Details for: AK4

Gene ID: 205

Symbol: AK4

Ensembl ID: ENSG00000162433

Description: adenylate kinase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.23
    Marker Score: 2045
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.19
    Marker Score: 7788
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.09
    Marker Score: 6838
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.8
    Marker Score: 1053
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.67
    Marker Score: 3941
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.66
    Marker Score: 3366
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.62
    Marker Score: 3567
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.61
    Marker Score: 34319
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.59
    Marker Score: 1922
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.52
    Marker Score: 1910
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.48
    Marker Score: 14095
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.45
    Marker Score: 1369.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.45
    Marker Score: 842
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2796
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.33
    Marker Score: 2360
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2477.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.29
    Marker Score: 542
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19681
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 76540
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.23
    Marker Score: 5322
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10323
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.19
    Marker Score: 2915
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.19
    Marker Score: 676
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1672
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.13
    Marker Score: 1371
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.13
    Marker Score: 7274
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.13
    Marker Score: 279
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3025
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.05
    Marker Score: 585
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.04
    Marker Score: 10457
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251767
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.03
    Marker Score: 601
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2346
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.03
    Marker Score: 23004
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.02
    Marker Score: 9569
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.01
    Marker Score: 5456
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1
    Marker Score: 8630
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1
    Marker Score: 366
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48010
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.98
    Marker Score: 10169
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.97
    Marker Score: 2203
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.95
    Marker Score: 275
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.95
    Marker Score: 12743
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.95
    Marker Score: 7386
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.95
    Marker Score: 6033
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.93
    Marker Score: 3455
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.91
    Marker Score: 477
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.91
    Marker Score: 528
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.9
    Marker Score: 264
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.9
    Marker Score: 2815
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5380
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.84
    Marker Score: 354
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 495
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.82
    Marker Score: 12207
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.77
    Marker Score: 1270
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.77
    Marker Score: 2986
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1187
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.76
    Marker Score: 188
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.75
    Marker Score: 503
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.75
    Marker Score: 3670.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.74
    Marker Score: 739
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.73
    Marker Score: 5580
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 496
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 344
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3006
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1051
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.7
    Marker Score: 1671.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7
    Marker Score: 458
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.69
    Marker Score: 574
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.69
    Marker Score: 2643
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.68
    Marker Score: 186
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.67
    Marker Score: 228
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 558
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.64
    Marker Score: 312
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 204
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.63
    Marker Score: 398
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.62
    Marker Score: 164
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.62
    Marker Score: 1519
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.61
    Marker Score: 403
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6
    Marker Score: 806
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6
    Marker Score: 632
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6
    Marker Score: 247
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.59
    Marker Score: 224

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Other Information

**Key characteristics:** * AK4 is a member of the adenylate kinase family of enzymes. * It is a highly conserved protein with sequences found in organisms from yeast to humans. * It is involved in a variety of cellular processes, including oxidative phosphorylation, nucleotide metabolism, and cell signaling. **Pathways and functions:** * AK4 is involved in the regulation of oxidative phosphorylation by catalyzing the transfer of phosphate from ADP to GTP. * It is also involved in the synthesis of nucleotides and the regulation of cell signaling pathways. * It is a key regulator of cell growth, differentiation, and apoptosis. **Clinical significance:** * Mutations in the AK4 gene have been linked to a number of human diseases, including cancer and cardiovascular disease. * Targeting AK4 has been explored as a therapeutic strategy for these diseases. **Additional notes:** * AK4 is a highly regulated protein. Its expression is controlled by a variety of factors, including growth factors, cytokines, and nutrients. * It is a key regulator of cellular metabolism and growth. * It is a promising target for the treatment of human diseases.

Genular Protein ID: 1967786300

Symbol: KAD4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P27144 B2R927 D3DQ62 Q6IBH4 Q6NXQ5 Q8IUU9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 2 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 15 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 3 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639383

Title: Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene.

PubMed ID: 1639383

DOI: 10.1016/0888-7543(92)90122-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11485571

Title: Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix.

PubMed ID: 11485571

DOI: 10.1042/0264-6021:3580225

PubMed ID: 19130895

Title: Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase.

PubMed ID: 19130895

DOI: 10.1016/j.biocel.2008.12.002

PubMed ID: 19766732

Title: Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4.

PubMed ID: 19766732

DOI: 10.1016/j.biocel.2009.09.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23474458

Title: Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells.

PubMed ID: 23474458

DOI: 10.1016/j.abb.2013.02.014

PubMed ID: 23416111

Title: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.

PubMed ID: 23416111

DOI: 10.1016/j.biocel.2013.02.004

PubMed ID: 24767988

Title: A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.

PubMed ID: 24767988

DOI: 10.1016/j.celrep.2014.03.065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26980435

Title: Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4.

PubMed ID: 26980435

DOI: 10.1186/s13046-016-0322-2

PubMed ID: 19073142

Title: Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.

PubMed ID: 19073142

DOI: 10.1016/j.bbrc.2008.12.012

Sequence Information:

  • Length: 223
  • Mass: 25268
  • Checksum: 653341A8EB3BC723
  • Sequence:
    • MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK 
SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK 
DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP 
VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY

Genular Protein ID: 80100134

Symbol: F8VS11_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VS11

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 EMBL 5 EPD 1 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HAMAP 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 3 Proteomes 3 RefSeq 2 RuleBase 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 171
  • Mass: 19781
  • Checksum: 88D269262743092C
  • Sequence:
    • MAKQYIEKSL LVPDHVITRL MMSELENRRG QHWLLDGFPR TLGQAEALDK ICEVDLVISL 
NIPFETLKDR LSRRWIHPPS GRVYNLDFNP PHVHGIDDVT GEPLVQQEDD KPEAVAARLR 
QYKDVAKPVI ELYKSRGVLH QFSGTETNKI WPYVYTLFSN KITPIQSKEA Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.