Details for: Sin3a
Associated with
Other Information
Genular Protein ID: 2287331885
Symbol: SIN3A_MOUSE
Name: Paired amphipathic helix protein Sin3a
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7601471
Title: A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3.
PubMed ID: 7601471
PubMed ID: 8649810
Title: Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
PubMed ID: 8649810
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7889570
Title: Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.
PubMed ID: 7889570
PubMed ID: 8521822
Title: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.
PubMed ID: 8521822
PubMed ID: 8617250
PubMed ID: 9139820
Title: A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
PubMed ID: 9139820
DOI: 10.1038/387043a0
PubMed ID: 9702189
Title: SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
PubMed ID: 9702189
PubMed ID: 10950960
Title: The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A.
PubMed ID: 10950960
PubMed ID: 10734093
Title: The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
PubMed ID: 10734093
PubMed ID: 11390640
Title: Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex.
PubMed ID: 11390640
PubMed ID: 12198165
Title: The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription.
PubMed ID: 12198165
DOI: 10.1093/emboj/cdf460
PubMed ID: 11909966
Title: Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.
PubMed ID: 11909966
PubMed ID: 11882901
Title: Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
PubMed ID: 11882901
DOI: 10.1038/416099a
PubMed ID: 12130660
Title: Tissue-specific regulation of retinal and pituitary precursor cell proliferation.
PubMed ID: 12130660
PubMed ID: 12398767
Title: An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.
PubMed ID: 12398767
DOI: 10.1042/bj20020854
PubMed ID: 15345747
Title: Phosphoproteomic analysis of the developing mouse brain.
PubMed ID: 15345747
PubMed ID: 15774581
Title: Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
PubMed ID: 15774581
PubMed ID: 16805913
Title: Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex.
PubMed ID: 16805913
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 19144721
Title: Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.
PubMed ID: 19144721
DOI: 10.1242/dev.029769
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 21454521
Title: The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.
PubMed ID: 21454521
PubMed ID: 21490601
Title: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.
PubMed ID: 21490601
DOI: 10.1038/nature10066
PubMed ID: 21680841
Title: A molecular mechanism for circadian clock negative feedback.
PubMed ID: 21680841
PubMed ID: 22476904
Title: Sin3 interacts with Foxk1 and regulates myogenic progenitors.
PubMed ID: 22476904
PubMed ID: 23806337
Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
PubMed ID: 23806337
PubMed ID: 25402684
Title: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs.
PubMed ID: 25402684
DOI: 10.1038/ncb3062
PubMed ID: 27399968
Title: Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity.
PubMed ID: 27399968
DOI: 10.1038/ng.3619
PubMed ID: 28554894
Title: Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
PubMed ID: 28554894
PubMed ID: 11106735
Title: Solution structure of the interacting domains of the Mad-Sin3 complex: implications for recruitment of a chromatin-modifying complex.
PubMed ID: 11106735
Sequence Information:
- Length: 1274
- Mass: 145088
- Checksum: 80FE378F62ED7CB3
- Sequence:
MKRRLDDQES PVYAAQQRRI PGSTEAFSHQ HRVLAPAPPV YEAVSETMQS ATGIQYSVAP NYQVSAVPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ SHAHPAPPVA PVQGQQQFQR LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI MKEFKSQSID TPGVISRVSQ LFKGHPDLIM GFNTFLPPGY KIEVQTNDMV NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SSQSAPTPAQ PAPQPTAAKV SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT PALTEQEVYA QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV RNDHGGTVKK PQLNNKPQRP SQNGCQIRRH SGTGATPPVK KKPKLMSLKE SSMADASKHG VGTESLFFDK VRKALRSAEA YENFLRCLVI FNQEVISRAE LVQLVSPFLG KFPELFNWFK NFLGYKESVH LESFPKERAT EGIAMEIDYA SCKRLGSSYR ALPKSYQQPK CTGRTPLCKE VLNDTWVSFP SWSEDSTFVS SKKTQYEEHI YRCEDERFEL DVVLETNLAT IRVLEAIQKK LSRLSAEEQA KFRLDNTLGG TSEVIHRKAL QRIYADKAAD IIDGLRKNPS IAVPIVLKRL KMKEEEWREA QRGFNKVWRE QNEKYYLKSL DHQGINFKQN DTKVLRSKSL LNEIESIYDE RQEQATEENA GVPVGPHLSL AYEDKQILED AAALIIHHVK RQTGIQKEDK YKIKQIMHHF IPDLLFAQRG DLSDVEEEEE EEMDVDEATG APKKHNGVGG SPPKSKLLFS NTAAQKLRGM DEVYNLFYVN NNWYIFMRLH QILCLRLLRI CSQAERQIEE ENREREWERE VLGIKRDKSD SPAIQLRLKE PMDVDVEDYY PAFLDMVRSL LDGNIDSSQY EDSLREMFTI HAYIAFTMDK LIQSIVRQLQ HIVSDEVCVQ VTDLYLAENN NGATGGQLNS QTSRSLLESA YQRKAEQLMS DENCFKLMFI QSQGQVQLTV ELLDTEEENS DDPVEAERWS DYVERYMSSD TTSPELREHL AQKPVFLPRN LRRIRKCQRG REQQEKEGKE GNSKKTMENV ESLDKLECRF KLNSYKMVYV IKSEDYMYRR TALLRAHQSH ERVSKRLHQR FQAWVDKWTK EHVPREMAAE TSKWLMGEGL EGLVPCTTTC DTETLHFVSI NKYRVKYGTV FKAP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.