Details for: AK4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 179.1119
Cell Significance Index: -27.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 107.1978
Cell Significance Index: -27.1900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 66.7561
Cell Significance Index: -27.5000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 22.6772
Cell Significance Index: -27.9600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.7322
Cell Significance Index: -28.7500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.1033
Cell Significance Index: -28.0300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.8342
Cell Significance Index: -10.5800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.9292
Cell Significance Index: 557.4500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7077
Cell Significance Index: 338.9100 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.6736
Cell Significance Index: 12.9000 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.2052
Cell Significance Index: 20.2700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1019
Cell Significance Index: 179.2100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.1003
Cell Significance Index: 18.5400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0306
Cell Significance Index: 61.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8074
Cell Significance Index: 61.9600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7953
Cell Significance Index: 17.2300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5788
Cell Significance Index: 40.0300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5701
Cell Significance Index: 26.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5595
Cell Significance Index: 25.3600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5330
Cell Significance Index: 106.9200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5317
Cell Significance Index: 24.7900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4873
Cell Significance Index: 48.2000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4418
Cell Significance Index: 54.3200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.4406
Cell Significance Index: 31.1600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4273
Cell Significance Index: 77.0300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4093
Cell Significance Index: 52.8800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3741
Cell Significance Index: 19.6400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3683
Cell Significance Index: 132.1000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3675
Cell Significance Index: 24.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3649
Cell Significance Index: 9.6000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3277
Cell Significance Index: 144.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2654
Cell Significance Index: 144.9400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2544
Cell Significance Index: 7.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2268
Cell Significance Index: 156.8300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2210
Cell Significance Index: 9.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2064
Cell Significance Index: 15.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2062
Cell Significance Index: 10.7100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1928
Cell Significance Index: 7.3000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1763
Cell Significance Index: 4.8000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1565
Cell Significance Index: 2.3100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1217
Cell Significance Index: 165.5000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1036
Cell Significance Index: 47.0400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0894
Cell Significance Index: 2.2400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0835
Cell Significance Index: 128.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0722
Cell Significance Index: 45.8600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0607
Cell Significance Index: 1.0400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0515
Cell Significance Index: 1.4700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0333
Cell Significance Index: 0.9600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0283
Cell Significance Index: 53.3300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0251
Cell Significance Index: 46.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0046
Cell Significance Index: -0.1600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0073
Cell Significance Index: -4.5700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0126
Cell Significance Index: -9.2600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0140
Cell Significance Index: -10.3400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0155
Cell Significance Index: -1.9900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0324
Cell Significance Index: -0.6900 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0340
Cell Significance Index: -0.2600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0368
Cell Significance Index: -20.7600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0379
Cell Significance Index: -28.6600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0438
Cell Significance Index: -4.4700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0653
Cell Significance Index: -1.4000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0766
Cell Significance Index: -11.1300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0777
Cell Significance Index: -22.3700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0802
Cell Significance Index: -6.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0820
Cell Significance Index: -14.0000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0888
Cell Significance Index: -1.3100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0954
Cell Significance Index: -20.1000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0988
Cell Significance Index: -13.5700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1128
Cell Significance Index: -13.1500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1472
Cell Significance Index: -16.8100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1719
Cell Significance Index: -3.5700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1901
Cell Significance Index: -3.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2070
Cell Significance Index: -23.7100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2134
Cell Significance Index: -22.2200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2278
Cell Significance Index: -26.8600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2584
Cell Significance Index: -5.9700 - Cell Name: germ cell (CL0000586)
Fold Change: -0.2854
Cell Significance Index: -2.1600 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.2894
Cell Significance Index: -1.2600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3024
Cell Significance Index: -18.5900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3086
Cell Significance Index: -8.2400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3276
Cell Significance Index: -20.6500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3551
Cell Significance Index: -21.7700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3610
Cell Significance Index: -20.2600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.3777
Cell Significance Index: -4.6900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4067
Cell Significance Index: -4.2100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4359
Cell Significance Index: -28.1300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4371
Cell Significance Index: -5.4500 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.4407
Cell Significance Index: -7.6200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4427
Cell Significance Index: -14.1000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4556
Cell Significance Index: -13.0600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4823
Cell Significance Index: -14.1700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5043
Cell Significance Index: -13.4900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.5178
Cell Significance Index: -7.2400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5502
Cell Significance Index: -13.7200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5641
Cell Significance Index: -18.4700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.5911
Cell Significance Index: -7.4600 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: -0.5960
Cell Significance Index: -5.2500 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.6012
Cell Significance Index: -5.1100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6012
Cell Significance Index: -19.2600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6029
Cell Significance Index: -20.9500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1967786300
Symbol: KAD4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1639383
Title: Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene.
PubMed ID: 1639383
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11485571
Title: Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix.
PubMed ID: 11485571
PubMed ID: 19130895
Title: Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase.
PubMed ID: 19130895
PubMed ID: 19766732
Title: Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4.
PubMed ID: 19766732
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23474458
Title: Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells.
PubMed ID: 23474458
PubMed ID: 23416111
Title: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.
PubMed ID: 23416111
PubMed ID: 24767988
Title: A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.
PubMed ID: 24767988
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 26980435
Title: Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4.
PubMed ID: 26980435
PubMed ID: 19073142
Title: Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.
PubMed ID: 19073142
Sequence Information:
- Length: 223
- Mass: 25268
- Checksum: 653341A8EB3BC723
- Sequence:
MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY
Genular Protein ID: 80100134
Symbol: F8VS11_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 171
- Mass: 19781
- Checksum: 88D269262743092C
- Sequence:
MAKQYIEKSL LVPDHVITRL MMSELENRRG QHWLLDGFPR TLGQAEALDK ICEVDLVISL NIPFETLKDR LSRRWIHPPS GRVYNLDFNP PHVHGIDDVT GEPLVQQEDD KPEAVAARLR QYKDVAKPVI ELYKSRGVLH QFSGTETNKI WPYVYTLFSN KITPIQSKEA Y
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.