Details for: Siah2

Gene ID: 20439

Symbol: Siah2

Ensembl ID: ENSMUSG00000036432

Description: siah E3 ubiquitin protein ligase 2

Associated with

Other Information

Genular Protein ID: 1971642231

Symbol: SIAH2_MOUSE

Name: E3 ubiquitin-protein ligase SIAH2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8404535

Title: Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).

PubMed ID: 8404535

DOI: 10.1242/dev.117.4.1333

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7895278

Title: Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis.

PubMed ID: 7895278

DOI: 10.1007/bf00318499

PubMed ID: 9637679

Title: Proteasomal regulation of nuclear receptor corepressor-mediated repression.

PubMed ID: 9637679

DOI: 10.1101/gad.12.12.1775

PubMed ID: 10681424

Title: Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.

PubMed ID: 10681424

DOI: 10.1073/pnas.040378897

PubMed ID: 11257006

Title: Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis.

PubMed ID: 11257006

DOI: 10.1242/jcs.114.7.1409

PubMed ID: 12417719

Title: Normal p53 function in primary cells deficient for Siah genes.

PubMed ID: 12417719

DOI: 10.1128/mcb.22.23.8155-8164.2002

PubMed ID: 14645526

Title: Generation and analysis of Siah2 mutant mice.

PubMed ID: 14645526

DOI: 10.1128/mcb.23.24.9150-9161.2003

PubMed ID: 14645235

Title: The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome.

PubMed ID: 14645235

DOI: 10.1074/jbc.m306407200

PubMed ID: 17003045

Title: Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.

PubMed ID: 17003045

DOI: 10.1074/jbc.m606568200

PubMed ID: 24809345

Title: Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

PubMed ID: 24809345

DOI: 10.1371/journal.pgen.1004348

PubMed ID: 26070566

Title: Exchange factor TBL1 and arginine methyltransferase PRMT6 cooperate in protecting G protein pathway suppressor 2 (GPS2) from proteasomal degradation.

PubMed ID: 26070566

DOI: 10.1074/jbc.m115.637660

PubMed ID: 26392558

Title: Ubiquitin ligase Siah2 regulates RevErbalpha degradation and the mammalian circadian clock.

PubMed ID: 26392558

DOI: 10.1073/pnas.1501204112

Sequence Information:

  • Length: 325
  • Mass: 34758
  • Checksum: 1CB73AD3B4C9982F
  • Sequence:
  • MSRPSSTGPS ANKPCSKQPP PPQTPHAPSP AAPPAAATIS AAGPGSSAVP AAAAVISGPG 
    AGGGADPVSP QHHELTSLFE CPVCFDYVLP PILQCQAGHL VCNQCRQKLS CCPTCRGALT 
    PSIRNLAMEK VASAVLFPCK YATTGCSLTL HHTEKPEHED ICEYRPYSCP CPGASCKWQG 
    SLEAVMSHLM HAHKSITTLQ GEDIVFLATD INLPGAVDWV MMQSCFGHHF MLVLEKQEKY 
    EGHQQFFAIV LLIGTRKQAE NFAYRLELNG NRRRLTWEAT PRSIHDGVAA AIMNSDCLVF 
    DTAIAHLFAD NGNLGINVTI STCCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.