Genular: Defining Cellular Identity and Function

Details for: Shc1

Gene ID: 20416

Symbol: Shc1

Ensembl ID: ENSMUSG00000042626

Description: src homology 2 domain-containing transforming protein C1

Associated with

Axon guidance
(R-MMU-422475)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Cytokine signaling in immune system
(R-MMU-1280215)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Developmental biology
(R-MMU-1266738)
Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Erythropoietin activates ras
(R-MMU-9027284)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Fceri mediated mapk activation
(R-MMU-2871796)
G alpha (s) signalling events
(R-MMU-418555)
Gpcr downstream signalling
(R-MMU-388396)
Gper1 signaling
(R-MMU-9634597)
Hemostasis
(R-MMU-109582)
Igf1r signaling cascade
(R-MMU-2428924)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor signalling cascade
(R-MMU-74751)
Integrin signaling
(R-MMU-354192)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-2 signaling
(R-MMU-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin-15 signaling
(R-MMU-8983432)
Interleukin receptor shc signaling
(R-MMU-912526)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Met activates ras signaling
(R-MMU-8851805)
Nervous system development
(R-MMU-9675108)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Raf/map kinase cascade
(R-MMU-5673001)
Ret signaling
(R-MMU-8853659)
Role of lat2/ntal/lab on calcium mobilization
(R-MMU-2730905)
Shc-mediated cascade:fgfr1
(R-MMU-5654688)
Shc-mediated cascade:fgfr2
(R-MMU-5654699)
Shc-mediated cascade:fgfr3
(R-MMU-5654704)
Shc-mediated cascade:fgfr4
(R-MMU-5654719)
Shc-related events triggered by igf1r
(R-MMU-2428933)
Shc1 events in egfr signaling
(R-MMU-180336)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Shc1 events in erbb4 signaling
(R-MMU-1250347)
Signal attenuation
(R-MMU-74749)
Signaling by alk
(R-MMU-201556)
Signaling by csf3 (g-csf)
(R-MMU-9674555)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by erythropoietin
(R-MMU-9006335)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by interleukins
(R-MMU-449147)
Signaling by met
(R-MMU-6806834)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Signalling to erks
(R-MMU-187687)
Signalling to ras
(R-MMU-167044)
Signal transduction
(R-MMU-162582)
Tie2 signaling
(R-MMU-210993)
Actin cytoskeleton organization
(GO:0030036)
Angiogenesis
(GO:0001525)
Ephrin receptor binding
(GO:0046875)
Epidermal growth factor binding
(GO:0048408)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Insulin-like growth factor receptor binding
(GO:0005159)
Insulin receptor binding
(GO:0005158)
Insulin receptor signaling pathway
(GO:0008286)
Negative regulation of angiogenesis
(GO:0016525)
Neuron differentiation
(GO:0030182)
Neuron projection development
(GO:0031175)
Neurotrophin trka receptor binding
(GO:0005168)
Phosphoprotein binding
(GO:0051219)
Phosphotyrosine residue binding
(GO:0001784)
Positive regulation of cell population proliferation
(GO:0008284)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein phosphatase 2a binding
(GO:0051721)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of smooth muscle contraction
(GO:0006940)
Transmembrane receptor protein tyrosine kinase adaptor activity
(GO:0005068)

Other Information

Proteins

SHC-transforming protein 1

Genular Protein ID: 2720305048

Symbol: SHC1_MOUSE

Name: SHC-transforming protein 1

UniProtKB Accession Codes:

P98083 Q3U2Q7 Q8BFY3 Q8K4C6 Q8K4C7

Database IDs:

Citations:

PubMed ID: 7798194

Title: A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

PubMed ID: 7798194

DOI: 10.1016/s0021-9258(18)31593-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11948181

Title: The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter.

PubMed ID: 11948181

DOI: 10.1074/jbc.m200280200

PubMed ID: 8654924

Title: p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

PubMed ID: 8654924

DOI: 10.1101/gad.10.9.1084

PubMed ID: 8643691

Title: The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

PubMed ID: 8643691

DOI: 10.1073/pnas.93.4.1689

PubMed ID: 9165038

Title: Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways.

PubMed ID: 9165038

DOI: 10.1210/endo.138.6.5203

PubMed ID: 9083021

Title: The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis.

PubMed ID: 9083021

DOI: 10.1074/jbc.272.14.8983

PubMed ID: 9099679

Title: Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP.

PubMed ID: 9099679

DOI: 10.1074/jbc.272.16.10396

PubMed ID: 9885561

Title: Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.

PubMed ID: 9885561

DOI: 10.1016/s1097-2765(00)80288-9

PubMed ID: 10395202

Title: Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells.

PubMed ID: 10395202

DOI: 10.1016/s0161-5890(98)00097-2

PubMed ID: 10068665

Title: A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development.

PubMed ID: 10068665

PubMed ID: 10080542

Title: Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.

PubMed ID: 10080542

DOI: 10.1002/jlb.65.3.372

PubMed ID: 11433297

Title: N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.

PubMed ID: 11433297

DOI: 10.1038/35083041

PubMed ID: 12367511

Title: Mechanism of TrkB-mediated hippocampal long-term potentiation.

PubMed ID: 12367511

DOI: 10.1016/s0896-6273(02)00942-x

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 12571362

Title: Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

PubMed ID: 12571362

DOI: 10.1073/pnas.0336359100

PubMed ID: 15467833

Title: CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation.

PubMed ID: 15467833

DOI: 10.1172/jci21786

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 17272725

Title: Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.

PubMed ID: 17272725

DOI: 10.1126/science.1135380

PubMed ID: 19665990

Title: TRIM31 interacts with p52(Shc) and inhibits Src-induced anchorage-independent growth.

PubMed ID: 19665990

DOI: 10.1016/j.bbrc.2009.08.028

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 579
Mass: 62608
Checksum: 99C22E64412B6236
Sequence:

MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS 
FFPRMSNLKL ANPAGGRLGP KGEPGKAAED GEGSAGAALR DSGLLPLLQD MNKLSGGGGR 
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD 
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS 
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV 
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL 
GGVVDMRLRE GAARPTLPSA QMSSHLGATL PIGQHAAGDH EVRKQMLPPP PCPGRELFDD 
PSYVNIQNLD KARQAGGGAG PPNPSLNGSA PRDLFDMKPF EDALRVPPPP QSMSMAEQLQ 
GEPWFHGKLS RREAEALLQL NGDFLVREST TTPGQYVLTG LQSGQPKHLL LVDPEGVVRT 
KDHRFESVSH LISYHMDNHL PIISAGSELC LQQPVDRKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Shc1

Associated with

Other Information

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. PubMed ID: 7798194

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter. PubMed ID: 11948181

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. PubMed ID: 8654924

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. PubMed ID: 8643691

Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. PubMed ID: 9165038

The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. PubMed ID: 9083021

Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP. PubMed ID: 9099679

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. PubMed ID: 9885561

Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells. PubMed ID: 10395202

A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development. PubMed ID: 10068665

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. PubMed ID: 10080542

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. PubMed ID: 11433297

Mechanism of TrkB-mediated hippocampal long-term potentiation. PubMed ID: 12367511

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. PubMed ID: 12925710

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. PubMed ID: 12571362

CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. PubMed ID: 15467833

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. PubMed ID: 17272725

TRIM31 interacts with p52(Shc) and inhibits Src-induced anchorage-independent growth. PubMed ID: 19665990

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337