Genular: Defining Cellular Identity and Function

Details for: Ccl2

Gene ID: 20296

Symbol: Ccl2

Ensembl ID: ENSMUSG00000035385

Description: C-C motif chemokine ligand 2

Associated with

Angiogenesis
(GO:0001525)
Axon terminus
(GO:0043679)
C-fiber
(GO:0044299)
Ccr2 chemokine receptor binding
(GO:0031727)
Ccr chemokine receptor binding
(GO:0048020)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Dendrite
(GO:0030425)
Endocytic vesicle
(GO:0030139)
Eosinophil chemotaxis
(GO:0048245)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glial cell migration
(GO:0008347)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor signaling pathway
(GO:0007186)
Helper t cell extravasation
(GO:0035684)
Heparin binding
(GO:0008201)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Intracellular calcium ion homeostasis
(GO:0006874)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Lymphocyte chemotaxis
(GO:0048247)
Macrophage chemotaxis
(GO:0048246)
Monocyte chemotaxis
(GO:0002548)
Monocyte homeostasis
(GO:0035702)
Negative regulation of angiogenesis
(GO:0016525)
Neuronal cell body
(GO:0043025)
Neutrophil chemotaxis
(GO:0030593)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of apoptotic cell clearance
(GO:2000427)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cellular extravasation
(GO:0002693)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of immune complex clearance by monocytes and macrophages
(GO:0090265)
Positive regulation of leukocyte mediated cytotoxicity
(GO:0001912)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of synaptic transmission
(GO:0050806)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Regulation of vascular endothelial growth factor production
(GO:0010574)
Response to bacterium
(GO:0009617)
Response to wounding
(GO:0009611)
Sensory perception of pain
(GO:0019233)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Other Information

Proteins

C-C motif chemokine 2

Genular Protein ID: 1219060709

Symbol: CCL2_MOUSE

Name: C-C motif chemokine 2

UniProtKB Accession Codes:

P10148 Q9QYD7

Database IDs:

Citations:

PubMed ID: 2910858

Title: Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4.

PubMed ID: 2910858

DOI: 10.1016/s0021-9258(19)84995-5

PubMed ID: 3287374

Title: Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.

PubMed ID: 3287374

DOI: 10.1073/pnas.85.11.3738

PubMed ID: 10438970

Title: Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.

PubMed ID: 10438970

PubMed ID: 2065676

Title: Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene.

PubMed ID: 2065676

DOI: 10.1111/j.1432-1033.1991.tb16113.x

PubMed ID: 23233732

Title: Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.

PubMed ID: 23233732

DOI: 10.1194/jlr.m033365

PubMed ID: 29993042

Title: Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell.

PubMed ID: 29993042

DOI: 10.1038/s41386-018-0115-8

Sequence Information:

Length: 148
Mass: 16326
Checksum: 29A5505FC6D94837
Sequence:

MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES YKRITSSRCP 
KEAVVFVTKL KREVCADPKK EWVQTYIKNL DRNQMRSEPT TLFKTASALR SSAPLNVKLT 
RKSEANASTT FSTTTSSTSV GVTSVTVN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccl2

Associated with

Other Information

Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4. PubMed ID: 2910858

Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. PubMed ID: 3287374

Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. PubMed ID: 10438970

Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene. PubMed ID: 2065676

Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. PubMed ID: 23233732