Genular: Defining Cellular Identity and Function

Details for: Shmt1

Gene ID: 20425

Symbol: Shmt1

Ensembl ID: ENSMUSG00000020534

Description: serine hydroxymethyltransferase 1 (soluble)

Associated with

Carnitine synthesis
(R-MMU-71262)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of folate and pterines
(R-MMU-196757)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Amino acid binding
(GO:0016597)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to tetrahydrofolate
(GO:1904482)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dtmp biosynthetic process
(GO:0006231)
Folic acid metabolic process
(GO:0046655)
Glycine biosynthetic process
(GO:0006545)
Glycine biosynthetic process from serine
(GO:0019264)
Glycine hydroxymethyltransferase activity
(GO:0004372)
Glycine metabolic process
(GO:0006544)
Identical protein binding
(GO:0042802)
L-allo-threonine aldolase activity
(GO:0008732)
L-serine catabolic process
(GO:0006565)
L-serine metabolic process
(GO:0006563)
Mitochondrion
(GO:0005739)
Mrna 5'-utr binding
(GO:0048027)
Mrna regulatory element binding translation repressor activity
(GO:0000900)
Negative regulation of translation
(GO:0017148)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
One-carbon metabolic process
(GO:0006730)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Purine nucleobase biosynthetic process
(GO:0009113)
Pyridoxal phosphate binding
(GO:0030170)
Serine binding
(GO:0070905)
Small molecule binding
(GO:0036094)
Tetrahydrofolate interconversion
(GO:0035999)
Tetrahydrofolate metabolic process
(GO:0046653)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine hydroxymethyltransferase, cytosolic

Genular Protein ID: 1797895313

Symbol: GLYC_MOUSE

Name: Serine hydroxymethyltransferase, cytosolic

UniProtKB Accession Codes:

P50431 Q64508 Q8R0X9

Database IDs:

Citations:

PubMed ID: 11063567

Title: Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers.

PubMed ID: 11063567

DOI: 10.1021/bi000635a

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8863732

Title: Isolation of retinoic acid-repressed genes from P19 embryonal carcinoma cells.

PubMed ID: 8863732

DOI: 10.1016/0378-1119(96)00391-5

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 478
Mass: 52601
Checksum: 780C764C5AA3CEA3
Sequence:

MADRDATLWA SHEKMLSQPL KDSDAEVYSI IKKESNRQRV GLELIASENF ASRAVLEALG 
SCLNNKYSEG YPGQRYYGGT EFIDELEMLC QKRALQAYHL DPQCWGVNVQ PYSGSPANFA 
VYTALVEPHG RIMGLDLPDG GHLTHGFMTD KKKISATSIF FESMPYKVYP ETGYINYDQL 
EENASLFHPK LIIAGTSCYS RNLDYARLRK IADDNGAYLM ADMAHISGLV AAGVVPSPFE 
HCHVVTTTTH KTLRGCRAGM IFYRKGVRSV DPKTGKETYY ELESLINSAV FPGLQGGPHN 
HAIAGVAVAL KQAMTTEFKI YQLQVLANCR ALSDALTELG YKIVTGGSDN HLILMDLRSK 
GTDGGRAEKV LEACSIACNK NTCPGDKSAL RPSGLRLGTP ALTSRGLLEE DFQKVAHFIH 
RGIELTLQIQ SHMATKATLK EFKEKLAGDE KIQSAVATLR EEVENFASNF SLPGLPDF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Shmt1

Associated with

Other Information

Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers. PubMed ID: 11063567

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334