Details for: Foxp3

Gene ID: 20371

Symbol: Foxp3

Ensembl ID: ENSMUSG00000039521

Description: forkhead box P3

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
    (R-MMU-8877330)
  • Transcriptional regulation by runx1
    (R-MMU-8878171)
  • B cell homeostasis
    (GO:0001782)
  • Cd4-positive, alpha-beta t cell proliferation
    (GO:0035739)
  • Cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation
    (GO:0002361)
  • Cd4-positive, cd25-positive, alpha-beta regulatory t cell lineage commitment
    (GO:0002362)
  • Chromatin remodeling
    (GO:0006338)
  • Cytokine production
    (GO:0001816)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Gene expression
    (GO:0010467)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Histone deacetylase binding
    (GO:0042826)
  • Identical protein binding
    (GO:0042802)
  • Immature t cell proliferation in thymus
    (GO:0033080)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-2 production
    (GO:0032623)
  • Interleukin-4 production
    (GO:0032633)
  • Interleukin-5 production
    (GO:0032634)
  • Interleukin-6 production
    (GO:0032635)
  • Interleukin-10 production
    (GO:0032613)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell homeostasis
    (GO:0002262)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chronic inflammatory response
    (GO:0002677)
  • Negative regulation of creb transcription factor activity
    (GO:0032792)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of interleukin-4 production
    (GO:0032713)
  • Negative regulation of interleukin-5 production
    (GO:0032714)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of t cell cytokine production
    (GO:0002725)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Nfat protein binding
    (GO:0051525)
  • Positive regulation of cd4-positive, cd25-positive, alpha-beta regulatory t cell differentiation
    (GO:0032831)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of immature t cell proliferation in thymus
    (GO:0033092)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of peripheral t cell tolerance induction
    (GO:0002851)
  • Positive regulation of t cell anergy
    (GO:0002669)
  • Positive regulation of t cell tolerance induction
    (GO:0002666)
  • Positive regulation of transforming growth factor beta1 production
    (GO:0032914)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of immunoglobulin production
    (GO:0002637)
  • Regulation of t cell anergy
    (GO:0002667)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • T cell anergy
    (GO:0002870)
  • T cell mediated immunity
    (GO:0002456)
  • T cell proliferation
    (GO:0042098)
  • T cell tolerance induction
    (GO:0002517)
  • Tolerance induction
    (GO:0002507)
  • Tolerance induction to self antigen
    (GO:0002513)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription corepressor activity
    (GO:0003714)
  • Transforming growth factor beta1 production
    (GO:0032905)
  • Tumor necrosis factor production
    (GO:0032640)
  • Type ii interferon production
    (GO:0032609)

Other Information

Genular Protein ID: 3136138029

Symbol: FOXP3_MOUSE

Name: Forkhead box protein P3

UniProtKB Accession Codes:

Q99JB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 EMBL 3 Ensembl 6 ExpressionAtlas 1 GO 91 Gene3D 2 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 11138001

Title: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

PubMed ID: 11138001

DOI: 10.1038/83784

PubMed ID: 15790681

Title: Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.

PubMed ID: 15790681

DOI: 10.1073/pnas.0501675102

PubMed ID: 16769892

Title: The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.

PubMed ID: 16769892

DOI: 10.1073/pnas.0600225103

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 18368049

Title: TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

PubMed ID: 18368049

DOI: 10.1038/nature06878

PubMed ID: 19117830

Title: Foxp3 processing by proprotein convertases and control of regulatory T cell function.

PubMed ID: 19117830

DOI: 10.1074/jbc.m807322200

PubMed ID: 19696312

Title: Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.

PubMed ID: 19696312

DOI: 10.1126/science.1176077

PubMed ID: 22312127

Title: Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.

PubMed ID: 22312127

DOI: 10.4049/jimmunol.1100903

PubMed ID: 23973222

Title: Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

PubMed ID: 23973222

DOI: 10.1016/j.immuni.2013.05.018

PubMed ID: 23973223

Title: The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

PubMed ID: 23973223

DOI: 10.1016/j.immuni.2013.08.006

PubMed ID: 23853094

Title: Foxp3 protein stability is regulated by cyclin-dependent kinase 2.

PubMed ID: 23853094

DOI: 10.1074/jbc.m113.467704

PubMed ID: 24722479

Title: FOXP3 and scurfy: how it all began.

PubMed ID: 24722479

DOI: 10.1038/nri3650

PubMed ID: 22813742

Title: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.

PubMed ID: 22813742

DOI: 10.1016/j.celrep.2012.04.012

Sequence Information:

  • Length: 429
  • Mass: 47346
  • Checksum: 28D5B8E67891840C
  • Sequence:
    • MPNPRPAKPM APSLALGPSP GVLPSWKTAP KGSELLGTRG SGGPFQGRDL RSGAHTSSSL 
NPLPPSQLQL PTVPLVMVAP SGARLGPSPH LQALLQDRPH FMHQLSTVDA HAQTPVLQVR 
PLDNPAMISL PPPSAATGVF SLKARPGLPP GINVASLEWV SREPALLCTF PRSGTPRKDS 
NLLAAPQGSY PLLANGVCKW PGCEKVFEEP EEFLKHCQAD HLLDEKGKAQ CLLQREVVQS 
LEQQLELEKE KLGAMQAHLA GKMALAKAPS VASMDKSSCC IVATSTQGSV LPAWSAPREA 
PDGGLFAVRR HLWGSHGNSS FPEFFHNMDY FKYHNMRPPF TYATLIRWAI LEAPERQRTL 
NEIYHWFTRM FAYFRNHPAT WKNAIRHNLS LHKCFVRVES EKGAVWTVDE FEFRKKRSQR 
PNKCSNPCP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.