a ferromagnetically coupled dinuclear cobalt cluster. PubMed ID: 12087093

NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit. PubMed ID: 7583667