Genular: Defining Cellular Identity and Function

Details for: Six3

Gene ID: 20473

Symbol: Six3

Ensembl ID: ENSMUSG00000038805

Description: sine oculis-related homeobox 3

Associated with

Apoptotic process involved in development
(GO:1902742)
Brain development
(GO:0007420)
Camera-type eye development
(GO:0043010)
Cell proliferation in forebrain
(GO:0021846)
Circadian behavior
(GO:0048512)
Diencephalon development
(GO:0021536)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Epithelial cell maturation
(GO:0002070)
Eye development
(GO:0001654)
Forebrain anterior/posterior pattern specification
(GO:0021797)
Forebrain dorsal/ventral pattern formation
(GO:0021798)
Gonad development
(GO:0008406)
Histone deacetylase binding
(GO:0042826)
Lens development in camera-type eye
(GO:0002088)
Lens fiber cell apoptotic process
(GO:1990086)
Lens fiber cell differentiation
(GO:0070306)
Lens induction in camera-type eye
(GO:0060235)
Multicellular organism development
(GO:0007275)
Multicellular organism growth
(GO:0035264)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of wnt signaling pathway
(GO:0030178)
Neuroblast differentiation
(GO:0014016)
Neuroblast migration
(GO:0097402)
Nucleus
(GO:0005634)
Optic vesicle morphogenesis
(GO:0003404)
Pituitary gland development
(GO:0021983)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Proximal/distal axis specification
(GO:0009946)
Regulation of cell cycle phase transition
(GO:1901987)
Regulation of cell population proliferation
(GO:0042127)
Regulation of neural precursor cell proliferation
(GO:2000177)
Regulation of neural retina development
(GO:0061074)
Regulation of neuroblast proliferation
(GO:1902692)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signaling receptor binding
(GO:0005102)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Thyroid gland development
(GO:0030878)
Transcription corepressor binding
(GO:0001222)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Homeobox protein SIX3

Genular Protein ID: 2479544318

Symbol: SIX3_MOUSE

Name: Homeobox protein SIX3

UniProtKB Accession Codes:

Q62233 P70176 P70177 Q4QQQ3

Database IDs:

Citations:

PubMed ID: 8575305

Title: Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.

PubMed ID: 8575305

DOI: 10.1242/dev.121.12.4045

PubMed ID: 8814301

Title: Identification and expression of Six family genes in mouse retina.

PubMed ID: 8814301

DOI: 10.1016/0014-5793(96)00899-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11458394

Title: Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.

PubMed ID: 11458394

DOI: 10.1002/dvdy.1148

PubMed ID: 11139622

Title: Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.

PubMed ID: 11139622

DOI: 10.1093/nar/29.2.515

PubMed ID: 12050133

Title: Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.

PubMed ID: 12050133

DOI: 10.1242/dev.129.12.2835

PubMed ID: 12163408

Title: Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.

PubMed ID: 12163408

DOI: 10.1242/dev.129.17.4057

PubMed ID: 12072567

Title: Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype.

PubMed ID: 12072567

DOI: 10.1073/pnas.132195699

PubMed ID: 12569128

Title: Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.

PubMed ID: 12569128

DOI: 10.1101/gad.1059403

PubMed ID: 16024294

Title: Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction.

PubMed ID: 16024294

DOI: 10.1016/j.modgep.2005.04.010

PubMed ID: 17066077

Title: Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.

PubMed ID: 17066077

DOI: 10.1038/sj.emboj.7601398

PubMed ID: 17666527

Title: Repression of Six3 by a corepressor regulates rhodopsin expression.

PubMed ID: 17666527

DOI: 10.1073/pnas.0705878104

PubMed ID: 17576749

Title: Six3 controls the neural progenitor status in the murine CNS.

PubMed ID: 17576749

DOI: 10.1093/cercor/bhm092

PubMed ID: 18094027

Title: Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.

PubMed ID: 18094027

DOI: 10.1242/dev.010082

PubMed ID: 18775421

Title: Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.

PubMed ID: 18775421

DOI: 10.1016/j.ydbio.2008.08.008

PubMed ID: 18694563

Title: Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.

PubMed ID: 18694563

DOI: 10.1016/j.devcel.2008.07.003

PubMed ID: 19606496

Title: EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally.

PubMed ID: 19606496

DOI: 10.1002/humu.21094

PubMed ID: 20682799

Title: Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor.

PubMed ID: 20682799

DOI: 10.1158/0008-5472.can-10-0909

PubMed ID: 20890044

Title: Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.

PubMed ID: 20890044

DOI: 10.1172/jci43219

PubMed ID: 22071110

Title: Six3 is required for ependymal cell maturation.

PubMed ID: 22071110

DOI: 10.1242/dev.067470

PubMed ID: 23792023

Title: Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.

PubMed ID: 23792023

DOI: 10.1016/j.ydbio.2013.06.016

Sequence Information:

Length: 333
Mass: 35593
Checksum: 1AD7D3C4388043B9
Sequence:

MVFRSPLDLY SSHFLLPNFA DSHHCSLLLA SSGGGSGASG GGGGAGGGGG GNRAGGGGAG 
GAGGGSGGGG SRAPPEELSM FQLPTLNFSP EQVASVCETL EETGDIERLG RFLWSLPVAP 
GACEAINKHE SILRARAVVA FHTGNFRDLY HILENHKFTK ESHGKLQAMW LEAHYQEAEK 
LRGRPLGPVD KYRVRKKFPL PRTIWDGEQK THCFKERTRS LLREWYLQDP YPNPSKKREL 
AQATGLTPTQ VGNWFKNRRQ RDRAAAAKNR LQHQAIGPSG MRSLAEPGCP THGSAESPST 
AASPTTSVSS LTERADTGTS ILSVTSSDSE CDV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Six3

Associated with

Other Information

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. PubMed ID: 8575305

Identification and expression of Six family genes in mouse retina. PubMed ID: 8814301

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. PubMed ID: 11458394

Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. PubMed ID: 11139622

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. PubMed ID: 12050133

Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. PubMed ID: 12163408

Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. PubMed ID: 12072567

Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. PubMed ID: 12569128

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. PubMed ID: 16024294

Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. PubMed ID: 17066077

Repression of Six3 by a corepressor regulates rhodopsin expression. PubMed ID: 17666527

Six3 controls the neural progenitor status in the murine CNS. PubMed ID: 17576749

Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. PubMed ID: 18094027

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. PubMed ID: 18775421

Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. PubMed ID: 18694563

EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. PubMed ID: 19606496

Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor. PubMed ID: 20682799

Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. PubMed ID: 20890044

Six3 is required for ependymal cell maturation. PubMed ID: 22071110

Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain. PubMed ID: 23792023