Genular: Defining Cellular Identity and Function

Details for: Sfrp4

Gene ID: 20379

Symbol: Sfrp4

Ensembl ID: ENSMUSG00000021319

Description: secreted frizzled-related protein 4

Associated with

Bone morphogenesis
(GO:0060349)
Canonical wnt signaling pathway
(GO:0060070)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Multicellular organism development
(GO:0007275)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of non-canonical wnt signaling pathway
(GO:2000051)
Negative regulation of sodium-dependent phosphate transport
(GO:2000119)
Non-canonical wnt signaling pathway
(GO:0035567)
Nucleus
(GO:0005634)
Phosphate ion homeostasis
(GO:0055062)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of epidermal cell differentiation
(GO:0045606)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of keratinocyte apoptotic process
(GO:1902174)
Positive regulation of receptor internalization
(GO:0002092)
Regulation of bmp signaling pathway
(GO:0030510)
Wnt-protein binding
(GO:0017147)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Secreted frizzled-related sequence protein 4

Genular Protein ID: 3914894723

Symbol: SFRP4_MOUSE

Name: Secreted frizzled-related sequence protein 4

UniProtKB Accession Codes:

Q9Z1N6 Q91ZX9

Database IDs:

Citations:

PubMed ID: 10072424

Title: Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.

PubMed ID: 10072424

DOI: 10.1093/hmg/8.4.575

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9096311

Title: A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

PubMed ID: 9096311

DOI: 10.1073/pnas.94.7.2859

PubMed ID: 11485313

Title: Transcriptional activity of the promoter region of rat frizzled-related protein gene.

PubMed ID: 11485313

DOI: 10.1006/bbrc.2001.5349

PubMed ID: 9739103

Title: Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.

PubMed ID: 9739103

DOI: 10.1016/s0925-4773(98)00072-0

PubMed ID: 12960062

Title: Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells.

PubMed ID: 12960062

DOI: 10.1210/en.2003-0048

PubMed ID: 27355534

Title: Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease.

PubMed ID: 27355534

DOI: 10.1056/nejmoa1509342

Sequence Information:

Length: 351
Mass: 40342
Checksum: 6CB0B625920A54FE
Sequence:

MLRSILVALC LWLRLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST QENAILAIEQ 
YEELVDVNCS SVLRFFLCAM YAPICTLEFL HDPIKPCKSV CQRARDDCEP LMKMYNHSWP 
ESLACDELPV YDRGVCISPE AIVTDLPEDV KWIDITPDMM VQERSFDADC KRLSPDRCKC 
KKVKPTLATY LSKNYSYVIH AKIKAVQRSG CNEVTTVVDV KEIFKSLSPI PRTQVPLITN 
SSCQCPHILP HQDVLIMCYE WRSRMMLLEN CLVEKWRDQL SRRSIQWEER LQEQQRTIQD 
KKQIASRTSR TSRSNPPKSK GRPPAPKPAS PKKNIKARSA PKKSNLKKSA S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sfrp4

Associated with

Other Information

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. PubMed ID: 10072424

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. PubMed ID: 9096311

Transcriptional activity of the promoter region of rat frizzled-related protein gene. PubMed ID: 11485313

Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. PubMed ID: 9739103

Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cells. PubMed ID: 12960062

Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. PubMed ID: 27355534