Details for: AK1

Gene ID: 203

Symbol: AK1

Ensembl ID: ENSG00000106992

Description: adenylate kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.0277
    Cell Significance Index: -25.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.6000
    Cell Significance Index: -26.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.2685
    Cell Significance Index: -26.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.1830
    Cell Significance Index: -18.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6758
    Cell Significance Index: -25.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4419
    Cell Significance Index: -25.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7241
    Cell Significance Index: -14.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6880
    Cell Significance Index: -10.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.1881
    Cell Significance Index: 114.8900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.8006
    Cell Significance Index: 0.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1778
    Cell Significance Index: 13.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1459
    Cell Significance Index: 51.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0119
    Cell Significance Index: 552.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7853
    Cell Significance Index: 107.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6425
    Cell Significance Index: 14.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5708
    Cell Significance Index: 4.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5507
    Cell Significance Index: 33.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5444
    Cell Significance Index: 34.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5425
    Cell Significance Index: 69.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4828
    Cell Significance Index: 47.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4523
    Cell Significance Index: 21.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4372
    Cell Significance Index: 394.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4311
    Cell Significance Index: 86.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3740
    Cell Significance Index: 40.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3653
    Cell Significance Index: 276.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3183
    Cell Significance Index: 60.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2958
    Cell Significance Index: 53.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2786
    Cell Significance Index: 34.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2328
    Cell Significance Index: 37.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1769
    Cell Significance Index: 63.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1655
    Cell Significance Index: 11.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1431
    Cell Significance Index: 10.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1415
    Cell Significance Index: 2.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1330
    Cell Significance Index: 4.6200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.1140
    Cell Significance Index: 0.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0809
    Cell Significance Index: 2.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0654
    Cell Significance Index: 4.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0232
    Cell Significance Index: 10.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0105
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0045
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0109
    Cell Significance Index: -20.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0164
    Cell Significance Index: -25.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0194
    Cell Significance Index: -26.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0269
    Cell Significance Index: -19.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0275
    Cell Significance Index: -19.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0295
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0326
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0328
    Cell Significance Index: -20.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0387
    Cell Significance Index: -21.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0413
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0444
    Cell Significance Index: -27.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0449
    Cell Significance Index: -8.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0495
    Cell Significance Index: -22.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0689
    Cell Significance Index: -19.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0712
    Cell Significance Index: -9.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0716
    Cell Significance Index: -8.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0810
    Cell Significance Index: -3.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0937
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1117
    Cell Significance Index: -19.0800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1131
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1138
    Cell Significance Index: -13.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1305
    Cell Significance Index: -27.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1405
    Cell Significance Index: -9.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1450
    Cell Significance Index: -21.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1472
    Cell Significance Index: -10.9700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1619
    Cell Significance Index: -1.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1822
    Cell Significance Index: -4.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1831
    Cell Significance Index: -3.9000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2003
    Cell Significance Index: -1.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2086
    Cell Significance Index: -5.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2148
    Cell Significance Index: -2.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2193
    Cell Significance Index: -4.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2208
    Cell Significance Index: -26.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2323
    Cell Significance Index: -3.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2467
    Cell Significance Index: -25.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2572
    Cell Significance Index: -15.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2688
    Cell Significance Index: -17.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2792
    Cell Significance Index: -7.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2840
    Cell Significance Index: -8.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2991
    Cell Significance Index: -23.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3053
    Cell Significance Index: -20.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3128
    Cell Significance Index: -17.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3264
    Cell Significance Index: -8.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3290
    Cell Significance Index: -17.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3798
    Cell Significance Index: -16.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3824
    Cell Significance Index: -9.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3983
    Cell Significance Index: -5.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4097
    Cell Significance Index: -8.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4182
    Cell Significance Index: -10.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4212
    Cell Significance Index: -15.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4389
    Cell Significance Index: -16.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4827
    Cell Significance Index: -12.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4949
    Cell Significance Index: -11.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5059
    Cell Significance Index: -6.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5102
    Cell Significance Index: -16.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5188
    Cell Significance Index: -11.0100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.5259
    Cell Significance Index: -4.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5463
    Cell Significance Index: -17.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme function:** AK1 catalyzes the interconversion of ADP and ATP, as well as the conversion of AMP to ADP and ATP, facilitating the regulation of energy metabolism within cells. 2. **Expression pattern:** AK1 is highly expressed in skeletal muscle, lung epithelial cells, and neurons, suggesting its involvement in energy metabolism, respiratory function, and neuronal activity. 3. **Cellular localization:** AK1 is primarily found in the cytosol, with some localized to the outer dense fiber, indicating its role in regulating energy metabolism in specific cellular compartments. 4. **Protein structure:** AK1 consists of two subunits, each containing a nucleoside triphosphate adenylate kinase activity domain, enabling its efficient catalytic activity. **Pathways and Functions:** AK1 is involved in several key pathways, including: 1. **Adenylate kinase activity:** AK1 catalyzes the interconversion of ADP and ATP, regulating energy metabolism and maintaining cellular homeostasis. 2. **Adenosine triphosphate (ATP) biosynthetic process:** AK1 is essential for the production of ATP, a crucial energy currency for cells. 3. **Amp metabolic process:** AK1 facilitates the conversion of AMP to ADP and ATP, regulating the energy status of cells. 4. **Nucleoside diphosphate kinase activity:** AK1 participates in the interconversion of nucleoside diphosphates, maintaining the balance of energy metabolites. **Clinical Significance:** Dysregulation of AK1 has been implicated in various diseases, including: 1. **Muscle disorders:** AK1 has been linked to muscle fatigue, weakness, and wasting, highlighting its importance in maintaining muscle energy homeostasis. 2. **Respiratory diseases:** AK1 expression in lung epithelial cells suggests its role in regulating respiratory function and maintaining lung homeostasis. 3. **Neurological disorders:** AK1 has been implicated in neuronal energy metabolism, with dysregulation contributing to neurological diseases, such as Alzheimer's and Parkinson's. In conclusion, AK1 is a crucial enzyme involved in energy metabolism, with implications for various cellular processes and diseases. Further research is needed to fully elucidate the mechanisms of AK1 and its role in human disease.

Genular Protein ID: 511576913

Symbol: KAD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P00568 Q9BVK9 Q9UQC7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 73 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 7 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 2 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 16 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 183954

Title: Primary and tertiary structure of the principal human adenylate kinase.

PubMed ID: 183954

DOI: 10.1111/j.1432-1033.1976.tb10787.x

PubMed ID: 2542324

Title: Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.

PubMed ID: 2542324

DOI: 10.1016/s0021-9258(18)81779-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21080915

Title: The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes.

PubMed ID: 21080915

DOI: 10.1042/bj20101443

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23416111

Title: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.

PubMed ID: 23416111

DOI: 10.1016/j.biocel.2013.02.004

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9432020

Title: Severe erythrocyte adenylate kinase deficiency due to homozygous A-->G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia.

PubMed ID: 9432020

DOI: 10.1046/j.1365-2141.1997.4953299.x

PubMed ID: 12649162

Title: Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.

PubMed ID: 12649162

DOI: 10.1182/blood-2002-07-2288

Sequence Information:

  • Length: 194
  • Mass: 21635
  • Checksum: 95EC5AAA92D1F00F
  • Sequence:
    • MEEKLKKTKI IFVVGGPGSG KGTQCEKIVQ KYGYTHLSTG DLLRSEVSSG SARGKKLSEI 
MEKGQLVPLE TVLDMLRDAM VAKVNTSKGF LIDGYPREVQ QGEEFERRIG QPTLLLYVDA 
GPETMTQRLL KRGETSGRVD DNEETIKKRL ETYYKATEPV IAFYEKRGIV RKVNAEGSVD 
SVFSQVCTHL DALK

Genular Protein ID: 4205145217

Symbol: Q5T9B7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5T9B7

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 45 DNASU 1 DisGeNET 1 EC 8 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 HAMAP 2 HAMAP-Rule 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 9 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 210
  • Mass: 23411
  • Checksum: F04D83539371B51D
  • Sequence:
    • MGCCSSSDPR REDDLRAREK LKKTKIIFVV GGPGSGKGTQ CEKIVQKYGY THLSTGDLLR 
SEVSSGSARG KKLSEIMEKG QLVPLETVLD MLRDAMVAKV NTSKGFLIDG YPREVQQGEE 
FERRIGQPTL LLYVDAGPET MTQRLLKRGE TSGRVDDNEE TIKKRLETYY KATEPVIAFY 
EKRGIVRKVN AEGSVDSVFS QVCTHLDALK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.