Details for: Sfrp2

Gene ID: 20319

Symbol: Sfrp2

Ensembl ID: ENSMUSG00000027996

Description: secreted frizzled-related protein 2

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Apoptotic process
    (GO:0006915)
  • Bmp signaling pathway
    (GO:0030509)
  • Branching involved in blood vessel morphogenesis
    (GO:0001569)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cardiac left ventricle morphogenesis
    (GO:0003214)
  • Cardiac muscle cell apoptotic process
    (GO:0010659)
  • Cartilage development
    (GO:0051216)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to extracellular stimulus
    (GO:0031668)
  • Cellular response to x-ray
    (GO:0071481)
  • Chondrocyte development
    (GO:0002063)
  • Collagen fibril organization
    (GO:0030199)
  • Convergent extension involved in axis elongation
    (GO:0060028)
  • Development of primary male sexual characteristics
    (GO:0046546)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Embryonic digit morphogenesis
    (GO:0042733)
  • Endopeptidase activator activity
    (GO:0061133)
  • Enzyme activator activity
    (GO:0008047)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Hematopoietic stem cell proliferation
    (GO:0071425)
  • Male gonad development
    (GO:0008584)
  • Mesodermal cell fate specification
    (GO:0007501)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dermatome development
    (GO:0061185)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902042)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of jun kinase activity
    (GO:0043508)
  • Negative regulation of mesodermal cell fate specification
    (GO:0042662)
  • Negative regulation of peptidyl-tyrosine phosphorylation
    (GO:0050732)
  • Negative regulation of planar cell polarity pathway involved in axis elongation
    (GO:2000041)
  • Negative regulation of wnt signaling pathway
    (GO:0030178)
  • Neural tube closure
    (GO:0001843)
  • Neural tube development
    (GO:0021915)
  • Non-canonical wnt signaling pathway
    (GO:0035567)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Planar cell polarity pathway involved in axis elongation
    (GO:0003402)
  • Planar cell polarity pathway involved in neural tube closure
    (GO:0090179)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of endopeptidase activity
    (GO:0010950)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-anal tail morphogenesis
    (GO:0036342)
  • Protein binding
    (GO:0005515)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of establishment of planar polarity
    (GO:0090175)
  • Regulation of midbrain dopaminergic neuron differentiation
    (GO:1904956)
  • Regulation of neuron projection development
    (GO:0010975)
  • Regulation of stem cell division
    (GO:2000035)
  • Regulation of wnt signaling pathway
    (GO:0030111)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Sclerotome development
    (GO:0061056)
  • Somitogenesis
    (GO:0001756)
  • Stem cell fate specification
    (GO:0048866)
  • Wnt-protein binding
    (GO:0017147)
  • Wnt signaling pathway
    (GO:0016055)
  • Wnt signaling pathway involved in somitogenesis
    (GO:0090244)

Other Information

Genular Protein ID: 3700802920

Symbol: SFRP2_MOUSE

Name: Protein SDF5

UniProtKB Accession Codes:

P97299 O08862 O35297

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 70 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MEROPS 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8938438

Title: Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.

PubMed ID: 8938438

DOI: 10.1006/geno.1996.0560

PubMed ID: 9096311

Title: A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

PubMed ID: 9096311

DOI: 10.1073/pnas.94.7.2859

PubMed ID: 9391078

Title: SARPs: a family of secreted apoptosis-related proteins.

PubMed ID: 9391078

DOI: 10.1073/pnas.94.25.13636

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9739103

Title: Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.

PubMed ID: 9739103

DOI: 10.1016/s0925-4773(98)00072-0

PubMed ID: 15226823

Title: Genomic analysis of mouse retinal development.

PubMed ID: 15226823

DOI: 10.1371/journal.pbio.0020247

PubMed ID: 27713059

Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.

PubMed ID: 27713059

DOI: 10.1016/j.ydbio.2016.10.001

Sequence Information:

  • Length: 295
  • Mass: 33469
  • Checksum: 2D287C177C974C62
  • Sequence:
    • MPRGPASLLL LVLASHCCLG SARGLFLFGQ PDFSYKRSNC KPIPANLQLC HGIEYQNMRL 
PNLLGHETMK EVLEQAGAWI PLVMKQCHPD TKKFLCSLFA PVCLDDLDET IQPCHSLCVQ 
VKDRCAPVMS AFGFPWPDML ECDRFPQDND LCIPLASSDH LLPATEEAPK VCEACKTKNE 
DDNDIMETLC KNDFALKIKV KEITYINRDT KIILETKSKT IYKLNGVSER DLKKSVLWLK 
DSLQCTCEEM NDINAPYLVM GQKQGGELVI TSVKRWQKGQ REFKRISRSI RKLQC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.