Genular: Defining Cellular Identity and Function

Details for: Ptk6

Gene ID: 20459

Symbol: Ptk6

Ensembl ID: ENSMUSG00000038751

Description: PTK6 protein tyrosine kinase 6

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Ptk6 activates stat3
(R-MMU-8849474)
Ptk6 down-regulation
(R-MMU-8849472)
Ptk6 promotes hif1a stabilization
(R-MMU-8857538)
Ptk6 regulates cell cycle
(R-MMU-8849470)
Ptk6 regulates proteins involved in rna processing
(R-MMU-8849468)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-MMU-8849471)
Ptk6 regulates rtks and their effectors akt1 and dok1
(R-MMU-8849469)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Signaling by erbb2
(R-MMU-1227986)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cell projection
(GO:0042995)
Cellular response to retinoic acid
(GO:0071300)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Intestinal epithelial cell differentiation
(GO:0060575)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Negative regulation of growth
(GO:0045926)
Negative regulation of protein tyrosine kinase activity
(GO:0061099)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of neuron projection development
(GO:0010976)
Protein autophosphorylation
(GO:0046777)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Ruffle
(GO:0001726)
Signaling receptor binding
(GO:0005102)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Protein-tyrosine kinase 6

Genular Protein ID: 2777448220

Symbol: PTK6_MOUSE

Name: Protein-tyrosine kinase 6

UniProtKB Accession Codes:

Q64434

Database IDs:

Citations:

PubMed ID: 7838533

Title: A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract.

PubMed ID: 7838533

PubMed ID: 9405638

Title: A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation.

PubMed ID: 9405638

DOI: 10.1073/pnas.94.26.14477

PubMed ID: 10430081

Title: BRK/Sik expression in the gastrointestinal tract and in colon tumors.

PubMed ID: 10430081

PubMed ID: 10913193

Title: Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability.

PubMed ID: 10913193

DOI: 10.1128/mcb.20.16.6114-6126.2000

PubMed ID: 12833144

Title: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells.

PubMed ID: 12833144

DOI: 10.1038/sj.onc.1206465

PubMed ID: 15471878

Title: The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

PubMed ID: 15471878

DOI: 10.1074/jbc.m409579200

PubMed ID: 16782882

Title: Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.

PubMed ID: 16782882

DOI: 10.1128/mcb.01901-05

PubMed ID: 19501589

Title: Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.

PubMed ID: 19501589

DOI: 10.1053/j.gastro.2009.05.054

Sequence Information:

Length: 451
Mass: 51972
Checksum: 8FBEC26025498DEC
Sequence:

MVSWDKAHLG PKYVGLWDFK ARTDEELSFQ AGDLLHVTKK EELWWWATLL DAEGKALAEG 
YVPHNYLAEK ETVESEPWFF GCISRSEAMH RLQAEDNSKG AFLIRVSQKP GADYVLSVRD 
AQAVRHYRIW KNNEGRLHLN EAVSFSNLSE LVDYHKTQSL SHGLQLSMPC WKHKTEPLPH 
WDDWERPREE FTLCKKLGAG YFGEVFEALW KGQVHVAVKV ISRDNLLHQH TFQAEIQAMK 
KLRHKHILSL YAVATAGDPV YIITELMPKG NLLQLLRDSD EKALPILELV DFASQVAEGM 
CYLESQNYIH RDLAARNVLV TENNLCKVGD FGLARLVKED IYLSHEHNVP YKWTAPEALS 
RGHYSIKSDV WSFGVLLHEI FSRGQMPYPG MSNHETFLRV DAGYRMPCPL ECPPNIHKLM 
LSCWSRDPKQ RPCFKDLCEK LTGITRYENL V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptk6

Associated with

Other Information

A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract. PubMed ID: 7838533

A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation. PubMed ID: 9405638

BRK/Sik expression in the gastrointestinal tract and in colon tumors. PubMed ID: 10430081

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. PubMed ID: 10913193

Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. PubMed ID: 12833144

The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. PubMed ID: 15471878

Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. PubMed ID: 16782882

Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis. PubMed ID: 19501589