Details for: AK4

Gene ID: 205

Symbol: AK4

Ensembl ID: ENSG00000162433

Description: adenylate kinase 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.23
    Marker Score: 2,045
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.19
    Marker Score: 7,788
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.09
    Marker Score: 6,838
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.8
    Marker Score: 1,053
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.67
    Marker Score: 3,941
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.66
    Marker Score: 3,366
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.62
    Marker Score: 3,567
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.61
    Marker Score: 34,319
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.59
    Marker Score: 1,922
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.52
    Marker Score: 1,910
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.48
    Marker Score: 14,095
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,704
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.45
    Marker Score: 1,370
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.45
    Marker Score: 842
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2,796
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.33
    Marker Score: 2,360
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2,478
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.29
    Marker Score: 542
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19,681
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 76,540
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.23
    Marker Score: 5,322
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10,323
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.19
    Marker Score: 2,915
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.19
    Marker Score: 676
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1,672
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.13
    Marker Score: 1,371
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.13
    Marker Score: 7,274
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.13
    Marker Score: 279
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3,025
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.05
    Marker Score: 585
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.04
    Marker Score: 10,457
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,767
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.03
    Marker Score: 601
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2,346
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.03
    Marker Score: 23,004
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.02
    Marker Score: 9,569
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.01
    Marker Score: 5,456
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1
    Marker Score: 8,630
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1
    Marker Score: 366
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,010
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.98
    Marker Score: 10,169
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.97
    Marker Score: 2,203
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.95
    Marker Score: 275
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.95
    Marker Score: 12,743
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.95
    Marker Score: 7,386
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.95
    Marker Score: 6,033
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.93
    Marker Score: 3,455
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,318
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.91
    Marker Score: 477
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.91
    Marker Score: 528
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.9
    Marker Score: 264
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.9
    Marker Score: 2,815
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5,380
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.84
    Marker Score: 354
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 495
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.82
    Marker Score: 12,207
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.77
    Marker Score: 1,270
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.77
    Marker Score: 2,986
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.77
    Marker Score: 1,187
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.76
    Marker Score: 188
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.75
    Marker Score: 503
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.75
    Marker Score: 3,671
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.74
    Marker Score: 739
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.73
    Marker Score: 5,580
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 496
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 344
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3,006
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.71
    Marker Score: 1,051
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.7
    Marker Score: 1,672
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7
    Marker Score: 458
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.69
    Marker Score: 574
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.69
    Marker Score: 2,643
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.68
    Marker Score: 186
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.67
    Marker Score: 228
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 558
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.64
    Marker Score: 312
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 204
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.63
    Marker Score: 398
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.62
    Marker Score: 164
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.62
    Marker Score: 1,519
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.61
    Marker Score: 403
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.6
    Marker Score: 806
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6
    Marker Score: 632
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.6
    Marker Score: 247
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.59
    Marker Score: 224

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AK4 is a member of the adenylate kinase family, which is responsible for maintaining the balance of adenylate and ATP levels within cells. This enzyme is characterized by its ability to catalyze the interconversion of adenylate and ATP, as well as its involvement in various cellular processes, including energy metabolism, nucleotide biosynthesis, and response to hypoxia. AK4 exhibits high specificity for its substrates, adenylate and ATP, and its activity is crucial for maintaining the energy homeostasis of cells. **Pathways and Functions:** AK4 is involved in several key pathways, including: 1. **Adenylate Kinase Activity**: AK4 catalyzes the interconversion of adenylate and ATP, playing a critical role in maintaining energy homeostasis. 2. **Adp Biosynthetic Process**: AK4 is involved in the biosynthesis of adenosine diphosphate (ADP) from ATP, which is essential for energy metabolism. 3. **Amp Metabolic Process**: AK4 regulates the metabolic process of AMP (adenosine monophosphate) to ATP, maintaining the balance of adenylate and ATP levels. 4. **Cellular Response to Hypoxia**: AK4 is involved in the cellular response to hypoxia, helping to maintain energy homeostasis under low oxygen conditions. 5. **Nucleoside Biosynthesis**: AK4 plays a role in the biosynthesis of nucleosides, including adenine, guanine, and cytosine, which are essential for nucleic acid synthesis. **Clinical Significance:** AK4 has significant clinical implications, particularly in the context of: 1. **Neurological Disorders**: AK4's involvement in neuronal energy metabolism makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: AK4's role in nucleotide biosynthesis and energy metabolism makes it a potential target for cancer therapy. 3. **Cardiovascular Diseases**: AK4's involvement in energy metabolism and response to hypoxia makes it a potential target for the treatment of cardiovascular diseases, such as heart failure. 4. **Hypoxia-Inducible Factor 1 (HIF-1)**: AK4's role in cellular response to hypoxia makes it a potential target for the treatment of HIF-1-related diseases, such as anemia and cancer. In conclusion, the AK4 gene plays a crucial role in maintaining energy homeostasis, nucleotide biosynthesis, and cellular response to hypoxia. Its significance in various cellular processes and diseases makes it an attractive target for therapeutic intervention. Further research is necessary to elucidate the mechanisms of AK4 and its potential applications in clinical settings.

Genular Protein ID: 1967786300

Symbol: KAD4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P27144 B2R927 D3DQ62 Q6IBH4 Q6NXQ5 Q8IUU9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 2 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 3 EMBL 15 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 3 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639383

Title: Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene.

PubMed ID: 1639383

DOI: 10.1016/0888-7543(92)90122-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11485571

Title: Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix.

PubMed ID: 11485571

DOI: 10.1042/0264-6021:3580225

PubMed ID: 19130895

Title: Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase.

PubMed ID: 19130895

DOI: 10.1016/j.biocel.2008.12.002

PubMed ID: 19766732

Title: Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4.

PubMed ID: 19766732

DOI: 10.1016/j.biocel.2009.09.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23474458

Title: Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells.

PubMed ID: 23474458

DOI: 10.1016/j.abb.2013.02.014

PubMed ID: 23416111

Title: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.

PubMed ID: 23416111

DOI: 10.1016/j.biocel.2013.02.004

PubMed ID: 24767988

Title: A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.

PubMed ID: 24767988

DOI: 10.1016/j.celrep.2014.03.065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26980435

Title: Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4.

PubMed ID: 26980435

DOI: 10.1186/s13046-016-0322-2

PubMed ID: 19073142

Title: Crystal structure of human adenylate kinase 4 (L171P) suggests the role of hinge region in protein domain motion.

PubMed ID: 19073142

DOI: 10.1016/j.bbrc.2008.12.012

Sequence Information:

  • Length: 223
  • Mass: 25268
  • Checksum: 653341A8EB3BC723
  • Sequence:
    • MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK 
SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK 
DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP 
VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY

Genular Protein ID: 80100134

Symbol: F8VS11_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VS11

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 DNASU 1 EMBL 5 EPD 1 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HAMAP 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 3 Proteomes 3 RefSeq 2 RuleBase 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 171
  • Mass: 19781
  • Checksum: 88D269262743092C
  • Sequence:
    • MAKQYIEKSL LVPDHVITRL MMSELENRRG QHWLLDGFPR TLGQAEALDK ICEVDLVISL 
NIPFETLKDR LSRRWIHPPS GRVYNLDFNP PHVHGIDDVT GEPLVQQEDD KPEAVAARLR 
QYKDVAKPVI ELYKSRGVLH QFSGTETNKI WPYVYTLFSN KITPIQSKEA Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.