Genular: Defining Cellular Identity and Function

Details for: Slc16a1

Gene ID: 20501

Symbol: Slc16a1

Ensembl ID: ENSMUSG00000032902

Description: solute carrier family 16 (monocarboxylic acid transporters), member 1

Associated with

Aspirin adme
(R-MMU-9749641)
Basigin interactions
(R-MMU-210991)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Drug adme
(R-MMU-9748784)
Hemostasis
(R-MMU-109582)
Metabolism
(R-MMU-1430728)
Proton-coupled monocarboxylate transport
(R-MMU-433692)
Pyruvate metabolism
(R-MMU-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
Slc-mediated transmembrane transport
(R-MMU-425407)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Apical plasma membrane
(GO:0016324)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Behavioral response to nutrient
(GO:0051780)
Carboxylic acid transmembrane transport
(GO:1905039)
Carboxylic acid transmembrane transporter activity
(GO:0046943)
Cell junction
(GO:0030054)
Cellular response to organic cyclic compound
(GO:0071407)
Centrosome
(GO:0005813)
Centrosome cycle
(GO:0007098)
Glucose homeostasis
(GO:0042593)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Lactate:proton symporter activity
(GO:0015650)
Lactate transmembrane transport
(GO:0035873)
Lactate transmembrane transporter activity
(GO:0015129)
Lateral plasma membrane
(GO:0016328)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Monocarboxylic acid transmembrane transporter activity
(GO:0008028)
Monocarboxylic acid transport
(GO:0015718)
Organic cyclic compound binding
(GO:0097159)
Plasma membrane
(GO:0005886)
Plasma membrane lactate transport
(GO:0035879)
Protein binding
(GO:0005515)
Pyruvate catabolic process
(GO:0042867)
Pyruvate transmembrane transport
(GO:1901475)
Regulation of insulin secretion
(GO:0050796)
Response to food
(GO:0032094)
Solute:proton symporter activity
(GO:0015295)
Succinate transmembrane transport
(GO:0071422)
Succinate transmembrane transporter activity
(GO:0015141)
Symporter activity
(GO:0015293)
Synapse
(GO:0045202)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)

Other Information

Proteins

Monocarboxylate transporter 1

Genular Protein ID: 2599911537

Symbol: MOT1_MOUSE

Name: Monocarboxylate transporter 1

UniProtKB Accession Codes:

P53986

Database IDs:

Citations:

PubMed ID: 8603082

Title: Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function.

PubMed ID: 8603082

DOI: 10.1016/0005-2736(95)00254-5

PubMed ID: 9725820

Title: Monocarboxylate transporter expression in mouse brain.

PubMed ID: 9725820

DOI: 10.1152/ajpendo.1998.275.3.e516

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22522610

Title: Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic beta-cells leads to relative hyperinsulinism during exercise.

PubMed ID: 22522610

DOI: 10.2337/db11-1531

PubMed ID: 21792931

Title: Basigin interacts with both MCT1 and MCT2 in murine spermatozoa.

PubMed ID: 21792931

DOI: 10.1002/jcp.22949

PubMed ID: 24367518

Title: Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

PubMed ID: 24367518

DOI: 10.1371/journal.pone.0082505

PubMed ID: 32946811

Title: pH-gated succinate secretion regulates muscle remodeling in response to exercise.

PubMed ID: 32946811

DOI: 10.1016/j.cell.2020.08.039

Sequence Information:

Length: 493
Mass: 53267
Checksum: 8B6DAB7741340DD7
Sequence:

MPPAIGGPVG YTPPDGGWGW AVLVGAFISI GFSYAFPKSI TVFFKEIEVI FSATTSEVSW 
ISSIMLAVMY AGGPISSILV NKYGSRPVMI AGGCLSGCGL IAASFCNTVQ ELYLCIGVIG 
GLGLAFNLNP ALTMIGKYFY KKRPLANGLA MAGSPVFLST LAPLNQAFFD IFDWRGSFLI 
LGGLLLNCCV AGSLMRPIGP EQVKLEKLKS KESLQEAGKS DANTDLIGGS PKGEKLSVFQ 
TINKFLDLSL FTHRGFLLYL SGNVVMFFGL FTPLVFLSSY GKSKDFSSEK SAFLLSILAF 
VDMVARPSMG LAANTKWIRP RIQYFFAASV VANGVCHLLA PLSTTYVGFC VYAGVFGFAF 
GWLSSVLFET LMDLIGPQRF SSAVGLVTIV ECCPVLLGPP LLGRLNDMYG DYKYTYWACG 
VILIIAGIYL FIGMGINYRL LAKEQKAEEK QKREGKEDEA STDVDEKPKE TMKAAQSPQQ 
HSSGDPTEEE SPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc16a1

Associated with

Other Information

Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. PubMed ID: 8603082

Monocarboxylate transporter expression in mouse brain. PubMed ID: 9725820

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic beta-cells leads to relative hyperinsulinism during exercise. PubMed ID: 22522610

Basigin interacts with both MCT1 and MCT2 in murine spermatozoa. PubMed ID: 21792931

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice. PubMed ID: 24367518

pH-gated succinate secretion regulates muscle remodeling in response to exercise. PubMed ID: 32946811