Genular: Defining Cellular Identity and Function

Details for: Shh

Gene ID: 20423

Symbol: Shh

Ensembl ID: ENSMUSG00000002633

Description: sonic hedgehog

Associated with

Activation of smo
(R-MMU-5635838)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Ligand-receptor interactions
(R-MMU-5632681)
Release of hh-np from the secreting cell
(R-MMU-5362798)
Signaling by hedgehog
(R-MMU-5358351)
Androgen metabolic process
(GO:0008209)
Angiogenesis
(GO:0001525)
Anterior/posterior pattern specification
(GO:0009952)
Axon guidance
(GO:0007411)
Blood coagulation
(GO:0007596)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Calcium ion binding
(GO:0005509)
Cell-cell signaling
(GO:0007267)
Cell fate specification
(GO:0001708)
Cell population proliferation
(GO:0008283)
Central nervous system development
(GO:0007417)
Cholesterol-protein transferase activity
(GO:0140853)
Determination of left/right asymmetry in lateral mesoderm
(GO:0003140)
Determination of left/right symmetry
(GO:0007368)
Digestive tract mesoderm development
(GO:0007502)
Dorsal/ventral pattern formation
(GO:0009953)
Ectoderm development
(GO:0007398)
Embryo development
(GO:0009790)
Endocytosis
(GO:0006897)
Gene expression
(GO:0010467)
Glycosaminoglycan binding
(GO:0005539)
Hair follicle development
(GO:0001942)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Hindgut morphogenesis
(GO:0007442)
Hydrolase activity
(GO:0016787)
Kidney development
(GO:0001822)
Laminin-1 binding
(GO:0043237)
Lymphoid progenitor cell differentiation
(GO:0002320)
Mesenchymal cell proliferation
(GO:0010463)
Metal ion binding
(GO:0046872)
Metanephros development
(GO:0001656)
Multicellular organism development
(GO:0007275)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell migration
(GO:0001755)
Neural tube formation
(GO:0001841)
Neuroblast proliferation
(GO:0007405)
Oligodendrocyte development
(GO:0014003)
Osteoblast development
(GO:0002076)
Patched binding
(GO:0005113)
Pattern specification process
(GO:0007389)
Peptidase activity
(GO:0008233)
Polarity specification of anterior/posterior axis
(GO:0009949)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of skeletal muscle cell proliferation
(GO:0014858)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Proteolysis
(GO:0006508)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Signal transduction
(GO:0007165)
Skeletal muscle cell proliferation
(GO:0014856)
Skeletal muscle tissue development
(GO:0007519)
Smoothened signaling pathway
(GO:0007224)
Striated muscle tissue development
(GO:0014706)
Transferase activity
(GO:0016740)
Vasculature development
(GO:0001944)
Vasculogenesis
(GO:0001570)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

HHG-1

Genular Protein ID: 3523451642

Symbol: SHH_MOUSE

Name: HHG-1

UniProtKB Accession Codes:

Q62226

Database IDs:

Citations:

PubMed ID: 7916661

Title: Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

PubMed ID: 7916661

DOI: 10.1016/0092-8674(93)90627-3

PubMed ID: 7720571

Title: Products, genetic linkage and limb patterning activity of a murine hedgehog gene.

PubMed ID: 7720571

DOI: 10.1242/dev.120.11.3339

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7891723

Title: Proteolytic processing yields two secreted forms of sonic hedgehog.

PubMed ID: 7891723

DOI: 10.1128/mcb.15.4.2294

PubMed ID: 7736596

Title: Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.

PubMed ID: 7736596

DOI: 10.1016/0092-8674(95)90397-6

PubMed ID: 8824192

Title: Cholesterol modification of hedgehog signaling proteins in animal development.

PubMed ID: 8824192

DOI: 10.1126/science.274.5285.255

PubMed ID: 11486055

Title: Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.

PubMed ID: 11486055

DOI: 10.1126/science.1064437

PubMed ID: 11430830

Title: A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

PubMed ID: 11430830

DOI: 10.1016/s1097-2765(01)00271-4

PubMed ID: 14687547

Title: RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways.

PubMed ID: 14687547

DOI: 10.1016/s0896-6273(03)00769-4

PubMed ID: 12679031

Title: The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance.

PubMed ID: 12679031

DOI: 10.1016/s0092-8674(03)00199-5

PubMed ID: 15315762

Title: Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.

PubMed ID: 15315762

DOI: 10.1016/j.cell.2004.07.023

PubMed ID: 15075292

Title: Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.

PubMed ID: 15075292

DOI: 10.1101/gad.1185804

PubMed ID: 16282375

Title: Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.

PubMed ID: 16282375

DOI: 10.1073/pnas.0507848102

PubMed ID: 18081866

Title: Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.

PubMed ID: 18081866

DOI: 10.1111/j.1742-4658.2007.06202.x

PubMed ID: 18477453

Title: Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.

PubMed ID: 18477453

DOI: 10.1016/j.devcel.2008.03.006

PubMed ID: 21357747

Title: Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.

PubMed ID: 21357747

DOI: 10.1083/jcb.201008090

PubMed ID: 22902404

Title: Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand.

PubMed ID: 22902404

DOI: 10.1016/j.celrep.2012.07.010

PubMed ID: 22677548

Title: Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form.

PubMed ID: 22677548

DOI: 10.1101/gad.191866.112

PubMed ID: 23118222

Title: An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions.

PubMed ID: 23118222

DOI: 10.1074/jbc.m112.356667

PubMed ID: 24522195

Title: Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells.

PubMed ID: 24522195

DOI: 10.1242/jcs.137695

PubMed ID: 24863049

Title: Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers.

PubMed ID: 24863049

DOI: 10.1002/dneu.22193

PubMed ID: 7477329

Title: A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog.

PubMed ID: 7477329

DOI: 10.1038/378212a0

PubMed ID: 18794898

Title: The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.

PubMed ID: 18794898

DOI: 10.1038/nature07358

PubMed ID: 19561611

Title: Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

PubMed ID: 19561611

DOI: 10.1038/nsmb.1607

PubMed ID: 20519495

Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

PubMed ID: 20519495

DOI: 10.1074/jbc.m110.131680

Sequence Information:

Length: 437
Mass: 47773
Checksum: D0EB72F08E7860EF
Sequence:

MLLLLARCFL VILASSLLVC PGLACGPGRG FGKRRHPKKL TPLAYKQFIP NVAEKTLGAS 
GRYEGKITRN SERFKELTPN YNPDIIFKDE ENTGADRLMT QRCKDKLNAL AISVMNQWPG 
VKLRVTEGWD EDGHHSEESL HYEGRAVDIT TSDRDRSKYG MLARLAVEAG FDWVYYESKA 
HIHCSVKAEN SVAAKSGGCF PGSATVHLEQ GGTKLVKDLR PGDRVLAADD QGRLLYSDFL 
TFLDRDEGAK KVFYVIETLE PRERLLLTAA HLLFVAPHND SGPTPGPSAL FASRVRPGQR 
VYVVAERGGD RRLLPAAVHS VTLREEEAGA YAPLTAHGTI LINRVLASCY AVIEEHSWAH 
RAFAPFRLAH ALLAALAPAR TDGGGGGSIP AAQSATEARG AEPTAGIHWY SQLLYHIGTW 
LLDSETMHPL GMAVKSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Shh

Associated with

Other Information

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. PubMed ID: 7916661

Products, genetic linkage and limb patterning activity of a murine hedgehog gene. PubMed ID: 7720571

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Proteolytic processing yields two secreted forms of sonic hedgehog. PubMed ID: 7891723

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. PubMed ID: 7736596

Cholesterol modification of hedgehog signaling proteins in animal development. PubMed ID: 8824192

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. PubMed ID: 11486055

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. PubMed ID: 11430830

RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. PubMed ID: 14687547

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. PubMed ID: 12679031

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. PubMed ID: 15315762

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. PubMed ID: 15075292

Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. PubMed ID: 16282375

Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. PubMed ID: 18081866

Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. PubMed ID: 18477453

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. PubMed ID: 21357747

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. PubMed ID: 22902404

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. PubMed ID: 22677548

An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions. PubMed ID: 23118222

Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells. PubMed ID: 24522195

Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers. PubMed ID: 24863049

A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. PubMed ID: 7477329

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. PubMed ID: 18794898

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. PubMed ID: 19561611

All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. PubMed ID: 20519495