Genular: Defining Cellular Identity and Function

Details for: Six1

Gene ID: 20471

Symbol: Six1

Ensembl ID: ENSMUSG00000051367

Description: sine oculis-related homeobox 1

Associated with

Anatomical structure development
(GO:0048856)
Aorta morphogenesis
(GO:0035909)
Apoptotic process
(GO:0006915)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cellular response to 3,3',5-triiodo-l-thyronine
(GO:1905243)
Chromatin binding
(GO:0003682)
Cochlea morphogenesis
(GO:0090103)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Embryonic skeletal system morphogenesis
(GO:0048704)
Endothelin receptor signaling pathway
(GO:0086100)
Epithelial cell differentiation
(GO:0030855)
Facial nerve morphogenesis
(GO:0021610)
Fungiform papilla morphogenesis
(GO:0061197)
Gene expression
(GO:0010467)
Generation of neurons
(GO:0048699)
Inner ear development
(GO:0048839)
Inner ear morphogenesis
(GO:0042472)
Kidney development
(GO:0001822)
Mesenchymal cell proliferation involved in ureter development
(GO:0072198)
Mesonephric tubule formation
(GO:0072172)
Metanephric mesenchyme development
(GO:0072075)
Middle ear morphogenesis
(GO:0042474)
Multicellular organism development
(GO:0007275)
Myoblast migration
(GO:0051451)
Myoblast proliferation
(GO:0051450)
Myotome development
(GO:0061055)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell differentiation
(GO:0014033)
Neurogenesis
(GO:0022008)
Neuron fate specification
(GO:0048665)
Notch signaling pathway
(GO:0007219)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory placode formation
(GO:0030910)
Organ induction
(GO:0001759)
Otic vesicle development
(GO:0071599)
Outflow tract morphogenesis
(GO:0003151)
Pattern specification process
(GO:0007389)
Pharyngeal system development
(GO:0060037)
Positive regulation of branching involved in ureteric bud morphogenesis
(GO:0090190)
Positive regulation of brown fat cell differentiation
(GO:0090336)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mesenchymal cell proliferation involved in ureter development
(GO:2000729)
Positive regulation of myoblast proliferation
(GO:2000288)
Positive regulation of secondary heart field cardioblast proliferation
(GO:0072513)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of ureteric bud formation
(GO:0072107)
Protein binding
(GO:0005515)
Protein localization to nucleus
(GO:0034504)
Regulation of branch elongation involved in ureteric bud branching
(GO:0072095)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial cell proliferation
(GO:0050678)
Regulation of gene expression
(GO:0010468)
Regulation of neuron differentiation
(GO:0045664)
Regulation of protein localization
(GO:0032880)
Regulation of skeletal muscle cell differentiation
(GO:2001014)
Regulation of skeletal muscle cell proliferation
(GO:0014857)
Regulation of skeletal muscle satellite cell proliferation
(GO:0014842)
Regulation of synaptic assembly at neuromuscular junction
(GO:0008582)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sensory perception of sound
(GO:0007605)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle fiber development
(GO:0048741)
Skeletal muscle tissue development
(GO:0007519)
Skeletal system morphogenesis
(GO:0048705)
Specification of segmental identity, maxillary segment
(GO:0007382)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Tongue development
(GO:0043586)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription regulator complex
(GO:0005667)
Trigeminal ganglion development
(GO:0061551)
Ureteric bud development
(GO:0001657)
Ureter smooth muscle cell differentiation
(GO:0072193)

Other Information

Proteins

Homeobox protein SIX1
Q8BSP4_MOUSE

Genular Protein ID: 2543070870

Symbol: SIX1_MOUSE

Name: Homeobox protein SIX1

UniProtKB Accession Codes:

Q62231 Q8CIL7

Database IDs:

Citations:

PubMed ID: 7720577

Title: Homeobox genes and connective tissue patterning.

PubMed ID: 7720577

DOI: 10.1242/dev.121.3.693

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11978764

Title: Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.

PubMed ID: 11978764

DOI: 10.1093/hmg/11.9.1045

PubMed ID: 9826681

Title: Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.

PubMed ID: 9826681

DOI: 10.1073/pnas.95.24.14220

PubMed ID: 12215533

Title: Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.

PubMed ID: 12215533

DOI: 10.1128/mcb.22.19.6759-6766.2002

PubMed ID: 12668636

Title: Altered myogenesis in Six1-deficient mice.

PubMed ID: 12668636

DOI: 10.1242/dev.00440

PubMed ID: 12783782

Title: Six1 is required for the early organogenesis of mammalian kidney.

PubMed ID: 12783782

DOI: 10.1242/dev.00536

PubMed ID: 12834866

Title: Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice.

PubMed ID: 12834866

DOI: 10.1016/s0925-4773(03)00065-0

PubMed ID: 14628042

Title: Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis.

PubMed ID: 14628042

DOI: 10.1038/nature02083

PubMed ID: 14695375

Title: Six1 controls patterning of the mouse otic vesicle.

PubMed ID: 14695375

DOI: 10.1242/dev.00943

PubMed ID: 15141091

Title: SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes.

PubMed ID: 15141091

DOI: 10.1073/pnas.0308475101

PubMed ID: 16488997

Title: The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis.

PubMed ID: 16488997

DOI: 10.1158/0008-5472.can-05-2360

PubMed ID: 21884692

Title: Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.

PubMed ID: 21884692

DOI: 10.1016/j.ydbio.2011.08.010

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

Sequence Information:

Length: 284
Mass: 32210
Checksum: 4A6F88000FB9F8EB
Sequence:

MSMLPSFGFT QEQVACVCEV LQQGGNLERL GRFLWSLPAC DHLHKNESVL KAKAVVAFHR 
GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT 
IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 
AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQSNMGH 
ARSSNYSLPG LTASQPSHGL QAHQHQLQDS LLGPLTSSLV DLGS

Genular Protein ID: 2216325259

Symbol: Q8BSP4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BSP4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 284
Mass: 32225
Checksum: 4A6F83D90FB9FFC2
Sequence:

MSMLPSFGFT QEQVACVCEV LQQGGNLERQ GRFLWSLPAC DHLHKNESVL KAKAVVAFHR 
GNFRELYKIL ESHQFSPHNH PKLQQLWLKA HYVEAEKLRG RPLGAVGKYR VRRKFPLPRT 
IWDGEETSYC FKEKSRGVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 
AAEAKERENT ENNNSSSNKQ NQLSPLEGGK PLMSSSEEEF SPPQSPDQNS VLLLQSNMGH 
ARSSNYSLPG LTASQPSHGL QAHQHQLQDS LLGPLTSSLV DLGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Six1

Associated with

Other Information

Homeobox genes and connective tissue patterning. PubMed ID: 7720577

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1. PubMed ID: 11978764

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site. PubMed ID: 9826681

Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. PubMed ID: 12215533

Altered myogenesis in Six1-deficient mice. PubMed ID: 12668636

Six1 is required for the early organogenesis of mammalian kidney. PubMed ID: 12783782

Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. PubMed ID: 12834866

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. PubMed ID: 14628042

Six1 controls patterning of the mouse otic vesicle. PubMed ID: 14695375

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. PubMed ID: 15141091

The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. PubMed ID: 16488997

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. PubMed ID: 21884692

Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PubMed ID: 27923061

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073