Details for: Sfrp1

Gene ID: 20377

Symbol: Sfrp1

Ensembl ID: ENSMUSG00000031548

Description: secreted frizzled-related protein 1

Associated with

  • Actin cytoskeleton organization
    (GO:0030036)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Bmp signaling pathway
    (GO:0030509)
  • Bone trabecula formation
    (GO:0060346)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to estrogen stimulus
    (GO:0071391)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to heparin
    (GO:0071504)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular response to x-ray
    (GO:0071481)
  • Convergent extension involved in somitogenesis
    (GO:0090246)
  • Cysteine-type endopeptidase activity
    (GO:0004197)
  • Development of primary male sexual characteristics
    (GO:0046546)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Dorsal/ventral axis specification
    (GO:0009950)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Female gonad development
    (GO:0008585)
  • Frizzled binding
    (GO:0005109)
  • Hematopoietic progenitor cell differentiation
    (GO:0002244)
  • Hematopoietic stem cell differentiation
    (GO:0060218)
  • Hemopoiesis
    (GO:0030097)
  • Heparin binding
    (GO:0008201)
  • Identical protein binding
    (GO:0042802)
  • Male gonad development
    (GO:0008584)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of b cell differentiation
    (GO:0045578)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of bone remodeling
    (GO:0046851)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of fibroblast proliferation
    (GO:0048147)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of jun kinase activity
    (GO:0043508)
  • Negative regulation of ossification
    (GO:0030279)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of osteoblast proliferation
    (GO:0033689)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of peptidyl-tyrosine phosphorylation
    (GO:0050732)
  • Negative regulation of planar cell polarity pathway involved in axis elongation
    (GO:2000041)
  • Negative regulation of wnt signaling pathway
    (GO:0030178)
  • Neural crest cell fate commitment
    (GO:0014034)
  • Neural tube closure
    (GO:0001843)
  • Neural tube development
    (GO:0021915)
  • Non-canonical wnt signaling pathway
    (GO:0035567)
  • Osteoclast differentiation
    (GO:0030316)
  • Planar cell polarity pathway involved in axis elongation
    (GO:0003402)
  • Planar cell polarity pathway involved in neural tube closure
    (GO:0090179)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902043)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of wnt signaling pathway
    (GO:0030177)
  • Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
    (GO:0060527)
  • Protein binding
    (GO:0005515)
  • Regulation of branching involved in prostate gland morphogenesis
    (GO:0060687)
  • Regulation of cell cycle process
    (GO:0010564)
  • Regulation of establishment of planar polarity
    (GO:0090175)
  • Regulation of midbrain dopaminergic neuron differentiation
    (GO:1904956)
  • Regulation of neuron projection development
    (GO:0010975)
  • Regulation of ossification
    (GO:0030278)
  • Response to organic cyclic compound
    (GO:0014070)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Somitogenesis
    (GO:0001756)
  • Stromal-epithelial cell signaling involved in prostate gland development
    (GO:0044345)
  • Substrate adhesion-dependent cell spreading
    (GO:0034446)
  • Ureteric bud development
    (GO:0001657)
  • Wnt-protein binding
    (GO:0017147)
  • Wnt signaling pathway
    (GO:0016055)
  • Wnt signaling pathway, planar cell polarity pathway
    (GO:0060071)
  • Wnt signaling pathway involved in somitogenesis
    (GO:0090244)

Other Information

Genular Protein ID: 3636839226

Symbol: SFRP1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C4U3 O08861 Q505A2 Q8R1J4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 1 GO 100 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 MEROPS 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9096311

Title: A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

PubMed ID: 9096311

DOI: 10.1073/pnas.94.7.2859

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9739103

Title: Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.

PubMed ID: 9739103

DOI: 10.1016/s0925-4773(98)00072-0

PubMed ID: 10640709

Title: Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis.

PubMed ID: 10640709

DOI: 10.1016/s0925-4773(99)00236-1

PubMed ID: 15306229

Title: FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo.

PubMed ID: 15306229

DOI: 10.1016/j.cardiores.2004.05.006

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 27713059

Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.

PubMed ID: 27713059

DOI: 10.1016/j.ydbio.2016.10.001

Sequence Information:

  • Length: 314
  • Mass: 35413
  • Checksum: 3D98A15127DFA421
  • Sequence:
    • MGVGRSARGR GGAASGVLLA LAAALLAAGS ASEYDYVSFQ SDIGSYQSGR FYTKPPQCVD 
IPVDLRLCHN VGYKKMVLPN LLEHETMAEV KQQASSWVPL LNKNCHMGTQ VFLCSLFAPV 
CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF PEGDVCIAMT PPNTTEASKP 
QGTTVCPPCD NELKSEAIIE HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK 
KELKRLVLFL KNGADCPCHQ LDNLSHNFLI MGRKVKSQYL LTAIHKWDKK NKEFKNFMKR 
MKNHECPTFQ SVFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.