Details for: Nr1h4

Gene ID: 20186

Symbol: Nr1h4

Ensembl ID: ENSMUSG00000047638

Description: nuclear receptor subfamily 1, group H, member 4

Associated with

  • Bile acid and bile salt metabolism
    (R-MMU-194068)
  • Biological oxidations
    (R-MMU-211859)
  • Cytochrome p450 - arranged by substrate type
    (R-MMU-211897)
  • Endogenous sterols
    (R-MMU-211976)
  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Metabolism
    (R-MMU-1430728)
  • Metabolism of lipids
    (R-MMU-556833)
  • Metabolism of proteins
    (R-MMU-392499)
  • Metabolism of steroids
    (R-MMU-8957322)
  • Nuclear receptor transcription pathway
    (R-MMU-383280)
  • Phase i - functionalization of compounds
    (R-MMU-211945)
  • Post-translational protein modification
    (R-MMU-597592)
  • Recycling of bile acids and salts
    (R-MMU-159418)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Sumo e3 ligases sumoylate target proteins
    (R-MMU-3108232)
  • Sumoylation
    (R-MMU-2990846)
  • Sumoylation of intracellular receptors
    (R-MMU-4090294)
  • Synthesis of bile acids and bile salts
    (R-MMU-192105)
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
    (R-MMU-193368)
  • Synthesis of bile acids and bile salts via 27-hydroxycholesterol
    (R-MMU-193807)
  • Bile acid and bile salt transport
    (GO:0015721)
  • Bile acid binding
    (GO:0032052)
  • Bile acid metabolic process
    (GO:0008206)
  • Bile acid receptor activity
    (GO:0038181)
  • Bile acid signaling pathway
    (GO:0038183)
  • Cell-cell junction assembly
    (GO:0007043)
  • Cell differentiation
    (GO:0030154)
  • Chenodeoxycholic acid binding
    (GO:1902122)
  • Cholesterol homeostasis
    (GO:0042632)
  • Defense response to bacterium
    (GO:0042742)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Glucose homeostasis
    (GO:0042593)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Intracellular bile acid receptor signaling pathway
    (GO:0038185)
  • Intracellular glucose homeostasis
    (GO:0001678)
  • Intracellular receptor signaling pathway
    (GO:0030522)
  • Intracellular triglyceride homeostasis
    (GO:0035356)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of collagen biosynthetic process
    (GO:0032966)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of triglyceride biosynthetic process
    (GO:0010868)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of very-low-density lipoprotein particle remodeling
    (GO:0010903)
  • Nitrogen catabolite activation of transcription from rna polymerase ii promoter
    (GO:0001080)
  • Notch signaling pathway
    (GO:0007219)
  • Nuclear receptor activity
    (GO:0004879)
  • Nuclear retinoid x receptor binding
    (GO:0046965)
  • Peptide binding
    (GO:0042277)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Regulation of carbohydrate metabolic process
    (GO:0006109)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of low-density lipoprotein particle clearance
    (GO:0010988)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of urea metabolic process
    (GO:0034255)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Toll-like receptor 9 signaling pathway
    (GO:0034162)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coregulator binding
    (GO:0001221)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 250969361

Symbol: NR1H4_MOUSE

Name: Bile acid receptor

UniProtKB Accession Codes:

Q60641 D3YTT2 E9QJW2 Q60642 Q60643

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 DIP 1 DNASU 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 78 Gene3D 2 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 3 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 7 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7760852

Title: Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.

PubMed ID: 7760852

DOI: 10.1210/mend.9.1.7760852

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11030617

Title: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

PubMed ID: 11030617

DOI: 10.1016/s0092-8674(00)00062-3

PubMed ID: 11579204

Title: Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.

PubMed ID: 11579204

DOI: 10.1210/mend.15.10.0712

PubMed ID: 12004058

Title: The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.

PubMed ID: 12004058

DOI: 10.1074/jbc.m200824200

PubMed ID: 11706036

Title: Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

PubMed ID: 11706036

DOI: 10.1074/jbc.m109326200

PubMed ID: 12891557

Title: Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

PubMed ID: 12891557

DOI: 10.1016/s0016-5085(03)00896-5

PubMed ID: 12393883

Title: Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation.

PubMed ID: 12393883

DOI: 10.1074/jbc.m209505200

PubMed ID: 12421815

Title: The farnesoid X-receptor is an essential regulator of cholesterol homeostasis.

PubMed ID: 12421815

DOI: 10.1074/jbc.m209525200

PubMed ID: 12660231

Title: Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor.

PubMed ID: 12660231

DOI: 10.1074/jbc.m302505200

PubMed ID: 14729567

Title: Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR.

PubMed ID: 14729567

DOI: 10.1101/gad.1138104

PubMed ID: 15146238

Title: Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.

PubMed ID: 15146238

DOI: 10.1172/jci21025

PubMed ID: 16213224

Title: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

PubMed ID: 16213224

DOI: 10.1016/j.cmet.2005.09.001

PubMed ID: 15564327

Title: Regulation of carbohydrate metabolism by the farnesoid X receptor.

PubMed ID: 15564327

DOI: 10.1210/en.2004-0965

PubMed ID: 16946559

Title: Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.

PubMed ID: 16946559

DOI: 10.2133/dmpk.21.315

PubMed ID: 16446356

Title: The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.

PubMed ID: 16446356

DOI: 10.1074/jbc.m510258200

PubMed ID: 16557297

Title: Farnesoid X receptor is essential for normal glucose homeostasis.

PubMed ID: 16557297

DOI: 10.1172/jci25604

PubMed ID: 16410358

Title: Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.

PubMed ID: 16410358

DOI: 10.1073/pnas.0506982103

PubMed ID: 16473946

Title: Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.

PubMed ID: 16473946

DOI: 10.1073/pnas.0509592103

PubMed ID: 19047134

Title: Nuclear bile acid receptor FXR protects against intestinal tumorigenesis.

PubMed ID: 19047134

DOI: 10.1158/0008-5472.can-08-1791

PubMed ID: 18842595

Title: The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.

PubMed ID: 18842595

DOI: 10.1074/jbc.m803531200

PubMed ID: 18972444

Title: Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response.

PubMed ID: 18972444

DOI: 10.1002/hep.22519

PubMed ID: 19393742

Title: Reciprocal regulation of the bile acid-activated receptor FXR and the interferon-gamma-STAT-1 pathway in macrophages.

PubMed ID: 19393742

DOI: 10.1016/j.bbadis.2009.04.004

PubMed ID: 19883617

Title: FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.

PubMed ID: 19883617

DOI: 10.1016/j.cmet.2009.09.009

PubMed ID: 19864602

Title: The bile acid receptor FXR is a modulator of intestinal innate immunity.

PubMed ID: 19864602

DOI: 10.4049/jimmunol.0803978

PubMed ID: 19805516

Title: Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.

PubMed ID: 19805516

DOI: 10.1128/mcb.00825-09

PubMed ID: 20447400

Title: The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.

PubMed ID: 20447400

DOI: 10.1016/j.febslet.2010.04.068

PubMed ID: 20091679

Title: Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.

PubMed ID: 20091679

DOI: 10.1002/hep.23450

PubMed ID: 20483916

Title: Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.

PubMed ID: 20483916

DOI: 10.1093/nar/gkq397

PubMed ID: 21383957

Title: Deciphering the nuclear bile acid receptor FXR paradigm.

PubMed ID: 21383957

DOI: 10.1621/nrs.08005

PubMed ID: 21242261

Title: Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.

PubMed ID: 21242261

DOI: 10.1136/gut.2010.212159

PubMed ID: 21804189

Title: Farnesoid X receptor represses hepatic human APOA gene expression.

PubMed ID: 21804189

DOI: 10.1172/jci45277

PubMed ID: 22820415

Title: Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

PubMed ID: 22820415

DOI: 10.1016/j.bbalip.2012.07.004

PubMed ID: 22057115

Title: Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.

PubMed ID: 22057115

DOI: 10.1053/j.gastro.2011.10.028

PubMed ID: 23372731

Title: The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.

PubMed ID: 23372731

DOI: 10.1371/journal.pone.0054472

PubMed ID: 25651182

Title: MAFG is a transcriptional repressor of bile acid synthesis and metabolism.

PubMed ID: 25651182

DOI: 10.1016/j.cmet.2015.01.007

PubMed ID: 25545350

Title: Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.

PubMed ID: 25545350

DOI: 10.1002/hep.27677

PubMed ID: 26505219

Title: FXR primes the liver for intestinal FGF15 signaling by transient induction of beta-Klotho.

PubMed ID: 26505219

DOI: 10.1210/me.2015-1226

Sequence Information:

  • Length: 488
  • Mass: 55994
  • Checksum: 3E59B7146F8ECC86
  • Sequence:
    • MVMQFQGLEN PIQISLHHSH RLSGFVPEGM SVKPAKGMLT EHAAGPLGQN LDLESYSPYN 
NVPFPQVQPQ ISSSSYYSNL GFYPQQPEDW YSPGIYELRR MPAETGYQGE TEVSEMPVTK 
KPRMAAASAG RIKGDELCVV CGDRASGYHY NALTCEGCKG FFRRSITKNA VYKCKNGGNC 
VMDMYMRRKC QECRLRKCKE MGMLAECMYT GLLTEIQCKS KRLRKNVKQH ADQTANEDDS 
EGRDLRQVTS TTKFCREKTE LTADQQTLLD YIMDSYNKQR MPQEITNKIL KEEFSAEENF 
LILTEMATSH VQILVEFTKK LPGFQTLDHE DQIALLKGSA VEAMFLRSAE IFNKKLPAGH 
ADLLEERIRK SGISDEYITP MFSFYKSVGE LKMTQEEYAL LTAIVILSPD RQYIKDREAV 
EKLQEPLLDV LQKLCKMYQP ENPQHFACLL GRLTELRTFN HHHAEMLMSW RVNDHKFTPL 
LCEIWDVQ

Genular Protein ID: 1606371256

Symbol: Q3V1T8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V1T8

Database IDs:

AGR 1 ARBA 9 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 2 Genevisible 1 Google 1 GuidetoPHARMACOLOGY 1 InterPro 7 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 Pfam 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 484
  • Mass: 55542
  • Checksum: 06B56494305A438A
  • Sequence:
    • MVMQFQGLEN PIQISLHHSH RLSGFVPEGM SVKPAKGMLT EHAAGPLGQN LDLESYSPYN 
NVPFPQVQPQ ISSSSYYSNL GFYPQQPEDW YSPGIYELRR MPAETGYQGE TEVSEMPVTK 
KPRMAAASAG RIKGDELCVV CGDRASGYHY NALTCEGCKG FFRRSITKNA VYKCKNGGNC 
VMDMYMRRKC QECRLRKCKE MGMLAECLLT EIQCKSKRLR KNVKQHADQT ANEDDSEGRD 
LRQVTSTTKF CREKTELTAD QQTLLDYIMD SYNKQRMPQE ITNKILKEEF SAEENFLILT 
EMATSHVQIL VEFTKKLPGF QTLDHEDQIA LLKGSAVEAM FLRSAEIFNK KLPAGHADLL 
EERIRKSGIS DEYITPMFSF YKSVGELKMT QEEYALLTAI VILSPDRQYI KDREAVEKLQ 
EPLLDVLQKL CKMYQPENPQ HFACLLGRLT ELRTFNHHHA EMLMSWRVND HKFTPLLCEI 
WDVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.