Genular: Defining Cellular Identity and Function

Details for: Ccl20

Gene ID: 20297

Symbol: Ccl20

Ensembl ID: ENSMUSG00000026166

Description: C-C motif chemokine ligand 20

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Calcium-mediated signaling using intracellular calcium source
(GO:0035584)
Ccr6 chemokine receptor binding
(GO:0031731)
Ccr chemokine receptor binding
(GO:0048020)
Cell chemotaxis
(GO:0060326)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cytokine activity
(GO:0005125)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Killing of cells of another organism
(GO:0031640)
Lymphocyte chemotaxis
(GO:0048247)
Monocyte chemotaxis
(GO:0002548)
Neutrophil chemotaxis
(GO:0030593)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of interleukin-1 alpha production
(GO:0032730)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of t cell migration
(GO:2000406)
Protein binding
(GO:0005515)
Regulation of t-helper 17 cell differentiation
(GO:2000319)
Regulation of t cell cytokine production
(GO:0002724)
T cell migration
(GO:0072678)
Thymocyte migration
(GO:0072679)

Other Information

Proteins

C-C motif chemokine 20
Q642U4_MOUSE

Genular Protein ID: 4207703094

Symbol: CCL20_MOUSE

Name: C-C motif chemokine 20

UniProtKB Accession Codes:

O89093 Q9Z1X3

Database IDs:

Citations:

PubMed ID: 9916893

Title: A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation.

PubMed ID: 9916893

DOI: 10.1016/s0165-5728(98)00204-5

PubMed ID: 9862452

Title: Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha.

PubMed ID: 9862452

DOI: 10.1016/s0014-5793(98)01450-1

PubMed ID: 10064080

Title: Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans.

PubMed ID: 10064080

DOI: 10.1002/(sici)1521-4141(199902)29:02<633::aid-immu633>3.0.co;2-i

PubMed ID: 19050256

Title: CCR6 regulates the migration of inflammatory and regulatory T cells.

PubMed ID: 19050256

DOI: 10.4049/jimmunol.181.12.8391

PubMed ID: 20068036

Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.

PubMed ID: 20068036

DOI: 10.1074/jbc.m109.091090

PubMed ID: 21376174

Title: CCR6 as a mediator of immunity in the lung and gut.

PubMed ID: 21376174

DOI: 10.1016/j.yexcr.2010.12.018

PubMed ID: 24638065

Title: CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development.

PubMed ID: 24638065

DOI: 10.1038/icb.2014.14

PubMed ID: 25122636

Title: Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.

PubMed ID: 25122636

DOI: 10.1126/scitranslmed.3009071

PubMed ID: 11373289

Title: NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6.

PubMed ID: 11373289

DOI: 10.1074/jbc.m103121200

Sequence Information:

Length: 97
Mass: 10826
Checksum: 6E0C73C8AC80AB0A
Sequence:

MACGGKRLLF LALAWVLLAH LCSQAEAASN YDCCLSYIQT PLPSRAIVGF TRQMADEACD 
INAIIFHTKK RKSVCADPKQ NWVKRAVNLL SLRVKKM

Genular Protein ID: 174043994

Symbol: Q642U4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q642U4

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 96
Mass: 10755
Checksum: A5236C18BC0E09DB
Sequence:

MACGGKRLLF LALAWVLLAH LCSQAEASNY DCCLSYIQTP LPSRAIVGFT RQMADEACDI 
NAIIFHTKKR KSVCADPKQN WVKRAVNLLS LRVKKM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccl20

Associated with

Other Information

A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation. PubMed ID: 9916893

Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha. PubMed ID: 9862452

Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. PubMed ID: 10064080

CCR6 regulates the migration of inflammatory and regulatory T cells. PubMed ID: 19050256

Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells. PubMed ID: 20068036

CCR6 as a mediator of immunity in the lung and gut. PubMed ID: 21376174

CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development. PubMed ID: 24638065

Deficient human beta-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection. PubMed ID: 25122636

NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6. PubMed ID: 11373289

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334