Genular: Defining Cellular Identity and Function

Details for: S100a8

Gene ID: 20201

Symbol: S100a8

Ensembl ID: ENSMUSG00000056054

Description: S100 calcium binding protein A8 (calgranulin A)

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metal sequestration by antimicrobial proteins
(R-MMU-6799990)
Neutrophil degranulation
(R-MMU-6798695)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Toll-like receptor cascades
(R-MMU-168898)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Antioxidant activity
(GO:0016209)
Apoptotic process
(GO:0006915)
Astrocyte development
(GO:0014002)
Autocrine signaling
(GO:0035425)
Autophagy
(GO:0006914)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Calprotectin complex
(GO:1990660)
Chemotaxis
(GO:0006935)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Intermediate filament cytoskeleton
(GO:0045111)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Neutrophil aggregation
(GO:0070488)
Neutrophil chemotaxis
(GO:0030593)
Peptide secretion
(GO:0002790)
Peptidyl-cysteine s-nitrosylation
(GO:0018119)
Plasma membrane
(GO:0005886)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of peptide secretion
(GO:0002793)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Response to lipopolysaccharide
(GO:0032496)

Other Information

Proteins

Calgranulin-A

Genular Protein ID: 2464097509

Symbol: S10A8_MOUSE

Name: Calgranulin-A

UniProtKB Accession Codes:

P27005 P31724

Database IDs:

Citations:

PubMed ID: 1373330

Title: Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage.

PubMed ID: 1373330

PubMed ID: 8454868

Title: Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10.

PubMed ID: 8454868

PubMed ID: 8611640

Title: Molecular characterisation of the genomic locus of the mouse MRP8 gene.

PubMed ID: 8611640

DOI: 10.1016/0925-4439(95)00108-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1559987

Title: Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteins.

PubMed ID: 1559987

DOI: 10.1016/s0021-9258(18)42545-8

PubMed ID: 10438963

Title: A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo.

PubMed ID: 10438963

PubMed ID: 17767165

Title: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.

PubMed ID: 17767165

DOI: 10.1038/nm1638

PubMed ID: 18403730

Title: S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products.

PubMed ID: 18403730

DOI: 10.1161/circresaha.107.167544

PubMed ID: 18832721

Title: S-nitrosylated S100A8: novel anti-inflammatory properties.

PubMed ID: 18832721

DOI: 10.4049/jimmunol.181.8.5627

PubMed ID: 20523765

Title: Anti-infective protective properties of S100 calgranulins.

PubMed ID: 20523765

DOI: 10.2174/187152309789838975

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20213444

Title: Inflammation-associated S100 proteins: new mechanisms that regulate function.

PubMed ID: 20213444

DOI: 10.1007/s00726-010-0528-0

PubMed ID: 33388094

Title: Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

PubMed ID: 33388094

DOI: 10.1016/j.chom.2020.12.016

Sequence Information:

Length: 89
Mass: 10295
Checksum: D2AFF46ACE867A28
Sequence:

MPSELEKALS NLIDVYHNYS NIQGNHHALY KNDFKKMVTT ECPQFVQNIN IENLFRELDI 
NSDNAINFEE FLAMVIKVGV ASHKDSHKE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: S100a8

Associated with

Other Information

Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. PubMed ID: 1373330

Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10. PubMed ID: 8454868

Molecular characterisation of the genomic locus of the mouse MRP8 gene. PubMed ID: 8611640

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteins. PubMed ID: 1559987

A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. PubMed ID: 10438963

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. PubMed ID: 17767165

S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. PubMed ID: 18403730

S-nitrosylated S100A8: novel anti-inflammatory properties. PubMed ID: 18832721

Anti-infective protective properties of S100 calgranulins. PubMed ID: 20523765

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Inflammation-associated S100 proteins: new mechanisms that regulate function. PubMed ID: 20213444

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. PubMed ID: 33388094