Genular: Defining Cellular Identity and Function

Details for: Siah1a

Gene ID: 20437

Symbol: Siah1a

Ensembl ID: ENSMUSG00000036840

Description: siah E3 ubiquitin protein ligase 1A

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Immune system
(R-MMU-168256)
Apoptotic process
(GO:0006915)
Beta-catenin destruction complex
(GO:0030877)
Canonical wnt signaling pathway
(GO:0060070)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Early endosome
(GO:0005769)
Identical protein binding
(GO:0042802)
Male meiosis i
(GO:0007141)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Neuron apoptotic process
(GO:0051402)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Post-embryonic development
(GO:0009791)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein destabilization
(GO:0031648)
Protein homodimerization activity
(GO:0042803)
Regulation of multicellular organism growth
(GO:0040014)
Scf ubiquitin ligase complex
(GO:0019005)
Spermatogenesis
(GO:0007283)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase SIAH1A

Genular Protein ID: 4282890973

Symbol: SIA1A_MOUSE

Name: E3 ubiquitin-protein ligase SIAH1A

UniProtKB Accession Codes:

P61092 Q06984

Database IDs:

Citations:

PubMed ID: 8404535

Title: Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).

PubMed ID: 8404535

DOI: 10.1242/dev.117.4.1333

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10681424

Title: Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.

PubMed ID: 10681424

DOI: 10.1073/pnas.040378897

PubMed ID: 12646221

Title: Inhibition of ubiquitin ligase Siah-1A by disabled-1.

PubMed ID: 12646221

DOI: 10.1016/s0006-291x(03)00247-x

PubMed ID: 11884614

Title: The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.

PubMed ID: 11884614

DOI: 10.1128/mcb.22.7.2294-2303.2002

PubMed ID: 12417719

Title: Normal p53 function in primary cells deficient for Siah genes.

PubMed ID: 12417719

DOI: 10.1128/mcb.22.23.8155-8164.2002

PubMed ID: 24809345

Title: Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

PubMed ID: 24809345

DOI: 10.1371/journal.pgen.1004348

PubMed ID: 28546513

Title: The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation.

PubMed ID: 28546513

DOI: 10.1101/gad.300053.117

PubMed ID: 11742346

Title: Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.

PubMed ID: 11742346

DOI: 10.1038/nsb743

PubMed ID: 16615911

Title: Elucidation of the substrate binding site of Siah ubiquitin ligase.

PubMed ID: 16615911

DOI: 10.1016/j.str.2005.12.013

Sequence Information:

Length: 282
Mass: 31137
Checksum: 852EADC5DD4A4FFA
Sequence:

MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL 
VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKAEHEEL 
CEFRPYSCPC PGASCKWQGS LDAVMPHLMH QHKSITTLQG EDIVFLATDI NLPGAVDWVM 
MQSCFGFHFM LVLEKQEKYD GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP 
RSIHEGIATA IMNSDCLVFD TSIAQLFAEN GNLGINVTIS MC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Siah1a

Associated with

Other Information

Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina). PubMed ID: 8404535

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. PubMed ID: 10681424

Inhibition of ubiquitin ligase Siah-1A by disabled-1. PubMed ID: 12646221

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. PubMed ID: 11884614

Normal p53 function in primary cells deficient for Siah genes. PubMed ID: 12417719

Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PubMed ID: 24809345

The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling through mediating Wnt-induced Axin degradation. PubMed ID: 28546513

Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. PubMed ID: 11742346

Elucidation of the substrate binding site of Siah ubiquitin ligase. PubMed ID: 16615911