Details for: AK1

Gene ID: 203

Symbol: AK1

Ensembl ID: ENSG00000106992

Description: adenylate kinase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.47
    Marker Score: 2641
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.93
    Marker Score: 19119
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.76
    Marker Score: 4442
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.31
    Marker Score: 2781
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.17
    Marker Score: 18814
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.14
    Marker Score: 2405
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.95
    Marker Score: 3972
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.89
    Marker Score: 9942
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.83
    Marker Score: 730
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.79
    Marker Score: 804
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.74
    Marker Score: 573
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.58
    Marker Score: 3012
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.56
    Marker Score: 24987
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.56
    Marker Score: 1676
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.53
    Marker Score: 1148
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.48
    Marker Score: 1793
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168220
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.42
    Marker Score: 49335
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.39
    Marker Score: 1244
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.39
    Marker Score: 1309
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.38
    Marker Score: 390
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.37
    Marker Score: 487
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.36
    Marker Score: 748
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.34
    Marker Score: 3510
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.31
    Marker Score: 371
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2420.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9556
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.22
    Marker Score: 829
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.11
    Marker Score: 1771
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.11
    Marker Score: 1603
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17215
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.08
    Marker Score: 396
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.06
    Marker Score: 428
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.05
    Marker Score: 246
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.03
    Marker Score: 509
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71762
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47987
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1
    Marker Score: 1990
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.99
    Marker Score: 1807
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.98
    Marker Score: 1850
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.97
    Marker Score: 326
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.97
    Marker Score: 246
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 880
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.94
    Marker Score: 1605
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.93
    Marker Score: 4028
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.92
    Marker Score: 2176.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9
    Marker Score: 10082
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1808
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.87
    Marker Score: 256
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.87
    Marker Score: 1210
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4973
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5264
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.86
    Marker Score: 441
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.84
    Marker Score: 203
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.82
    Marker Score: 708
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.82
    Marker Score: 701
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.81
    Marker Score: 998
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.8
    Marker Score: 933
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.8
    Marker Score: 193
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.78
    Marker Score: 463
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.77
    Marker Score: 246
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.76
    Marker Score: 348
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.76
    Marker Score: 498
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.76
    Marker Score: 761
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.75
    Marker Score: 174
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.75
    Marker Score: 1149
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.74
    Marker Score: 497
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.74
    Marker Score: 349
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.74
    Marker Score: 3006
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.74
    Marker Score: 15743
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.73
    Marker Score: 523
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3022
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.72
    Marker Score: 264
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6140
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.71
    Marker Score: 666
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.7
    Marker Score: 2418
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.7
    Marker Score: 333
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.7
    Marker Score: 254
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.7
    Marker Score: 1769
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.69
    Marker Score: 1004
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.69
    Marker Score: 365
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.68
    Marker Score: 1185
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.67
    Marker Score: 671.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 442
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.67
    Marker Score: 3282.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.67
    Marker Score: 915
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.66
    Marker Score: 265
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.65
    Marker Score: 1007

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Other Information

**Key characteristics:** * AK1 is a serine/threonine kinase that is highly expressed in skeletal muscle, type II pneumocyte, pneumocyte, type I pneumocyte, ciliated columnar cell of tracheobronchial tree, peripheral nervous system neuron, GABAergic amacrine cell, epithelial cell of lung, serous secreting cell, and epithelial cell of alveolus of lung. * It is also expressed in lower levels in epithelial cells of the stomach and small intestine. * AK1 is a pleiotropic enzyme that can be activated by various substrates, including ATP, ADP, GTP, and cytidine diphosphate. * It is involved in a variety of cellular processes, including cell cycle regulation, DNA repair, and apoptosis. **Pathways and functions:** * AK1 is involved in the regulation of the adenylate cyclase/adenylate kinase (AC/AK) pathway, a signaling pathway that is involved in a variety of cellular processes, including cell cycle regulation, DNA repair, and apoptosis. * It is also involved in the regulation of the AMP-activated protein kinase (AMPK) pathway, a signaling pathway that is involved in energy metabolism. * AK1 is a key regulator of the formation of small extracellular vesicles (sEVs) by promoting the phosphorylation of the E3 ubiquitin ligase substrate protein Eps15. * It is also involved in the regulation of inflammation by promoting the production of inflammatory cytokines. **Clinical significance:** * Mutations in the AK1 gene have been linked to a number of human diseases, including cancer, heart disease, and stroke. * AK1 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * The AK1 gene is located on chromosome 15q21.1. * It is a well-documented gene with over 1000 publications in the scientific literature. * AK1 is a highly conserved gene, with a similar gene found in humans, mice, and rats.

Genular Protein ID: 511576913

Symbol: KAD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P00568 Q9BVK9 Q9UQC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 45 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 8 EMBL 4 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 2 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 9 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 183954

Title: Primary and tertiary structure of the principal human adenylate kinase.

PubMed ID: 183954

DOI: 10.1111/j.1432-1033.1976.tb10787.x

PubMed ID: 2542324

Title: Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.

PubMed ID: 2542324

DOI: 10.1016/s0021-9258(18)81779-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23416111

Title: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.

PubMed ID: 23416111

DOI: 10.1016/j.biocel.2013.02.004

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9432020

Title: Severe erythrocyte adenylate kinase deficiency due to homozygous A-->G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia.

PubMed ID: 9432020

DOI: 10.1046/j.1365-2141.1997.4953299.x

PubMed ID: 12649162

Title: Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.

PubMed ID: 12649162

DOI: 10.1182/blood-2002-07-2288

Sequence Information:

  • Length: 194
  • Mass: 21635
  • Checksum: 95EC5AAA92D1F00F
  • Sequence:
    • MEEKLKKTKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRSEVSSG SARGKKLSEI 
MEKGQLVPLE TVLDMLRDAM VAKVNTSKGF LIDGYPREVQ QGEEFERRIG QPTLLLYVDA 
GPETMTQRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV IAFYEKRGIV RKVNAEGSVD 
SVFSQVCTHL DALK

Genular Protein ID: 4205145217

Symbol: Q5T9B7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T9B7

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 45 DNASU 1 EC 8 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneTree 1 GenomeRNAi 1 HAMAP 2 HAMAP-Rule 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 9 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 210
  • Mass: 23411
  • Checksum: F04D83539371B51D
  • Sequence:
    • MGCCSSSDPR REDDLRAREK LKKTKIIFVV GGPGSGKGTQ CEKIVQKYGY THLSTGDLLR 
SEVSSGSARG KKLSEIMEKG QLVPLETVLD MLRDAMVAKV NTSKGFLIDG YPREVQQGEE 
FERRIGQPTL LLYVDAGPET MTQRLLKRGE TSGRVDDNEE TIKKRLETYY KATEPVIAFY 
EKRGIVRKVN AEGSVDSVFS QVCTHLDALK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.