Details for: Six5

Gene ID: 20475

Symbol: Six5

Ensembl ID: ENSMUSG00000040841

Description: sine oculis-related homeobox 5

Associated with

  • Cell population proliferation
    (GO:0008283)
  • Cytosol
    (GO:0005829)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Golgi apparatus
    (GO:0005794)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Lens development in camera-type eye
    (GO:0002088)
  • Leydig cell proliferation
    (GO:0160024)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of skeletal muscle satellite cell proliferation
    (GO:1902723)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Spermatid development
    (GO:0007286)
  • Transcription regulator complex
    (GO:0005667)

Other Information

Genular Protein ID: 785547005

Symbol: SIX5_MOUSE

Name: Homeobox protein SIX5

UniProtKB Accession Codes:

P70178

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 1 GO 20 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8814301

Title: Identification and expression of Six family genes in mouse retina.

PubMed ID: 8814301

DOI: 10.1016/0014-5793(96)00899-x

PubMed ID: 10490620

Title: Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.

PubMed ID: 10490620

DOI: 10.1128/mcb.19.10.6815

PubMed ID: 11978764

Title: Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.

PubMed ID: 11978764

DOI: 10.1093/hmg/11.9.1045

PubMed ID: 12215533

Title: Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.

PubMed ID: 12215533

DOI: 10.1128/mcb.22.19.6759-6766.2002

Sequence Information:

  • Length: 719
  • Mass: 73717
  • Checksum: B559618D3C831CD6
  • Sequence:
    • MATSPAEPSA GPAARGEAAA ATEEQEEEAR QLLQTLQAAE GEAAAAGAGD AAAAADSGSP 
SGPGSPRETV TEVPTGLRFS PEQVACVCEA LLQAGHAGRL SRFLGALPPA ERLRGSDPVL 
RARALVAFQR GEYAELYQLL ESRPFPAAHH AFLQDLYLRA RYHEAERARG RALGAVDKYR 
LRKKFPLPKT IWDGEETVYC FKERSRAALK ACYRGNRYPT PDEKRRLATL TGLSLTQVSN 
WFKNRRQRDR TGTGGGAPCK SESDGNPTTE DESSRSPEDL ERGVASMAAE APAQSSIFLA 
GATSPATCPA SSSILVNGSF LAASSPPAVL LNGSPVIINS LALGENSSLG PLLLTGGSAP 
QPQPSLQGVS EAKNSLVLDP QTGEVRLDEA QSEAPETKGV HGTTGEEIPG ALPQVVPGPP 
PASTFPLTPG AVPAVAAPQV VPLSPSSGYP TGLSPTSPRL NLPQVVPTSQ VVTLPQAVGP 
LQLLAAGPGS PVKVAAAAGP TNVHLINSSV GVTALQLPSS TAPGNFLLAN PVSGSPIVTG 
VAVQQGKIIL TATFPTSMLV SQVLPPAPSL ALPLKQEPAI TVPEGALPVG PSPTLPEGHT 
LGPISTQPLP PASVVTSGTS LPFSPDSSGL LSSFSAPLPE GLMLSPAAVP VWPAGLELST 
GVEGLGTQAT HTVLRLPDPD PQGLLLGATT GTEVDEGLEA EAKVLTQLQS VPVEEPLEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.