Details for: Six2

Gene ID: 20472

Symbol: Six2

Ensembl ID: ENSMUSG00000024134

Description: sine oculis-related homeobox 2

Associated with

  • Anterior/posterior axis specification
    (GO:0009948)
  • Cell migration
    (GO:0016477)
  • Cell population proliferation
    (GO:0008283)
  • Chondrocyte differentiation
    (GO:0002062)
  • Condensed mesenchymal cell proliferation
    (GO:0072137)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic digestive tract morphogenesis
    (GO:0048557)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Epithelial cell differentiation
    (GO:0030855)
  • Kidney development
    (GO:0001822)
  • Mesenchymal cell differentiation involved in kidney development
    (GO:0072161)
  • Mesenchymal stem cell maintenance involved in nephron morphogenesis
    (GO:0072038)
  • Mesenchymal stem cell proliferation
    (GO:0097168)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Mesodermal cell fate specification
    (GO:0007501)
  • Metanephros development
    (GO:0001656)
  • Middle ear morphogenesis
    (GO:0042474)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of epithelial cell differentiation
    (GO:0030857)
  • Nephron development
    (GO:0072006)
  • Nephron morphogenesis
    (GO:0072028)
  • Nucleus
    (GO:0005634)
  • Positive regulation of chondrocyte proliferation
    (GO:1902732)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein import into nucleus
    (GO:0006606)
  • Regulation of branching involved in ureteric bud morphogenesis
    (GO:0090189)
  • Regulation of chondrocyte differentiation
    (GO:0032330)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of ossification
    (GO:0030278)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription factor binding
    (GO:0008134)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 9408089

Symbol: SIX2_MOUSE

Name: Homeobox protein SIX2

UniProtKB Accession Codes:

Q62232 P70179

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 37 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7720577

Title: Homeobox genes and connective tissue patterning.

PubMed ID: 7720577

DOI: 10.1242/dev.121.3.693

PubMed ID: 8814301

Title: Identification and expression of Six family genes in mouse retina.

PubMed ID: 8814301

DOI: 10.1016/0014-5793(96)00899-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11734542

Title: Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.

PubMed ID: 11734542

DOI: 10.1093/hmg/10.24.2775

PubMed ID: 12215533

Title: Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.

PubMed ID: 12215533

DOI: 10.1128/mcb.22.19.6759-6766.2002

PubMed ID: 17036046

Title: Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney.

PubMed ID: 17036046

DOI: 10.1038/sj.emboj.7601381

PubMed ID: 18682239

Title: Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.

PubMed ID: 18682239

DOI: 10.1016/j.stem.2008.05.020

PubMed ID: 18321982

Title: Six2 functions redundantly immediately downstream of Hoxa2.

PubMed ID: 18321982

DOI: 10.1242/dev.017624

PubMed ID: 19660448

Title: Six2 activity is required for the formation of the mammalian pyloric sphincter.

PubMed ID: 19660448

DOI: 10.1016/j.ydbio.2009.07.039

PubMed ID: 19716816

Title: Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.

PubMed ID: 19716816

DOI: 10.1016/j.ydbio.2009.08.020

PubMed ID: 20515681

Title: Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.

PubMed ID: 20515681

DOI: 10.1016/j.ydbio.2010.05.509

PubMed ID: 21350016

Title: Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

PubMed ID: 21350016

DOI: 10.1242/dev.057646

PubMed ID: 22902740

Title: Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.

PubMed ID: 22902740

DOI: 10.1016/j.devcel.2012.07.008

PubMed ID: 24598167

Title: Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.

PubMed ID: 24598167

DOI: 10.1242/dev.103283

Sequence Information:

  • Length: 296
  • Mass: 32718
  • Checksum: 0FFAB002014D8E60
  • Sequence:
    • MSMLPTFGFT QEQVACVCEV LQQGGNIERL GRFLWSLPAC EHLHKNESVL KAKAVVAFHR 
GNFRELYKIL ESHQFSPHNH AKLQQLWLKA HYIEAEKLRG RPLGAVGKYR VRRKFPLPRS 
IWDGEETSYC FKEKSRSVLR EWYAHNPYPS PREKRELAEA TGLTTTQVSN WFKNRRQRDR 
AAEAKERENS ENSNSSSHNP LASSLNGSGK SVLGSSEDEK TPSGTPDHSS SSPALLLSPP 
PPPGLPSLHS LGHPPGPSAV PVPVPGGGGA DPLQHHHSLQ DSILNPMSAN LVDLGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.