Genular: Defining Cellular Identity and Function

Details for: Scnn1b

Gene ID: 20277

Symbol: Scnn1b

Ensembl ID: ENSMUSG00000030873

Description: sodium channel, nonvoltage-gated 1 beta

Associated with

Ion channel transport
(R-MMU-983712)
Sensory perception
(R-MMU-9709957)
Stimuli-sensing channels
(R-MMU-2672351)
Transport of small molecules
(R-MMU-382551)
Aldosterone metabolic process
(GO:0032341)
Apical plasma membrane
(GO:0016324)
Artery smooth muscle contraction
(GO:0014824)
Cell surface
(GO:0009986)
Cellular response to acidic ph
(GO:0071468)
Cellular response to aldosterone
(GO:1904045)
Cellular response to vasopressin
(GO:1904117)
Cytoplasmic vesicle
(GO:0031410)
Epithelial fluid transport
(GO:0042045)
Erythrocyte homeostasis
(GO:0034101)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Gene expression
(GO:0010467)
Intracellular sodium ion homeostasis
(GO:0006883)
Leukocyte activation involved in inflammatory response
(GO:0002269)
Ligand-gated sodium channel activity
(GO:0015280)
Membrane
(GO:0016020)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Mucus secretion
(GO:0070254)
Multicellular organismal-level water homeostasis
(GO:0050891)
Multicellular organism growth
(GO:0035264)
Neutrophil-mediated killing of bacterium
(GO:0070944)
Neutrophil activation involved in immune response
(GO:0002283)
Plasma membrane
(GO:0005886)
Potassium ion homeostasis
(GO:0055075)
Protein binding
(GO:0005515)
Regulation of blood pressure
(GO:0008217)
Regulation of sodium ion transport
(GO:0002028)
Renal system process
(GO:0003014)
Response to food
(GO:0032094)
Response to stimulus
(GO:0050896)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of salty taste
(GO:0050914)
Sensory perception of sour taste
(GO:0050915)
Sensory perception of taste
(GO:0050909)
Sodium channel activity
(GO:0005272)
Sodium channel complex
(GO:0034706)
Sodium ion homeostasis
(GO:0055078)
Sodium ion import across plasma membrane
(GO:0098719)
Sodium ion transmembrane transport
(GO:0035725)
Sodium ion transmembrane transporter activity
(GO:0015081)
Sodium ion transport
(GO:0006814)
Wound healing, spreading of epidermal cells
(GO:0035313)
Ww domain binding
(GO:0050699)

Other Information

Proteins

Amiloride-sensitive sodium channel subunit beta

Genular Protein ID: 2394057616

Symbol: SCNNB_MOUSE

Name: Amiloride-sensitive sodium channel subunit beta

UniProtKB Accession Codes:

Q9WU38

Database IDs:

Citations:

PubMed ID: 10409305

Title: Cloning and functional expression of the mouse epithelial sodium channel.

PubMed ID: 10409305

DOI: 10.1152/ajprenal.1999.277.1.f121

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11244092

Title: The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

PubMed ID: 11244092

DOI: 10.1074/jbc.c000906200

PubMed ID: 12424229

Title: The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.

PubMed ID: 12424229

DOI: 10.1096/fj.02-0497fje

PubMed ID: 15123669

Title: Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

PubMed ID: 15123669

DOI: 10.1074/jbc.m402820200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20525693

Title: Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

PubMed ID: 20525693

DOI: 10.1074/jbc.m110.103432

Sequence Information:

Length: 638
Mass: 72197
Checksum: F502A510BFE65392
Sequence:

MPVKKYLLKC LHRLQKGPGY TYKELLVWYC NNTNTHGPKR IICEGPKKKA MWFLLTLLFA 
CLVCWQWGVF IQTYLSWEVS VSLSMGFKTM NFPAVTVCNS SPFQYSKVKH LLKDLDELME 
AVLEKILAPE ASHSNTTRTL NFTIWNHTPL VLIDERNPDH PVVLNLFGDS HNSSNPAPGS 
TCNAQGCKVA MRLCSANGTV CTLRNFTSAT QAVTEWYILQ ATNIFSQVLP QDLVGMGYAP 
DRIILACLFG TEPCSHRNFT PIFYPDYGNC YIFNWGMTEE TLPSANPGTE FGLKLILDIG 
QEDYVPFLAS TAGARLMLHE QRTYPFIREE GIYAMAGTET SIGVLVDKLQ RKGEPYSPCT 
MNGSDVAIKN LYSVYNTTYS IQACLHSCFQ DHMIRNCSCG HYLYPLPEGE KYCNNRDFPD 
WAYCYLNLQM SVTQRETCLS MCKESCNDTQ YKMTISMADW PSEASEDWIL HVLSQERDQS 
SNITLSRKGI VKLNIYFQEF NYRTIEESPA NNIVWLLSNL GGQFGFWMGG SVLCLIEFGE 
IIIDFIWITI IKLVASCKGL RRRRPQAPYT GPPPTVAELV EAHTNFGFQP DTTSCRPHGE 
VYPDQQTLPI PGTPPPNYDS LRLQPLDTME SDSEVEAI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Scnn1b

Associated with

Other Information

Cloning and functional expression of the mouse epithelial sodium channel. PubMed ID: 10409305

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. PubMed ID: 11244092

The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. PubMed ID: 12424229

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. PubMed ID: 15123669

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. PubMed ID: 20525693