Genular: Defining Cellular Identity and Function

Details for: Sema4a

Gene ID: 20351

Symbol: Sema4a

Ensembl ID: ENSMUSG00000028064

Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

Associated with

Developmental biology
(R-MMU-1266738)
Other semaphorin interactions
(R-MMU-416700)
Semaphorin interactions
(R-MMU-373755)
Adaptive immune response
(GO:0002250)
Angiogenesis
(GO:0001525)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Cell differentiation
(GO:0030154)
Chemorepellent activity
(GO:0045499)
Immune system process
(GO:0002376)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative chemotaxis
(GO:0050919)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of excitatory synapse assembly
(GO:1904891)
Positive regulation of inhibitory synapse assembly
(GO:1905704)
Regulation of cell shape
(GO:0008360)
Regulation of endothelial cell migration
(GO:0010594)
Semaphorin-plexin signaling pathway
(GO:0071526)
Semaphorin receptor binding
(GO:0030215)
T-helper 1 cell differentiation
(GO:0045063)
T cell differentiation involved in immune response
(GO:0002292)

Other Information

Proteins

Semaphorin-4A

Genular Protein ID: 2703909961

Symbol: SEM4A_MOUSE

Name: Semaphorin-4A

UniProtKB Accession Codes:

Q62178 D3Z5L2

Database IDs:

Citations:

PubMed ID: 7748561

Title: Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension.

PubMed ID: 7748561

DOI: 10.1016/0896-6273(95)90332-1

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 12374982

Title: Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.

PubMed ID: 12374982

DOI: 10.1038/nature01037

PubMed ID: 15277503

Title: Severe retinal degeneration associated with disruption of semaphorin 4A.

PubMed ID: 15277503

DOI: 10.1167/iovs.04-0020

PubMed ID: 15780988

Title: Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.

PubMed ID: 15780988

DOI: 10.1016/j.immuni.2005.01.014

PubMed ID: 17318185

Title: Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via plexin-D1.

PubMed ID: 17318185

DOI: 10.1038/sj.emboj.7601589

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20043131

Title: Sema4A induces cell morphological changes through B-type plexin-mediated signaling.

PubMed ID: 20043131

PubMed ID: 29981480

Title: Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus.

PubMed ID: 29981480

DOI: 10.1016/j.mcn.2018.06.008

Sequence Information:

Length: 760
Mass: 83421
Checksum: C13BD31BD90BE3D9
Sequence:

MALPSLGQDS WSLLRVFFFQ LFLLPSLPPA SGTGGQGPMP RVKYHAGDGH RALSFFQQKG 
LRDFDTLLLS DDGNTLYVGA REAVLALNIQ NPGIPRLKNM IPWPASERKK TECAFKKKSN 
ETQCFNFIRV LVSYNATHLY ACGTFAFSPA CTFIELQDSL LLPILIDKVM DGKGQSPFDP 
VHKHTAVLVD GMLYSGTMNN FLGSEPILMR TLGSQPVLKT DIFLRWLHAD ASFVAAIPST 
QVVYFFFEET ASEFDFFEEL YISRVAQVCK NDVGGEKLLQ KKWTTFLKAQ LLCAQPGQLP 
FNIIRHAVLL PADSPSVSRI YAVFTSQWQV GGTRSSAVCA FSLTDIERVF KGKYKELNKE 
TSRWTTYRGS EVSPRPGSCS MGPSSDKALT FMKDHFLMDE HVVGTPLLVK SGVEYTRLAV 
ESARGLDGSS HVVMYLGTST GSLHKAVVPQ DSSAYLVEEI QLSPDSEPVR NLQLAPAQGA 
VFAGFSGGIW RVPRANCSVY ESCVDCVLAR DPHCAWDPES RLCSLLSGST KPWKQDMERG 
NPEWVCTRGP MARSPRRQSP PQLIKEVLTV PNSILELPCP HLSALASYHW SHGRAKISEA 
SATVYNGSLL LLPQDGVGGL YQCVATENGY SYPVVSYWVD SQDQPLALDP ELAGVPRERV 
QVPLTRVGGG ASMAAQRSYW PHFLIVTVLL AIVLLGVLTL LLASPLGALR ARGKVQGCGM 
LPPREKAPLS RDQHLQPSKD HRTSASDVDA DNNHLGAEVA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sema4a

Associated with

Other Information

Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. PubMed ID: 7748561

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. PubMed ID: 12374982

Severe retinal degeneration associated with disruption of semaphorin 4A. PubMed ID: 15277503

Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice. PubMed ID: 15780988

Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via plexin-D1. PubMed ID: 17318185

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sema4A induces cell morphological changes through B-type plexin-mediated signaling. PubMed ID: 20043131

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus. PubMed ID: 29981480