Details for: Spi1

Gene ID: 20375

Symbol: Spi1

Ensembl ID: ENSMUSG00000002111

Description: Spi-1 proto-oncogene

Associated with

  • Anatomical structure regression
    (GO:0060033)
  • Apoptotic process involved in blood vessel morphogenesis
    (GO:1902262)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Defense response to tumor cell
    (GO:0002357)
  • Dna-binding transcription activator activity
    (GO:0001216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Endothelial to hematopoietic transition
    (GO:0098508)
  • Erythrocyte differentiation
    (GO:0030218)
  • Follicular b cell differentiation
    (GO:0002316)
  • Germinal center b cell differentiation
    (GO:0002314)
  • Granulocyte differentiation
    (GO:0030851)
  • Histone deacetylase binding
    (GO:0042826)
  • Immature b cell differentiation
    (GO:0002327)
  • Interleukin-6-mediated signaling pathway
    (GO:0070102)
  • Lipopolysaccharide-mediated signaling pathway
    (GO:0031663)
  • Lymphocyte differentiation
    (GO:0030098)
  • Lymphoid progenitor cell differentiation
    (GO:0002320)
  • Macrophage differentiation
    (GO:0030225)
  • Molecular adaptor activity
    (GO:0060090)
  • Multicellular organism development
    (GO:0007275)
  • Myeloid dendritic cell differentiation
    (GO:0043011)
  • Myeloid leukocyte differentiation
    (GO:0002573)
  • Negative regulation of adipose tissue development
    (GO:1904178)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of mhc class ii biosynthetic process
    (GO:0045347)
  • Negative regulation of neutrophil degranulation
    (GO:0043314)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of non-canonical nf-kappab signal transduction
    (GO:1901223)
  • Negative regulation of protein localization to chromatin
    (GO:0120186)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nfat protein binding
    (GO:0051525)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Oncogene-induced cell senescence
    (GO:0090402)
  • Pericyte cell differentiation
    (GO:1904238)
  • Positive regulation of antifungal innate immune response
    (GO:1905036)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of microglial cell mediated cytotoxicity
    (GO:1904151)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of myeloid dendritic cell chemotaxis
    (GO:2000529)
  • Positive regulation of p38mapk cascade
    (GO:1900745)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Pro-t cell differentiation
    (GO:0002572)
  • Protein binding
    (GO:0005515)
  • Protein sequestering activity
    (GO:0140311)
  • Regulation of dna-binding transcription factor activity
    (GO:0051090)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of erythrocyte differentiation
    (GO:0045646)
  • Regulation of myeloid progenitor cell differentiation
    (GO:1905453)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stat family protein binding
    (GO:0097677)
  • Trail-activated apoptotic signaling pathway
    (GO:0036462)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription initiation-coupled chromatin remodeling
    (GO:0045815)
  • Transcription regulator complex
    (GO:0005667)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Vasculature development
    (GO:0001944)

Other Information

Genular Protein ID: 528350177

Symbol: SPI1_MOUSE

Name: 31 kDa-transforming protein

UniProtKB Accession Codes:

P17433 Q99L57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2594367

Title: The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias.

PubMed ID: 2594367

PubMed ID: 2180582

Title: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene.

PubMed ID: 2180582

DOI: 10.1016/0092-8674(90)90219-5

PubMed ID: 1985210

Title: The Sfpi-1 proviral integration site of Friend erythroleukemia encodes the ets-related transcription factor Pu.1.

PubMed ID: 1985210

DOI: 10.1128/jvi.65.1.464-467.1991

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7594592

Title: Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).

PubMed ID: 7594592

PubMed ID: 8626664

Title: The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb.

PubMed ID: 8626664

DOI: 10.1074/jbc.271.19.11177

PubMed ID: 17197705

Title: The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.

PubMed ID: 17197705

DOI: 10.1074/jbc.m607613200

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 8079170

Title: Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

PubMed ID: 8079170

DOI: 10.1126/science.8079170

PubMed ID: 8602247

Title: A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex.

PubMed ID: 8602247

DOI: 10.1038/380456a0

Sequence Information:

  • Length: 272
  • Mass: 31349
  • Checksum: 765E9CC2F374EB6E
  • Sequence:
    • MLQACKMEGF SLTAPPSDDL VTYDSELYQR PMHDYYSFVG SDGESHSDHY WDFSAHHVHN 
NEFENFPENH FTELQSVQPP QLQQLYRHME LEQMHVLDTP MVPPHTGLSH QVSYMPRMCF 
PYQTLSPAHQ QSSDEEEGER QSPPLEVSDG EADGLEPGPG LLHGETGSKK KIRLYQFLLD 
LLRSGDMKDS IWWVDKDKGT FQFSSKHKEA LAHRWGIQKG NRKKMTYQKM ARALRNYGKT 
GEVKKVKKKL TYQFSGEVLG RGGLAERRLP PH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.