Genular: Defining Cellular Identity and Function

Details for: Ccl3

Gene ID: 20302

Symbol: Ccl3

Ensembl ID: ENSMUSG00000000982

Description: C-C motif chemokine ligand 3

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Astrocyte cell migration
(GO:0043615)
Ccr1 chemokine receptor binding
(GO:0031726)
Ccr5 chemokine receptor binding
(GO:0031730)
Ccr chemokine receptor binding
(GO:0048020)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemoattractant activity
(GO:0042056)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Eosinophil chemotaxis
(GO:0048245)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Kinase activity
(GO:0016301)
Leukocyte chemotaxis
(GO:0030595)
Lymphocyte chemotaxis
(GO:0048247)
Macrophage chemotaxis
(GO:0048246)
Monocyte chemotaxis
(GO:0002548)
Neutrophil chemotaxis
(GO:0030593)
Phospholipase activator activity
(GO:0016004)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Regulation of cell shape
(GO:0008360)
Regulation of programmed cell death
(GO:0043067)

Other Information

Proteins

C-C motif chemokine 3

Genular Protein ID: 2892552628

Symbol: CCL3_MOUSE

Name: C-C motif chemokine 3

UniProtKB Accession Codes:

P10855 P14096

Database IDs:

Citations:

PubMed ID: 3290382

Title: Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties.

PubMed ID: 3290382

DOI: 10.1084/jem.167.6.1939

PubMed ID: 2521353

Title: A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

PubMed ID: 2521353

PubMed ID: 2216738

Title: Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene.

PubMed ID: 2216738

DOI: 10.1093/nar/18.18.5561

PubMed ID: 2784565

Title: cDNA sequences of two inducible T-cell genes.

PubMed ID: 2784565

DOI: 10.1073/pnas.86.6.1963

PubMed ID: 2033269

Title: Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78.

PubMed ID: 2033269

PubMed ID: 10438970

Title: Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.

PubMed ID: 10438970

PubMed ID: 3279154

Title: Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.

PubMed ID: 3279154

DOI: 10.1084/jem.167.2.570

Sequence Information:

Length: 92
Mass: 10345
Checksum: 8BFF2DE7C6DEDD38
Sequence:

MKVSTTALAV LLCTMTLCNQ VFSAPYGADT PTACCFSYSR KIPRQFIVDY FETSSLCSQP 
GVIFLTKRNR QICADSKETW VQEYITDLEL NA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccl3

Associated with

Other Information

Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties. PubMed ID: 3290382

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. PubMed ID: 2521353

Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene. PubMed ID: 2216738

cDNA sequences of two inducible T-cell genes. PubMed ID: 2784565

Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78. PubMed ID: 2033269

Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. PubMed ID: 10438970

Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. PubMed ID: 3279154