Details for: Six3
Associated with
Other Information
Genular Protein ID: 2479544318
Symbol: SIX3_MOUSE
Name: Homeobox protein SIX3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8575305
Title: Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.
PubMed ID: 8575305
PubMed ID: 8814301
Title: Identification and expression of Six family genes in mouse retina.
PubMed ID: 8814301
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11458394
Title: Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.
PubMed ID: 11458394
DOI: 10.1002/dvdy.1148
PubMed ID: 11139622
Title: Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.
PubMed ID: 11139622
DOI: 10.1093/nar/29.2.515
PubMed ID: 12050133
Title: Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.
PubMed ID: 12050133
PubMed ID: 12163408
Title: Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.
PubMed ID: 12163408
PubMed ID: 12072567
Title: Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.
PubMed ID: 12072567
PubMed ID: 12569128
Title: Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
PubMed ID: 12569128
DOI: 10.1101/gad.1059403
PubMed ID: 16024294
Title: Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction.
PubMed ID: 16024294
PubMed ID: 17066077
Title: Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.
PubMed ID: 17066077
PubMed ID: 17666527
Title: Repression of Six3 by a corepressor regulates rhodopsin expression.
PubMed ID: 17666527
PubMed ID: 17576749
Title: Six3 controls the neural progenitor status in the murine CNS.
PubMed ID: 17576749
PubMed ID: 18094027
Title: Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
PubMed ID: 18094027
DOI: 10.1242/dev.010082
PubMed ID: 18775421
Title: Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.
PubMed ID: 18775421
PubMed ID: 18694563
Title: Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.
PubMed ID: 18694563
PubMed ID: 19606496
Title: EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.
PubMed ID: 19606496
DOI: 10.1002/humu.21094
PubMed ID: 20682799
Title: Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor.
PubMed ID: 20682799
PubMed ID: 20890044
Title: Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.
PubMed ID: 20890044
DOI: 10.1172/jci43219
PubMed ID: 22071110
PubMed ID: 23792023
Title: Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.
PubMed ID: 23792023
Sequence Information:
- Length: 333
- Mass: 35593
- Checksum: 1AD7D3C4388043B9
- Sequence:
MVFRSPLDLY SSHFLLPNFA DSHHCSLLLA SSGGGSGASG GGGGAGGGGG GNRAGGGGAG GAGGGSGGGG SRAPPEELSM FQLPTLNFSP EQVASVCETL EETGDIERLG RFLWSLPVAP GACEAINKHE SILRARAVVA FHTGNFRDLY HILENHKFTK ESHGKLQAMW LEAHYQEAEK LRGRPLGPVD KYRVRKKFPL PRTIWDGEQK THCFKERTRS LLREWYLQDP YPNPSKKREL AQATGLTPTQ VGNWFKNRRQ RDRAAAAKNR LQHQAIGPSG MRSLAEPGCP THGSAESPST AASPTTSVSS LTERADTGTS ILSVTSSDSE CDV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.