Genular: Defining Cellular Identity and Function

Details for: Sema7a

Gene ID: 20361

Symbol: Sema7a

Ensembl ID: ENSMUSG00000038264

Description: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A

Associated with

Developmental biology
(R-MMU-1266738)
Other semaphorin interactions
(R-MMU-416700)
Semaphorin interactions
(R-MMU-373755)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Cell differentiation
(GO:0030154)
Chemorepellent activity
(GO:0045499)
External side of plasma membrane
(GO:0009897)
Inflammatory response
(GO:0006954)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative chemotaxis
(GO:0050919)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Neuron projection development
(GO:0031175)
Olfactory lobe development
(GO:0021988)
Plasma membrane
(GO:0005886)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein phosphorylation
(GO:0006468)
Regulation of inflammatory response
(GO:0050727)
Semaphorin-plexin signaling pathway
(GO:0071526)
Semaphorin receptor binding
(GO:0030215)
Side of membrane
(GO:0098552)

Other Information

Proteins

Semaphorin-7A

Genular Protein ID: 2650402049

Symbol: SEM7A_MOUSE

Name: Semaphorin-7A

UniProtKB Accession Codes:

Q9QUR8 O88371

Database IDs:

Citations:

PubMed ID: 9878861

Title: Molecular cloning and expression of murine homologue of semaphorin K1 gene.

PubMed ID: 9878861

DOI: 10.1016/s0167-4781(98)00245-0

PubMed ID: 9721204

Title: New eukaryotic semaphorins with close homology to semaphorins of DNA viruses.

PubMed ID: 9721204

DOI: 10.1006/geno.1998.5256

PubMed ID: 10885563

Title: CDw108 expression during T-cell development.

PubMed ID: 10885563

DOI: 10.1034/j.1399-0039.2000.550505.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12879062

Title: Semaphorin 7A promotes axon outgrowth through integrins and MAPKs.

PubMed ID: 12879062

DOI: 10.1038/nature01790

PubMed ID: 16713976

Title: Semaphorin 7A is a negative regulator of T cell responses.

PubMed ID: 16713976

DOI: 10.1016/j.immuni.2006.03.013

PubMed ID: 17377534

Title: Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.

PubMed ID: 17377534

DOI: 10.1038/nature05652

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 34585848

Title: A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.

PubMed ID: 34585848

DOI: 10.15252/emmm.202114563

Sequence Information:

Length: 664
Mass: 74994
Checksum: 1804A31C3C55B715
Sequence:

MTPPPPGRAA PSAPRARVLS LPARFGLPLR LRLLLVFWVA AASAQGHSRS GPRISAVWKG 
QDHVDFSQPE PHTVLFHEPG SFSVWVGGRG KVYHFNFPEG KNASVRTVNI GSTKGSCQDK 
QDCGNYITLL ERRGNGLLVC GTNARKPSCW NLVNDSVVMS LGEMKGYAPF SPDENSLVLF 
EGDEVYSTIR KQEYNGKIPR FRRIRGESEL YTSDTVMQNP QFIKATIVHQ DQAYDDKIYY 
FFREDNPDKN PEAPLNVSRV AQLCRGDQGG ESSLSVSKWN TFLKAMLVCS DAATNRNFNR 
LQDVFLLPDP SGQWRDTRVY GVFSNPWNYS AVCVYSLGDI DRVFRTSSLK GYHMGLPNPR 
PGMCLPKKQP IPTETFQVAD SHPEVAQRVE PMGPLKTPLF HSKYHYQKVV VHRMQASNGE 
TFHVLYLTTD RGTIHKVVES GDQDHSFVFN IMEIQPFHRA AAIQAISLDA DRRKLYVTSQ 
WEVSQVPLDM CEVYSGGCHG CLMSRDPYCG WDQDRCVSIY SSQRSVLQSI NPAEPHRECP 
NPKPDEAPLQ KVSLARNSRY YLTCPMESRH ATYLWRHEEN VEQSCEPGHQ SPSCILFIEN 
LTARQYGHYR CEAQEGSYLR EAQHWELLPE DRALAEQLMG HARALAASFW LGVLPTLILG 
LLVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sema7a

Associated with

Other Information

Molecular cloning and expression of murine homologue of semaphorin K1 gene. PubMed ID: 9878861

New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. PubMed ID: 9721204

CDw108 expression during T-cell development. PubMed ID: 10885563

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. PubMed ID: 12879062

Semaphorin 7A is a negative regulator of T cell responses. PubMed ID: 16713976

Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. PubMed ID: 17377534

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis. PubMed ID: 34585848