Genular: Defining Cellular Identity and Function

Details for: Vps4b

Gene ID: 20479

Symbol: Vps4b

Ensembl ID: ENSMUSG00000009907

Description: vacuolar protein sorting 4B

Associated with

Endosomal sorting complex required for transport (escrt)
(R-MMU-917729)
Membrane trafficking
(R-MMU-199991)
Vesicle-mediated transport
(R-MMU-5653656)
Angiogenesis
(GO:0001525)
Atpase complex
(GO:1904949)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Autophagosome maturation
(GO:0097352)
Autophagy
(GO:0006914)
Canonical wnt signaling pathway
(GO:0060070)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Central nervous system development
(GO:0007417)
Centrosome
(GO:0005813)
Cholesterol transport
(GO:0030301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome organization
(GO:0007032)
Endosome to lysosome transport via multivesicular body sorting pathway
(GO:0032510)
Escrt iii complex disassembly
(GO:1904903)
Establishment of blood-brain barrier
(GO:0060856)
Flemming body
(GO:0090543)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Late endosomal microautophagy
(GO:0061738)
Late endosome to lysosome transport via multivesicular body sorting pathway
(GO:0061764)
Membrane
(GO:0016020)
Membrane fission
(GO:0090148)
Midbody
(GO:0030496)
Midbody abscission
(GO:0061952)
Mitotic metaphase chromosome alignment
(GO:0007080)
Multivesicular body assembly
(GO:0036258)
Multivesicular body sorting pathway
(GO:0071985)
Negative regulation of exosomal secretion
(GO:1903542)
Nuclear membrane reassembly
(GO:0031468)
Nuclear pore
(GO:0005643)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Nucleus organization
(GO:0006997)
Plasma membrane
(GO:0005886)
Plasma membrane repair
(GO:0001778)
Positive regulation of centriole elongation
(GO:1903724)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Potassium ion transport
(GO:0006813)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein depolymerization
(GO:0051261)
Protein homodimerization activity
(GO:0042803)
Protein transport
(GO:0015031)
Regulation of centrosome duplication
(GO:0010824)
Regulation of mitotic spindle assembly
(GO:1901673)
Response to lipid
(GO:0033993)
Spindle pole
(GO:0000922)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
(GO:0043162)
Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
(GO:0090611)
Vacuolar transport
(GO:0007034)
Vacuole organization
(GO:0007033)
Viral budding from plasma membrane
(GO:0046761)
Viral budding via host escrt complex
(GO:0039702)

Other Information

Proteins

Suppressor of K(+) transport growth defect 1
Q8BM73_MOUSE

Genular Protein ID: 3147821527

Symbol: VPS4B_MOUSE

Name: Suppressor of K(+) transport growth defect 1

UniProtKB Accession Codes:

P46467 Q91W22 Q9R1C9

Database IDs:

Citations:

PubMed ID: 8082782

Title: Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast.

PubMed ID: 8082782

DOI: 10.1016/0014-5793(94)00879-5

PubMed ID: 10393249

Title: Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking.

PubMed ID: 10393249

DOI: 10.1016/s0378-1119(99)00163-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12594041

Title: Comparative sequence and expression analyses of four mammalian VPS4 genes.

PubMed ID: 12594041

DOI: 10.1016/s0378-1119(02)01205-2

PubMed ID: 10637304

Title: ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking.

PubMed ID: 10637304

DOI: 10.1091/mbc.11.1.227

PubMed ID: 10679028

Title: The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells.

PubMed ID: 10679028

DOI: 10.1091/mbc.11.2.747

PubMed ID: 15173323

Title: Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B.

PubMed ID: 15173323

DOI: 10.1242/jcs.01170

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 18796009

Title: Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B.

PubMed ID: 18796009

DOI: 10.1111/j.1600-0854.2008.00831.x

Sequence Information:

Length: 444
Mass: 49419
Checksum: AA95B607DF8706A1
Sequence:

MASTNTNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ GDKAKQSIRA 
KCTEYLDRAE KLKEYLKKKE KKPQKPVKEE QSGPVDEKGN DSDGEAESDD PEKKKLQNQL 
QGAIVIERPN VKWSDVAGLE GAKEALKEAV ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK 
SYLAKAVATE ANNSTFFSIS SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC 
GSRSENESEA ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL 
PEAHARAAMF RLHLGSTQNS LTEADFQELG RKTDGYSGAD ISIIVRDALM QPVRKVQSAT 
HFKKVRGPSR ADPNCIVNDL LTPCSPGDPG AIEMTWMDVP GDKLLEPVVS MWDMLRSLSS 
TKPTVNEQDL LKLKKFTEDF GQEG

Genular Protein ID: 2534143570

Symbol: Q8BM73_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BM73

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 89
Mass: 9846
Checksum: 6410862DE3AAB761
Sequence:

VQSATHFKKV RGPSRADPNC IVNDLLTPCS PGDPGAIEMT WMDVPGDKLL EPVVSMWDML 
RSLSSTKPTV NEQDLLKLKK FTEDFGQEG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vps4b

Associated with

Other Information

Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast. PubMed ID: 8082782

Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. PubMed ID: 10393249

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative sequence and expression analyses of four mammalian VPS4 genes. PubMed ID: 12594041

ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. PubMed ID: 10637304

The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells. PubMed ID: 10679028

Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. PubMed ID: 15173323

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B. PubMed ID: 18796009

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073