Genular: Defining Cellular Identity and Function

Details for: Ccl5

Gene ID: 20304

Symbol: Ccl5

Ensembl ID: ENSMUSG00000035042

Description: C-C motif chemokine ligand 5

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Activation of phospholipase d activity
(GO:0031584)
Calcium ion transport
(GO:0006816)
Ccr1 chemokine receptor binding
(GO:0031726)
Ccr5 chemokine receptor binding
(GO:0031730)
Ccr chemokine receptor binding
(GO:0048020)
Cell-cell signaling
(GO:0007267)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemoattractant activity
(GO:0042056)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemokine receptor antagonist activity
(GO:0046817)
Chemokine receptor binding
(GO:0042379)
Chemotaxis
(GO:0006935)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Eosinophil chemotaxis
(GO:0048245)
Epithelial cell proliferation
(GO:0050673)
Exocytosis
(GO:0006887)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Intracellular calcium ion homeostasis
(GO:0006874)
Leukocyte cell-cell adhesion
(GO:0007159)
Lymphocyte chemotaxis
(GO:0048247)
Monocyte chemotaxis
(GO:0002548)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of macrophage apoptotic process
(GO:2000110)
Negative regulation of t cell apoptotic process
(GO:0070233)
Negative regulation of viral genome replication
(GO:0045071)
Neutrophil activation
(GO:0042119)
Neutrophil chemotaxis
(GO:0030593)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase activator activity
(GO:0016004)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cell-cell adhesion mediated by integrin
(GO:0033634)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cellular biosynthetic process
(GO:0031328)
Positive regulation of chemokine (c-x-c motif) ligand 2 production
(GO:2000343)
Positive regulation of defense response to virus by host
(GO:0002230)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of homotypic cell-cell adhesion
(GO:0034112)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of mast cell chemotaxis
(GO:0060754)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of natural killer cell chemotaxis
(GO:2000503)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of t cell apoptotic process
(GO:0070234)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of t cell migration
(GO:2000406)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein self-association
(GO:0043621)
Pseudopodium assembly
(GO:0031269)
Receptor signaling protein tyrosine kinase activator activity
(GO:0030298)
Regulation of insulin secretion
(GO:0050796)
Regulation of programmed cell death
(GO:0043067)
Regulation of t cell activation
(GO:0050863)
Response to cytokine
(GO:0034097)
Response to toxic substance
(GO:0009636)
Response to tumor necrosis factor
(GO:0034612)
Response to type ii interferon
(GO:0034341)
T-helper 1 cell diapedesis
(GO:0035688)

Other Information

Proteins

C-C motif chemokine 5

Genular Protein ID: 434754814

Symbol: CCL5_MOUSE

Name: C-C motif chemokine 5

UniProtKB Accession Codes:

P30882

Database IDs:

Citations:

PubMed ID: 1375672

Title: Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes.

PubMed ID: 1375672

DOI: 10.1038/ki.1992.31

PubMed ID: 1376260

Title: Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man.

PubMed ID: 1376260

DOI: 10.1002/eji.1830220621

PubMed ID: 7507961

Title: Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES.

PubMed ID: 7507961

PubMed ID: 7513046

Title: Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2.

PubMed ID: 7513046

DOI: 10.1128/mcb.14.5.2914-2925.1994

PubMed ID: 10438970

Title: Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.

PubMed ID: 10438970

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 91
Mass: 10071
Checksum: 5DFD66F4684FE1C8
Sequence:

MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY FYTSSKCSNL 
AVVFVTRRNR QVCANPEKKW VQEYINYLEM S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccl5

Associated with

Other Information

Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes. PubMed ID: 1375672

Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man. PubMed ID: 1376260

Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES. PubMed ID: 7507961

Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2. PubMed ID: 7513046

Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. PubMed ID: 10438970

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334