Frzb | ENSMUSG00000027004 | NCBI 20378

Details for: Frzb

Gene ID: 20378

Symbol: Frzb

Ensembl ID: ENSMUSG00000027004

Description: frizzled-related protein

Associated with

Canonical wnt signaling pathway
(GO:0060070)
Cell differentiation
(GO:0030154)
Cochlea morphogenesis
(GO:0090103)
Convergent extension involved in organogenesis
(GO:0060029)
Cytoplasm
(GO:0005737)
Epithelial cell development
(GO:0002064)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hepatocyte differentiation
(GO:0070365)
Inner ear morphogenesis
(GO:0042472)
Multicellular organism development
(GO:0007275)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cartilage development
(GO:0061037)
Negative regulation of cell development
(GO:0010721)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of hepatocyte differentiation
(GO:0070367)
Negative regulation of wnt signaling pathway
(GO:0030178)
Neural crest cell differentiation
(GO:0014033)
Non-canonical wnt signaling pathway
(GO:0035567)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of fat cell differentiation
(GO:0045600)
Protein binding
(GO:0005515)
Somite development
(GO:0061053)
Wnt-protein binding
(GO:0017147)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Secreted frizzled-related protein 3

Genular Protein ID: 1865093709

Symbol: SFRP3_MOUSE

Name: Secreted frizzled-related protein 3

UniProtKB Accession Codes:

P97401 O09075 O09093 Q91W58

Database IDs:

Citations:

PubMed ID: 9118218

Title: Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

PubMed ID: 9118218

DOI: 10.1016/s0092-8674(00)81921-2

PubMed ID: 9178261

Title: Fritz: a secreted frizzled-related protein that inhibits Wnt activity.

PubMed ID: 9178261

DOI: 10.1016/s0925-4773(97)00035-x

PubMed ID: 9096311

Title: A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

PubMed ID: 9096311

DOI: 10.1073/pnas.94.7.2859

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19188438

Title: Myocilin is a modulator of Wnt signaling.

PubMed ID: 19188438

DOI: 10.1128/mcb.01274-08

PubMed ID: 11452312

Title: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.

PubMed ID: 11452312

DOI: 10.1038/35083601

Sequence Information:

Length: 323
Mass: 36011
Checksum: 3F1456F8CFC97740
Sequence:

MVCCGPGRML LGWAGLLVLA ALCLLQVPGA QAAACEPVRI PLCKSLPWNM TKMPNHLHHS 
TQANAILAME QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE 
PILIKYRHSW PESLACDELP VYDRGVCISP EAIVTADGAD FPMDSSTGHC RGASSERCKC 
KPVRATQKTY FRNNYNYVIR AKVKEVKMKC HDVTAVVEVK EILKASLVNI PRDTVNLYTT 
SGCLCPPLTV NEEYVIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLGK 
TDASDSTQNQ KSGRNSNPRP ARS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Frzb

Associated with

Other Information

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. PubMed ID: 9118218

Fritz: a secreted frizzled-related protein that inhibits Wnt activity. PubMed ID: 9178261

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. PubMed ID: 9096311

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Myocilin is a modulator of Wnt signaling. PubMed ID: 19188438

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. PubMed ID: 11452312