Details for: Six4

Gene ID: 20474

Symbol: Six4

Ensembl ID: ENSMUSG00000034460

Description: sine oculis-related homeobox 4

Associated with

  • Anatomical structure development
    (GO:0048856)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Fungiform papilla morphogenesis
    (GO:0061197)
  • Generation of neurons
    (GO:0048699)
  • Inner ear morphogenesis
    (GO:0042472)
  • Male gonad development
    (GO:0008584)
  • Male sex determination
    (GO:0030238)
  • Male sex differentiation
    (GO:0046661)
  • Metanephric mesenchyme development
    (GO:0072075)
  • Multicellular organism development
    (GO:0007275)
  • Myoblast migration
    (GO:0051451)
  • Myotome development
    (GO:0061055)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of satellite cell differentiation
    (GO:1902725)
  • Nucleus
    (GO:0005634)
  • Olfactory placode formation
    (GO:0030910)
  • Pharyngeal system development
    (GO:0060037)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of ureteric bud formation
    (GO:0072107)
  • Protein binding
    (GO:0005515)
  • Protein localization to nucleus
    (GO:0034504)
  • Regulation of branch elongation involved in ureteric bud branching
    (GO:0072095)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of synaptic assembly at neuromuscular junction
    (GO:0008582)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sarcomere organization
    (GO:0045214)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle fiber differentiation
    (GO:0098528)
  • Skeletal muscle tissue development
    (GO:0007519)
  • Thymus development
    (GO:0048538)
  • Tongue development
    (GO:0043586)
  • Transcription regulator complex
    (GO:0005667)
  • Trigeminal ganglion development
    (GO:0061551)

Other Information

Genular Protein ID: 1117764943

Symbol: SIX4_MOUSE

Name: Homeobox protein SIX4

UniProtKB Accession Codes:

Q61321 B2RQH3 Q61322 Q61323

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 45 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8628654

Title: Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development.

PubMed ID: 8628654

DOI: 10.1093/nar/24.2.303

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9990334

Title: Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development.

PubMed ID: 9990334

DOI: 10.1006/exer.1998.0562

PubMed ID: 10490620

Title: Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.

PubMed ID: 10490620

DOI: 10.1128/mcb.19.10.6815

PubMed ID: 11313460

Title: Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development.

PubMed ID: 11313460

DOI: 10.1128/mcb.21.10.3343-3350.2001

PubMed ID: 12215533

Title: Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.

PubMed ID: 12215533

DOI: 10.1128/mcb.22.19.6759-6766.2002

PubMed ID: 14966291

Title: Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.

PubMed ID: 14966291

DOI: 10.1128/mcb.24.5.2132-2143.2004

PubMed ID: 15788460

Title: Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo.

PubMed ID: 15788460

DOI: 10.1242/dev.01773

PubMed ID: 15955062

Title: Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.

PubMed ID: 15955062

DOI: 10.1111/j.1742-4658.2005.04716.x

PubMed ID: 16938278

Title: Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis.

PubMed ID: 16938278

DOI: 10.1016/j.brainres.2006.07.103

PubMed ID: 16530750

Title: Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.

PubMed ID: 16530750

DOI: 10.1016/j.ydbio.2005.12.015

PubMed ID: 17300925

Title: Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.

PubMed ID: 17300925

DOI: 10.1016/j.mod.2007.01.002

PubMed ID: 17592144

Title: Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs.

PubMed ID: 17592144

DOI: 10.1073/pnas.0611299104

PubMed ID: 19027001

Title: Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4.

PubMed ID: 19027001

DOI: 10.1016/j.ydbio.2008.10.039

PubMed ID: 19962975

Title: Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome.

PubMed ID: 19962975

DOI: 10.1016/j.ydbio.2009.11.031

PubMed ID: 20515681

Title: Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.

PubMed ID: 20515681

DOI: 10.1016/j.ydbio.2010.05.509

PubMed ID: 20696153

Title: Six family genes control the proliferation and differentiation of muscle satellite cells.

PubMed ID: 20696153

DOI: 10.1016/j.yexcr.2010.08.001

PubMed ID: 21884692

Title: Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.

PubMed ID: 21884692

DOI: 10.1016/j.ydbio.2011.08.010

PubMed ID: 21978088

Title: Development of gustatory papillae in the absence of Six1 and Six4.

PubMed ID: 21978088

DOI: 10.1111/j.1469-7580.2011.01435.x

PubMed ID: 23987514

Title: Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development.

PubMed ID: 23987514

DOI: 10.1016/j.devcel.2013.06.018

Sequence Information:

  • Length: 775
  • Mass: 82263
  • Checksum: B06EBB64E04E5061
  • Sequence:
    • MSSSSPTGQI ASAADIKQEN GMESASEGQE AHREVAGGAA AGLSPPAPAP FPLEPGDAAA 
ASRVSREEGA AAAGAADQVQ LHSELLGRHQ HAAAAQPPLA FSPDHVACVC EALQQGGNLD 
RLARFLWSLP QSDLLRGNES LLKARALVAF HQGIYPELYS ILESHSFESA NHPLLQQLWY 
KARYTEAERA RGRPLGAVDK YRLRRKFPLP RTIWDGEETV YCFKEKSRNA LKELYKQNRY 
PSPAEKRHLA KITGLSLTQV SNWFKNRRQR DRNPSETQSK SESDGNPSTE DESSKGHEDL 
SPHPLSGASD GVTNLSLSSH VEPVYMQQIG NAKISLSSSG VLLNGSLVPA STSPVFLNGN 
SFIQGHNGVI LNGLNVGNTQ TVSLNPPKMS SNIVGNGIAM TDILGSTSQD VKEFKVLQSS 
AVNSAATTSY SPSAPVSFPG LIPCTEVKRE GIQTVASQDG GSVVTFTTPV QINQYGIVQI 
PNSGANGQFL NGSIGFSPLQ LPPVSVAASQ GNLSVTPSTS DGSTFTSEPA TVQHGKLFLS 
PLTPSAVVYT VPNSGQTVGA VKQEGLERGL VFSQLMPVNH SAQVNASLSS ENLSGSGLHP 
LTSSLVNVSA AHGFSLTPPT LLNPTELNPD LAESQPVSAP VASKCTVSSV SNTNYATLQN 
CSLIPGQDLL SGPMTQAALG EIVPTAEEQV SHASTAVHQD FVREQRLVLQ SVPNIKENFL 
QNSENKATNN LMMLDSKSKY VLDGMVEAGC EDLGTDKKEL AKLQTVQLDE DMQDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.