Genular: Defining Cellular Identity and Function

Details for: Sgpl1

Gene ID: 20397

Symbol: Sgpl1

Ensembl ID: ENSMUSG00000020097

Description: sphingosine phosphate lyase 1

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid catabolism
(R-MMU-9845614)
Sphingolipid metabolism
(R-MMU-428157)
Androgen metabolic process
(GO:0008209)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Carbon-carbon lyase activity
(GO:0016830)
Carboxylic acid metabolic process
(GO:0019752)
Ceramide metabolic process
(GO:0006672)
Endoplasmic reticulum
(GO:0005783)
Estrogen metabolic process
(GO:0008210)
Face morphogenesis
(GO:0060325)
Fatty acid metabolic process
(GO:0006631)
Female gonad development
(GO:0008585)
Fibroblast migration
(GO:0010761)
Hemopoiesis
(GO:0030097)
Kidney development
(GO:0001822)
Leydig cell differentiation
(GO:0033327)
Lipid metabolic process
(GO:0006629)
Luteinization
(GO:0001553)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Nitrogen compound metabolic process
(GO:0006807)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Post-embryonic development
(GO:0009791)
Pyridoxal phosphate binding
(GO:0030170)
Regulation of multicellular organism growth
(GO:0040014)
Roof of mouth development
(GO:0060021)
Skeletal system morphogenesis
(GO:0048705)
Spermatogenesis
(GO:0007283)
Sphinganine-1-phosphate aldolase activity
(GO:0008117)
Sphingolipid catabolic process
(GO:0030149)
Sphingolipid metabolic process
(GO:0006665)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

Sphingosine-1-phosphate aldolase

Genular Protein ID: 2127691237

Symbol: SGPL1_MOUSE

Name: Sphingosine-1-phosphate aldolase

UniProtKB Accession Codes:

Q8R0X7 O54955 Q8C942

Database IDs:

Citations:

PubMed ID: 9464245

Title: Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.

PubMed ID: 9464245

DOI: 10.1006/bbrc.1997.7993

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15522238

Title: Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.

PubMed ID: 15522238

DOI: 10.1016/j.bbrc.2004.10.036

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20097939

Title: Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.

PubMed ID: 20097939

DOI: 10.1074/jbc.m109.081489

PubMed ID: 21173151

Title: Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

PubMed ID: 21173151

DOI: 10.1074/jbc.m110.171819

PubMed ID: 28521611

Title: SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.

PubMed ID: 28521611

DOI: 10.1080/15548627.2017.1291471

PubMed ID: 28165339

Title: Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.

PubMed ID: 28165339

DOI: 10.1172/jci89626

PubMed ID: 28165343

Title: Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.

PubMed ID: 28165343

DOI: 10.1172/jci90171

PubMed ID: 28262793

Title: Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.

PubMed ID: 28262793

DOI: 10.1038/srep43575

Sequence Information:

Length: 568
Mass: 63677
Checksum: FA5D52E4E49DF09E
Sequence:

MPGTDLLKLK DFEPYLEILE SYSTKAKNYV NGYCTKYEPW QLIAWSVLCT LLIVWVYELI 
FQPESLWSRF KKKLFKLIRK MPFIGRKIEQ QVSKAKKDLV KNMPFLKVDK DYVKTLPAQG 
MGTAEVLERL KEYSSMDGSW QEGKASGAVY NGEPKLTELL VQAYGEFTWS NPLHPDIFPG 
LRKLEAEIVR MTCSLFNGGP DSCGCVTSGG TESILMACKA YRDLALEKGI KTPEIVAPES 
AHAAFDKAAH YFGMKIVRVA LKKNMEVDVQ AMKRAISRNT AMLVCSTPQF PHGVMDPVPE 
VAKLAVRYKI PLHVDACLGG FLIVFMEKAG YPLEKPFDFR VKGVTSISAD THKYGYAPKG 
SSVVMYSNEK YRTYQFFVGA DWQGGVYASP SIAGSRPGGI IAACWAALMH FGENGYVEAT 
KQIIKTARFL KSELENIKNI FIFGDPQLSV IALGSNDFDI YRLSNMMSAK GWNFNYLQFP 
RSIHFCITLV HTRKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ ATIDRKLVAE 
ISSVFLDCLY TTDPVTQGNQ MNGSPKPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sgpl1

Associated with

Other Information

Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. PubMed ID: 9464245

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol. PubMed ID: 15522238

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. PubMed ID: 20097939

Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. PubMed ID: 21173151

SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. PubMed ID: 28521611

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. PubMed ID: 28165339

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. PubMed ID: 28165343

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. PubMed ID: 28262793