Genular: Defining Cellular Identity and Function

Details for: Cx3cl1

Gene ID: 20312

Symbol: Cx3cl1

Ensembl ID: ENSMUSG00000031778

Description: C-X3-C motif chemokine ligand 1

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Angiogenesis involved in wound healing
(GO:0060055)
Autocrine signaling
(GO:0035425)
Ccr chemokine receptor binding
(GO:0048020)
Cell-cell adhesion
(GO:0098609)
Cell adhesion
(GO:0007155)
Cell body
(GO:0044297)
Cell chemotaxis
(GO:0060326)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Chemoattractant activity
(GO:0042056)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemotaxis
(GO:0006935)
Cx3c chemokine receptor binding
(GO:0031737)
Cxcr1 chemokine receptor binding
(GO:0045237)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Eosinophil chemotaxis
(GO:0048245)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Inhibitory postsynaptic potential
(GO:0060080)
Integrin activation
(GO:0033622)
Integrin binding
(GO:0005178)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Lymphocyte chemotaxis
(GO:0048247)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Microglial cell proliferation
(GO:0061518)
Monocyte chemotaxis
(GO:0002548)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of glutamate receptor signaling pathway
(GO:1900450)
Negative regulation of hippocampal neuron apoptotic process
(GO:0110091)
Negative regulation of interleukin-1 alpha production
(GO:0032690)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of vasoconstriction
(GO:0045906)
Neuronal cell body
(GO:0043025)
Neuron cellular homeostasis
(GO:0070050)
Neuron projection
(GO:0043005)
Neutrophil chemotaxis
(GO:0030593)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive chemotaxis
(GO:0050918)
Positive regulation of actin filament bundle assembly
(GO:0032233)
Positive regulation of calcium-independent cell-cell adhesion
(GO:0051041)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of i-kappab phosphorylation
(GO:1903721)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of microglial cell migration
(GO:1904141)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta1 production
(GO:0032914)
Regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031664)
Response to ischemia
(GO:0002931)
Wound healing
(GO:0042060)

Other Information

Proteins

Small-inducible cytokine D1

Genular Protein ID: 473165635

Symbol: X3CL1_MOUSE

Name: Small-inducible cytokine D1

UniProtKB Accession Codes:

O35188 O35933 Q91V44

Database IDs:

Citations:

PubMed ID: 9177350

Title: Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.

PubMed ID: 9177350

DOI: 10.1038/42491

PubMed ID: 9479488

Title: Cloning and characterization of a new type of mouse chemokine.

PubMed ID: 9479488

DOI: 10.1006/geno.1997.5058

PubMed ID: 10382755

Title: Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.

PubMed ID: 10382755

DOI: 10.1002/(sici)1521-4141(199906)29:06<1925::aid-immu1925>3.0.co;2-u

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9845323

Title: Neuronal expression of fractalkine in the presence and absence of inflammation.

PubMed ID: 9845323

DOI: 10.1016/s0014-5793(98)01384-2

PubMed ID: 10508268

Title: Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation.

PubMed ID: 10508268

DOI: 10.1002/(sici)1521-4141(199909)29:09<2934::aid-immu2934>3.0.co;2-q

PubMed ID: 10187784

Title: Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation.

PubMed ID: 10187784

DOI: 10.1074/jbc.274.15.10053

PubMed ID: 11287620

Title: Generation and analysis of mice lacking the chemokine fractalkine.

PubMed ID: 11287620

DOI: 10.1128/mcb.21.9.3159-3165.2001

PubMed ID: 12569158

Title: Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.

PubMed ID: 12569158

DOI: 10.1172/jci15555

PubMed ID: 18971423

Title: CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

PubMed ID: 18971423

DOI: 10.1182/blood-2008-07-170787

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 395
Mass: 42099
Checksum: B5A16F8BD4B80340
Sequence:

MAPSPLAWLL RLAAFFHLCT LLPGQHLGMT KCEIMCDKMT SRIPVALLIR YQLNQESCGK 
RAIVLETTQH RRFCADPKEK WVQDAMKHLD HQAAALTKNG GKFEKRVDNV TPGITLATRG 
LSPSALTKPE SATLEDLALE LTTISQEARG TMGTSQEPPA AVTGSSLSTS EAQDAGLTAK 
PQSIGSFEAA DISTTVWPSP AVYQSGSSSW AEEKATESPS TTAPSPQVST TSPSTPEENV 
GSEGQPPWVQ GQDLSPEKSL GSEEINPVHT DNFQERGPGN TVHPSVAPIS SEETPSPELV 
ASGSQAPKIE EPIHATADPQ KLSVLITPVP DTQAATRRQA VGLLAFLGLL FCLGVAMFAY 
QSLQGCPRKM AGEMVEGLRY VPRSCGSNSY VLVPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cx3cl1

Associated with

Other Information

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. PubMed ID: 9177350

Cloning and characterization of a new type of mouse chemokine. PubMed ID: 9479488

Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells. PubMed ID: 10382755

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Neuronal expression of fractalkine in the presence and absence of inflammation. PubMed ID: 9845323

Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation. PubMed ID: 10508268

Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation. PubMed ID: 10187784

Generation and analysis of mice lacking the chemokine fractalkine. PubMed ID: 11287620

Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. PubMed ID: 12569158

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. PubMed ID: 18971423

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079