Genular: Defining Cellular Identity and Function

Details for: Sema4d

Gene ID: 20354

Symbol: Sema4d

Ensembl ID: ENSMUSG00000021451

Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

Associated with

Developmental biology
(R-MMU-1266738)
Other semaphorin interactions
(R-MMU-416700)
Sema4d induced cell migration and growth-cone collapse
(R-MMU-416572)
Sema4d in semaphorin signaling
(R-MMU-400685)
Sema4d mediated inhibition of cell attachment and migration
(R-MMU-416550)
Semaphorin interactions
(R-MMU-373755)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Bone trabecula morphogenesis
(GO:0061430)
Cell differentiation
(GO:0030154)
Chemorepellent activity
(GO:0045499)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Leukocyte aggregation
(GO:0070486)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative chemotaxis
(GO:0050919)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of peptidyl-tyrosine phosphorylation
(GO:0050732)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Ossification involved in bone maturation
(GO:0043931)
Plasma membrane
(GO:0005886)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of inhibitory synapse assembly
(GO:1905704)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of rho protein signal transduction
(GO:0035025)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of cell projection organization
(GO:0031344)
Regulation of cell shape
(GO:0008360)
Regulation of dendrite morphogenesis
(GO:0048814)
Semaphorin-plexin signaling pathway
(GO:0071526)
Semaphorin receptor binding
(GO:0030215)
Semaphorin receptor complex
(GO:0002116)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

Semaphorin-4D

Genular Protein ID: 1976631013

Symbol: SEM4D_MOUSE

Name: Semaphorin-4D

UniProtKB Accession Codes:

O09126 Q6GTM9

Database IDs:

Citations:

PubMed ID: 8969198

Title: Identification of a novel transmembrane semaphorin expressed on lymphocytes.

PubMed ID: 8969198

DOI: 10.1074/jbc.271.52.33376

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17554007

Title: Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.

PubMed ID: 17554007

DOI: 10.1523/jneurosci.5381-06.2007

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23699507

Title: The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus.

PubMed ID: 23699507

DOI: 10.1523/jneurosci.0989-13.2013

PubMed ID: 29981480

Title: Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus.

PubMed ID: 29981480

DOI: 10.1016/j.mcn.2018.06.008

Sequence Information:

Length: 861
Mass: 95640
Checksum: B962D4E4CF37FFD9
Sequence:

MRMCAPVRGL FLALVVVLRT AVAFAPVPRL TWEHGEVGLV QFHKPGIFNY SALLMSEDKD 
TLYVGAREAV FAVNALNISE KQHEVYWKVS EDKKSKCAEK GKSKQTECLN YIRVLQPLSS 
TSLYVCGTNA FQPTCDHLNL TSFKFLGKSE DGKGRCPFDP AHSYTSVMVG GELYSGTSYN 
FLGSEPIISR NSSHSPLRTE YAIPWLNEPS FVFADVIQKS PDGPEGEDDK VYFFFTEVSV 
EYEFVFKLMI PRVARVCKGD QGGLRTLQKK WTSFLKARLI CSKPDSGLVF NILQDVFVLR 
APGLKEPVFY AVFTPQLNNV GLSAVCAYTL ATVEAVFSRG KYMQSATVEQ SHTKWVRYNG 
PVPTPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM DDSVTPIDNR PKLIKKDVNY 
TQIVVDRTQA LDGTFYDVMF ISTDRGALHK AVILTKEVHV IEETQLFRDS EPVLTLLLSS 
KKGRKFVYAG SNSGVVQAPL AFCEKHGSCE DCVLARDPYC AWSPAIKACV TLHQEEASSR 
GWIQDMSGDT SSCLDKSKES FNQHFFKHGG TAELKCFQKS NLARVVWKFQ NGELKAASPK 
YGFVGRKHLL IFNLSDGDSG VYQCLSEERV RNKTVSQLLA KHVLEVKMVP RTPPSPTSED 
AQTEGSKITS KMPVASTQGS SPPTPALWAT SPRAATLPPK SSSGTSCEPK MVINTVPQLH 
SEKTVYLKSS DNRLLMSLLL FIFVLFLCLF SYNCYKGYLP GQCLKFRSAL LLGKKTPKSD 
FSDLEQSVKE TLVEPGSFSQ QNGDHPKPAL DTGYETEQDT ITSKVPTDRE DSQRIDELSA 
RDKPFDVKCE LKFADSDADG D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sema4d

Associated with

Other Information

Identification of a novel transmembrane semaphorin expressed on lymphocytes. PubMed ID: 8969198

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. PubMed ID: 17554007

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The class 4 semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. PubMed ID: 23699507

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus. PubMed ID: 29981480