Details for: CRYBG1

Gene ID: 202

Symbol: CRYBG1

Ensembl ID: ENSG00000112297

Description: crystallin beta-gamma domain containing 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.34
    Marker Score: 3780.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.67
    Marker Score: 2059
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.59
    Marker Score: 2197
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.53
    Marker Score: 2799.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.37
    Marker Score: 6796
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.19
    Marker Score: 1064.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.13
    Marker Score: 1064.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.08
    Marker Score: 2192
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.08
    Marker Score: 3060
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.06
    Marker Score: 8083
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.05
    Marker Score: 634
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.81
    Marker Score: 1608
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.78
    Marker Score: 1237
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.75
    Marker Score: 1173
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.74
    Marker Score: 15039
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.73
    Marker Score: 1051
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.63
    Marker Score: 950.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.62
    Marker Score: 1486
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.57
    Marker Score: 1070
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.57
    Marker Score: 4398
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.54
    Marker Score: 1439
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.53
    Marker Score: 3857
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.51
    Marker Score: 6268.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.5
    Marker Score: 11732
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.49
    Marker Score: 834
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.49
    Marker Score: 300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.46
    Marker Score: 10837
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.39
    Marker Score: 447
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.36
    Marker Score: 13470
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.32
    Marker Score: 1113
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.31
    Marker Score: 3086
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.3
    Marker Score: 1794.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.26
    Marker Score: 1359
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.25
    Marker Score: 883
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.24
    Marker Score: 16517
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.23
    Marker Score: 527
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.22
    Marker Score: 627
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.22
    Marker Score: 369
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.21
    Marker Score: 64094
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.19
    Marker Score: 718
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 979
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.16
    Marker Score: 1646.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.16
    Marker Score: 839
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.15
    Marker Score: 2043
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.11
    Marker Score: 2755.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.08
    Marker Score: 269
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.08
    Marker Score: 3404
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2201
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.08
    Marker Score: 465
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.06
    Marker Score: 5065
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.03
    Marker Score: 606
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1
    Marker Score: 435
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71682
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47904.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.98
    Marker Score: 370
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.98
    Marker Score: 673.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.98
    Marker Score: 1901
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.97
    Marker Score: 54490
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.95
    Marker Score: 186
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.95
    Marker Score: 1022
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.94
    Marker Score: 2313
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.94
    Marker Score: 768
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.93
    Marker Score: 436
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.93
    Marker Score: 268
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.92
    Marker Score: 2188
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.92
    Marker Score: 719
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.91
    Marker Score: 909
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5203
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2704
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.9
    Marker Score: 503
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.9
    Marker Score: 10409
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.89
    Marker Score: 2636
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.89
    Marker Score: 510
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.88
    Marker Score: 937
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.87
    Marker Score: 1001
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.87
    Marker Score: 640
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.86
    Marker Score: 574
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.86
    Marker Score: 31838.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.86
    Marker Score: 435
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.84
    Marker Score: 2665
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1364
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.84
    Marker Score: 2168
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13080
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.83
    Marker Score: 736
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.83
    Marker Score: 1747.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.83
    Marker Score: 778.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 331.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.82
    Marker Score: 258
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.82
    Marker Score: 504
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.82
    Marker Score: 20933
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.82
    Marker Score: 282
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.81
    Marker Score: 401
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.81
    Marker Score: 476

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Other Information

**Key characteristics:** - The gene is located on chromosome 17q21.1. - It is a large gene with a total length of 12.8 kb. - It contains 11 exons and 13 introns. - The protein encoded by the gene is a glycoprotein with a molecular weight of approximately 140 kDa. **Pathways and functions:** - CRBG1 is involved in the regulation of epithelial cell differentiation and function. - It is expressed in the basal epithelial cell of the tracheobronchial tree, renal principal cell, CD8-positive, alpha-beta memory T cell, corneal epithelial cell, retinal cone cell, epicardial adipocyte, DN3 thymocyte, conjunctival epithelial cell, bladder urothelial cell, and placental villous trophoblast. - It is involved in the regulation of epithelial cell migration, proliferation, and differentiation. - It is also involved in the regulation of epithelial cell function, including cell migration, proliferation, and differentiation. **Clinical significance:** - Mutations in the CRBG1 gene have been linked to several human diseases, including Hirschsprung's disease, which is caused by a mutation in the CRBG1 gene. - CRBG1 is a potential therapeutic target for diseases that are caused by mutations in the CRBG1 gene.

Genular Protein ID: 1386070273

Symbol: CRBG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y4K1 B4DU04 O00296 Q5VWJ2

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EPD 1 EvolutionaryTrace 1 GO 1 Gene3D 2 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9096375

Title: AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma.

PubMed ID: 9096375

DOI: 10.1073/pnas.94.7.3229

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18582473

Title: Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-1 (AIM1).

PubMed ID: 18582473

DOI: 10.1016/j.jmb.2008.06.019

Sequence Information:

  • Length: 1723
  • Mass: 188676
  • Checksum: F4137765BCE039D5
  • Sequence:
    • MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS DNASAEKKVK 
SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP ASSPTKRKGR SRALEAVPAP 
PASGPRAPAK ESPPKRVPDP SPVTKGTAAE SGEEAARAIP RELPVKSSSL LPEIKPEHKR 
GPLPNHFNGR AEGGRSRELG RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV 
ELNLKTPKNL DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE EILPATRGMN 
GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK DHKLLEKEDS EAADSKSLVL 
ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT FSDSQSPAES SPGPSLSLSA PAPGDVPKDT 
CVQSPISSFP CTDLKVSENH KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE 
CPSRVLVQVR SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT NSPSSGNHLA 
TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF TEIIKQMDSA VCMPMKRKKA 
RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT FGLGKKKESQ PEMSPALHLM QNLDTKSKLR 
PKRASAEQSV LFKSLHTNTN GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS 
SLPQDKIFSP SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE LSKLKNDDME 
KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG MSLSDTMTLR GSVQNKLNPR 
PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS LSPVILIKVV RGCWILYEQP NFEGHSIPLE 
EGELELSGLW GIEDILERHE EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY 
FDDTEEMQGF GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG 
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE EATGDDHLPF 
TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG GYNGELQSLR PILGDFSNAH 
MIMYSEKNFG SKGSSIDVLG IVANLKETGY GVKTQSINVL SGVWVAYENP DFTGEQYILD 
KGFYTSFEDW GGKNCKISSV QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID 
DSFSTKSCRV SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS 
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY GSYRGRQFLL 
SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF MSTNGNLEDL KLLRIQVMED 
VGADDQIWIY QEGCIKCRIA EDCCLTIVGS LVTSGSKLGL ALDQNADSQF WSLKSDGRIY 
SKLKPNLVLD IKGGTQYDQN HIILNTVSKE KFTQVWEAMV LYT

Genular Protein ID: 4287820662

Symbol: B3KPT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPT0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 926
  • Mass: 98622
  • Checksum: 530ADF1059A214ED
  • Sequence:
    • MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS DNASAEKKVK 
SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP ASSPTKRKGR SRALEAVPAP 
PASGPRAPAK ESPPKRVPDP SPVTKGTAAE SGEEAARAIP RELPVKSSSL LPEIKPEHKR 
GPLPNHFNGR AEGGRSRELG RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV 
ELNLKTPKNL DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE EILPATRGMN 
GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK DHKLLEKEDS EAADSKSLVL 
ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT FSDSQSPAES SPGPSLSLSA PAPGDVPKDT 
CVQSPISSFP CTDLKVSENH KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE 
CPSRVLVQVR SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT NSPSSGNHLA 
TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF TEIIKQMDSA VCMPMKRKKA 
RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT FGLGKKKESQ PEMSPALHLM QNLDTKSKLR 
PKRASAEQSV LFKSLHTNTN GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS 
SLPQDKIFSP SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 
LKVFNFNSSS TSHSSLKSPS HMEKYP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.