Details for: AK2

Gene ID: 204

Symbol: AK2

Ensembl ID: ENSG00000004455

Description: adenylate kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.4
    Marker Score: 3543.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.1
    Marker Score: 3718
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.95
    Marker Score: 6131.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.92
    Marker Score: 3187
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.88
    Marker Score: 7404
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.88
    Marker Score: 7258
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.88
    Marker Score: 3927.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.86
    Marker Score: 8936
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.84
    Marker Score: 15892
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.84
    Marker Score: 1955
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.82
    Marker Score: 2923
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.8
    Marker Score: 1902
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.79
    Marker Score: 1019
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.76
    Marker Score: 4802
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.75
    Marker Score: 4407
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.71
    Marker Score: 4063
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.7
    Marker Score: 13304
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.7
    Marker Score: 1154
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.7
    Marker Score: 1806
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.69
    Marker Score: 1126
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.66
    Marker Score: 5886.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.65
    Marker Score: 1666
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.64
    Marker Score: 584
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.64
    Marker Score: 2786.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.63
    Marker Score: 2592
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.61
    Marker Score: 1740
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.61
    Marker Score: 2643
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.61
    Marker Score: 2370
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.61
    Marker Score: 3926
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.59
    Marker Score: 1922.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.59
    Marker Score: 449
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.58
    Marker Score: 4700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.58
    Marker Score: 2883
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.57
    Marker Score: 4211
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.55
    Marker Score: 631
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.54
    Marker Score: 812
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.54
    Marker Score: 4192
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.54
    Marker Score: 1213
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.54
    Marker Score: 821
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.52
    Marker Score: 7476.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.52
    Marker Score: 15296.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.51
    Marker Score: 3562.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.51
    Marker Score: 753
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.51
    Marker Score: 11208
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.5
    Marker Score: 2316
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.49
    Marker Score: 2107
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.48
    Marker Score: 1730
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.47
    Marker Score: 51018
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.47
    Marker Score: 714
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.47
    Marker Score: 809
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.47
    Marker Score: 3654
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.46
    Marker Score: 7699
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.46
    Marker Score: 343
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.46
    Marker Score: 2095
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.45
    Marker Score: 5921
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.44
    Marker Score: 9388
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.44
    Marker Score: 1203
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.43
    Marker Score: 6180
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.43
    Marker Score: 1904
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.42
    Marker Score: 1832
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.42
    Marker Score: 550
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.41
    Marker Score: 1326
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.4
    Marker Score: 1320
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.4
    Marker Score: 692
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.4
    Marker Score: 875
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.39
    Marker Score: 3159
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.38
    Marker Score: 18267
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.38
    Marker Score: 1475.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.37
    Marker Score: 15920.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.37
    Marker Score: 1938
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.37
    Marker Score: 674
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.36
    Marker Score: 2368
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.35
    Marker Score: 391
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.34
    Marker Score: 542
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.34
    Marker Score: 8567
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.34
    Marker Score: 974
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.34
    Marker Score: 340
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.32
    Marker Score: 903
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.32
    Marker Score: 882
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.32
    Marker Score: 4875
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.32
    Marker Score: 1335
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.31
    Marker Score: 44505
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.31
    Marker Score: 256
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.31
    Marker Score: 979
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.3
    Marker Score: 945
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.3
    Marker Score: 2961
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.3
    Marker Score: 480
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.3
    Marker Score: 325
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.29
    Marker Score: 8431.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.28
    Marker Score: 1716
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.27
    Marker Score: 702
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.27
    Marker Score: 446
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.27
    Marker Score: 604
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.27
    Marker Score: 1587
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.27
    Marker Score: 406
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.26
    Marker Score: 302
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.25
    Marker Score: 788
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.25
    Marker Score: 471
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.25
    Marker Score: 1112
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.25
    Marker Score: 1459

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Other Information

**Key characteristics:** - AK2 is a serine/threonine kinase. - It is a highly conserved protein with a similar sequence in mammals. - It is expressed in both nuclear and cytoplasmic compartments. - It is a key regulator of cellular metabolism. **Pathways and functions:** - AK2 is involved in multiple pathways, including the adenylate kinase activity, adp biosynthetic process, and amp metabolic process. - It is a key regulator of energy metabolism, as it is involved in the phosphorylation of various substrates involved in energy production. - It also plays a role in cell signaling, as it is a key regulator of cell cycle progression and apoptosis. **Clinical significance:** - Mutations in the AK2 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. - Studies of AK2 have led to the development of new diagnostic tests and therapeutic strategies for these diseases. **Conclusion:** The AK2 gene is a critical regulator of cellular metabolism and cell signaling. Its mutations have a significant impact on human health, contributing to the development of various diseases.

Genular Protein ID: 3158744612

Symbol: KAD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8843353

Title: Cloning and characterization of cDNA for human adenylate kinase 2A.

PubMed ID: 8843353

DOI: 10.1080/15216549600201931

PubMed ID: 9504408

Title: Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues.

PubMed ID: 9504408

DOI: 10.1093/oxfordjournals.jbchem.a021915

PubMed ID: 9434148

Title: cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2.

PubMed ID: 9434148

DOI: 10.1016/s0167-4781(97)00193-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19043417

Title: Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.

PubMed ID: 19043417

DOI: 10.1038/ng.265

PubMed ID: 19043416

Title: Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.

PubMed ID: 19043416

DOI: 10.1038/ng.278

Sequence Information:

  • Length: 239
  • Mass: 26478
  • Checksum: 86FA94F9EE33629F
  • Sequence:
  • MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL 
    GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM LDDLMEKRKE 
    KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EPMKDDITGE PLIRRSDDNE 
    KALKIRLQAY HTQTTPLIEY YRKRGIHSAI DASQTPDVVF ASILAAFSKA TCKDLVMFI

Genular Protein ID: 112587425

Symbol: G3V213_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 133
  • Mass: 14325
  • Checksum: 120BCEE169339A59
  • Sequence:
  • MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL 
    GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM ADSPQEWPFL 
    PRGVQPSKRA HER

Genular Protein ID: 2944593348

Symbol: F8VY04_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 190
  • Mass: 21226
  • Checksum: D91C7E049AA0810E
  • Sequence:
  • MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QVSDEMVVEL IEKNLETPLC KNGFLLDGFP 
    RTVRQAEMLD DLMEKRKEKL DSVIEFSIPD SLLIRRITGR LIHPKSGRSY HEEFNPPKEP 
    MKDDITGEPL IRRSDDNEKA LKIRLQAYHT QTTPLIEYYR KRGIHSAIDA SQTPDVVFAS 
    ILAAFSKATS

Genular Protein ID: 1534397822

Symbol: F8W1A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 232
  • Mass: 25631
  • Checksum: 7FAEE1A97D81D401
  • Sequence:
  • MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL 
    GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM LDDLMEKRKE 
    KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EPMKDDITGE PLIRRSDDNE 
    KALKIRLQAY HTQTTPLIEY YRKRGIHSAI DASQTPDVVF ASILAAFSKA TC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.